Inclusion Criteria:

        3.1.1 volunteered for the clinical research and signed informed consent. 3.1.2 aged 18-70,
        expected lifetime > 3 months. 3.1.3 gender not limited. 3.1.4 late lung cancer (stage
        IIIb/IV), (IV) with esophageal carcinoma, and melanoma (advanced), no other effective cure
        Treatment method can be selected patients. 3.1.5 biopsy IHC confirmed positive expression,
        NY - ESO - 1 or 50% of the tumor cells IHC staining in 2 + and/or 3 +.Organization based on
        time in the group in the year before, can be a tumor tissue, can also be a pleural effusion
        cells

        Exclusion Criteria:

        3.2.1 this study used in the process of cell preparation ingredients allergy, such as
        penicillin, streptomycin.

        3.2.2 used within a week of tyrosine kinase inhibitors (the treatment such as, for it), or
        other cancer drugs.

        3.2.3 is systemic anti-cancer therapy, including immune therapy, such as accept the immune
        cells within a month back to lose Therapy or biological treatment.6 weeks used cancer
        associated with tumor immune single resistance (including the PD, PD - L1 and - 1 CTLA 4
        single resistance). 3.2.4 have vital organs, such as cardiovascular, respiratory system
        disease, myocardial infarction, myocardial ischemia, the coronary artery bypass History or
        coronary ischemia symptoms, obstructive or restrictive lung disease. 3.2.5 the patient's
        immune tolerance is poor, may on the immune cells in treatment of the reaction of low or
        prone to toxic reactions.

        3.2.6 always have autoimmune and immunodeficiency disease. 3.2.7 radiation pneumonitis.
        3.2.8 depends on oxygen. 3.2.9 four weeks into the set of other therapeutic studies or
        clinical trials. 3.2.10 used experimental vaccine in two months 3.2.11 systemic
        corticosteroids used within two weeks, hydroxyurea or immune inhibitors (such as IL - 2,
        Interferons alpha, IFN - gamma, GSF, mTOR inhibitors, ring spore element, etc.).Recently or
        are using suction The sex hormone. 3.2.12 year have chronic or recurrent severe autoimmune
        diseases. 3.2.13 uncontrolled active infection. 3.2.14 2-4 acute or persistent during graft
        versus host disease (GVHD). 3.2.15 serious heart disease, after treatment of the disease is
        still unstable, into the group of the first six months after myocardial infarction, and
        congestion Heart failure, unstable angina, symptoms of pericardial effusion or unstable
        arrhythmia.

        3.2.18 always suffer from other cancers, but does not include: A. basal cell carcinoma and
        squamous cell carcinoma after active treatment, the wound healed completely.

        B. the cervical or breast carcinoma in situ cure for at least three years. C. primary
        malignant tumors were removed completely, completely relieve five years or more.

        3.2.19 accompanied by primary or secondary brain tumor patients. 3.2.20 the mentally
        disabled. 3.2.21 doubt or have alcohol and drug abuse history. 3.2.22 physicians determine
        cannot or may not be able to complete the test subjects.

        3.2.23 any not listed may interfere with the patient to participate in the active disease.