Inclusion Criteria:

          1. Histologically or cytologically confirmed small cell lung cancer (SCLC) or other solid
             tumors

          2. Male or non-pregnant, non-lactating female patients age ≥18 years

          3. Locally advanced or metastatic disease for which no standard therapy is judged
             appropriate by the investigator

          4. Eastern Cooperative Oncology Group (ECOG) Performance Status < 2

          5. Adequate hematologic function as indicated by:

               1. Platelet count ≥ 100,000/mm˄3

               2. Hemoglobin ≥ 9.0g/dL Platelet count ≥ 100,000/mm˄3

               3. Absolute neutrophil count (ANC) ≥1000/µL

          6. Adequate renal and liver function as indicated by:

               1. Serum creatinine ≤ 1.5 x upper limit of normal (ULN); if serum creatinine is >1.5
                  X ULN, creatinine clearance must be ≥ 50 mL/min

               2. Total bilirubin ≤1.5 x ULN; If Gilbert's Syndrome may have Bilirubin> 1.5 x ULN

               3. Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ≤3 x ULN of
                  institution's normal range; for patients with known liver metastases, AST and ALT
                  may be ≤ 5 x ULN

               4. Coagulation: activated partial thromboplastin time (aPTT) and prothrombin time
                  (PT)<1.2 x the upper limit of normal

          7. Brain metastases with clinically controlled neurologic symptoms, defined as surgical
             excision and/or radiation therapy followed by 21 days of stable neurologic function
             and no evidence of CNS disease progression as determined by CT or MRI within 21 days
             prior to the first dose of study drug

          8. Willingness to use contraception by a method that is deemed effective by the
             investigator by both males and female patients of child bearing potential
             (postmenopausal women must have been amenorrheal for at least 12 months to be
             considered of non-childbearing potential) and their partners throughout the treatment
             period and for at least three months following the last dose of study drug

          9. Ability to understand and willingness to sign a written informed consent form

         10. Willingness and ability to comply with study procedures and follow-up examination

        Exclusion Criteria:

          1. Receiving concurrent anti-cancer therapy (chemotherapy, radiation therapy, surgery,
             immunotherapy, hormonal therapy, targeted therapy, biologic therapy, with the
             exception of hormones for hypothyroidism or estrogen replacement therapy (ERT), anti
             estrogen analogs, agonists required to suppress serum testosterone levels); or any
             investigational therapy, or has had tumor embolization or tumor lysis syndrome (TLS)
             within 14 days prior to the first dose of study drug

          2. Steroid therapy for anti-neoplastic intent within 7 days prior to the first dose of
             study drug

          3. Continuance of toxicities due to prior radiotherapy or chemotherapy agents that do not
             recover to < Grade 2

          4. Known bleeding diathesis/disorder

          5. Recent history of non-chemotherapy induced thrombocytopenia associated bleeding within
             1 year prior to first dose of study drug

          6. Have active immune thrombocytopenic purpura (ITP), active autoimmune hemolytic anemia
             (AIHA), or a history of being refractory to platelet transfusions (within 1 year prior
             to the first dose of study drug)

          7. Serious gastrointestinal bleeding within 3 months

          8. Use of therapeutic doses of anti-coagulants is excluded, along with anti-platelet
             agents; low-dose anticoagulation medications that are used to maintain the patency of
             a central intravenous catheter are permitted

          9. Received a biologic (G-CSF, GM-CSF or erythropoietin) within 28 days prior to the
             first dose of study drug

         10. Failure to recover adequately, as judged by the investigator, from prior surgical
             procedures. Patients who have had major surgery within 28 days from study entry, and
             patients who have had minor surgery within 14 days of study entry

         11. Unstable angina, myocardial infarction, or a coronary revascularization procedure
             within 180 days of study entry

         12. Neurologic instability per clinical evaluation due to tumor involvement of the central
             nervous system (CNS). Patients with CNS tumors that have been treated, are
             asymptomatic and who have discontinued steroids (for the treatment of CNS tumors) for
             >28 days may be enrolled

         13. Active symptomatic fungal, bacterial and/or viral infection including, but not limited
             to, active human immunodeficiency virus (HIV) or viral hepatitis (B or C)

         14. Diagnosis of fever and neutropenia within 1 week prior to study drug administration

         15. Uncontrolled concurrent illness including, but not limited to: serious uncontrolled
             infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
             arrhythmia, or psychiatric illness/social situations that would limit compliance with
             the study requirements

         16. Prior treatment with Bcl-2/Bcl-xL inhibitors

         17. Any other condition or circumstance of that would, in the opinion of the investigator,
             make the patient unsuitable for participation in the study

         18. Known clinically active hepatitis B or hepatitis C infection. Testing for hepatitis B
             and C is not required for study enrollment.

         19. Known HIV infection