-  INCLUSION CRITERIA:

               1. Patients must have histologically documented metastatic solid tumors which have
                  progressed after one line of therapy, or lymphoma which has progressed after
                  initial therapy and without potentially curative options, or patient refuses
                  potentially curative therapy.

               2. Patients must have measurable or evaluable disease

               3. Age greater than or equal to 18 years.

               4. ECOG performance status less than or equal to 2

               5. Life expectancy of greater than 3 months.

               6. Patients must have normal organ and marrow function as defined below:

                  leukocytes greater than or equal to 3,000/mcL

                  absolute neutrophil count greater than or equal to 1,500/mcL

                  platelets greater than or equal to 100,000/mcL

                  total bilirubin within normal institutional limits

                  AST(SGOT)/ALT(SGPT) less than or equal to 2.5 (SqrRoot) institutional upper limit
                  of normal (ULN)

                  Serum creatinine less than or equal to 1.5 (SqrRoot) institutional ULN

                  OR

                  creatinine clearance greater than or equal to 60 mL/min/1.73 m2 for patients with
                  serum creatinine levelsgreater than 1.5 x higher than institutional normal.

               7. Anticoagulation with low-molecular-weight heparin (LMWH) or any direct oral
                  anticoagulant (DOAC, e.g., rivaroxaban, apixaban, dabigatran, or edoxaban) will
                  be permitted. Patients receiving treatment with warfarin will be given the option
                  to switch to LMWH or a

                  DOAC.

               8. Patients must have recovered to grade 1 or baseline from adverse events (AEs)
                  and/or toxicity of prior chemotherapy or biologic therapy. They must not have had
                  chemotherapy, biologic therapy, or definitive radiotherapy within 4 weeks (6
                  weeks for nitrosoureas and mitomycin C) or 5 half-lives, whichever is shorter,
                  prior to entering the study. Palliative-intent radiotherapy (30 Gy or less) must
                  be completed at least 2 weeks prior to start of treatment, and may not be to a
                  lesion that is included as measurable disease. Patients must be greater than or
                  equal to 2 weeks since any investigational agent administered as part of a Phase
                  0 study (where a sub-therapeutic dose of drug is administered) at the PI s
                  discretion, and should have recovered to grade 1 or baseline from any toxicities.

               9. Patients receiving denosumab or bisphosphonates for any cancer or undergoing
                  androgen deprivation therapy for prostate cancer are eligible for this therapy.

              10. Prior therapy with topoisomerase I inhibitors is allowed.

              11. HIV-positive patients are eligible provided the following criteria are met: CD4
                  count >350/mm3, an undetectable viral load, and not receiving prophylaxis
                  antibiotics.

              12. The effects of LMP744 on the developing human fetus are unknown. For this reason,
                  women of child-bearing potential and men must agree to use adequate contraception
                  (hormonal or barrier method of birth control; abstinence) prior to study entry
                  and for the duration of study participation. Should a woman become pregnant or
                  suspect she is pregnant while she or her partner is participating in this study,
                  she should inform her treating physician immediately. Women and men treated or
                  enrolled on this protocol must also agree to use adequate contraception prior to
                  the study, for the duration of study participation, and 4 months after completion
                  of LMP744 administration.

              13. Ability to understand and the willingness to sign a written informed consent
                  document.

              14. Willingness to provide blood and new tumor biopsy samples for research purposes
                  if on the expansion phase of the study.

        EXCLUSION CRITERIA:

          1. Patients who are receiving any other investigational agents.

          2. Patients with clinically significant illnesses which would compromise participation in
             the study, including, but not limited to active or uncontrolled infection, immune
             deficiencies, Hepatitis B, Hepatitis C, uncontrolled diabetes, uncontrolled
             hypertension, symptomatic congestive heart failure, unstable angina pectoris,
             myocardial infarction within the past 6 months, uncontrolled cardiac arrhythmia, or

             psychiatric illness/social situations that would limit compliance with study
             requirements.

          3. Patients with known brain metastases or carcinomatous meningitis are excluded from
             this clinical trial, with the exception of patients whose brain metastatic disease
             status has remained stable for greater than or equal to 1 month after treatment of the
             brain metastases. Patients on anti-seizure medications or steroid therapy may be
             enrolled at the discretion of the Principal Investigator.

          4. Pregnant women are excluded from this study because LMP744 is an agent with the
             potential for teratogenic or abortifacient effects. Because there is an unknown but
             potential risk for adverse events in nursing infants secondary to treatment of the
             mother with LMP744, breastfeeding should be discontinued if the mother is treated.

        INCLUSION OF WOMEN AND MINORITIES:

        Both men and women of all races and ethnic groups are eligible for this trial.