Key Inclusion Criteria:

          -  Histologically confirmed unilateral primary invasive adenocarcinoma of the breast

          -  Estrogen receptor-positive and/or progesterone receptor-positive, HER2-negative breast
             cancer

          -  Patient is after surgical resection of the tumor where tumor was removed completely
             with surgical specimen microscopic margins free from tumor and with available archival
             tumor tissue from the surgical specimen

          -  Patient who have AJCC 8th edition Prognostic Stage Group II

          -  Patient has completed adjuvant radiotherapy (if indicated) according to the
             institutional guidelines prior to screening

          -  Patient may already have initiated adjuvant endocrine therapy (ET) at the time of
             randomization, but randomization must take place within 52 weeks of date of initial
             histological diagnosis of breast cancer and within 12 weeks of initiating ET

          -  ECOG Performance Status 0 or 1

          -  Adequate bone marrow and organ function

          -  Sodium, potassium, phosphorus, magnesium and total calcium laboratory values within
             normal limits

          -  QTcF interval < 450 msec and mean resting heart rate 50-90 bpm

        Key Exclusion Criteria:

          -  Prior neoadjuvant therapy (endocrine therapy or chemotherapy) or CDK4/6 inhibitor

          -  Prior treatment with tamoxifen, raloxifen or aromatase inhibitors for reduction in
             risk (chemoprevention) of breast cancer and/or treatment for osteoporosis within last
             2 years

          -  Patient with inflammatory breast cancer

          -  Prior treatment with anthracyclines at cumulative doses of 450 mg/m² or more for
             doxorubicin or 900 mg/m² or more for epirubicin

          -  Distant metastases of breast cancer beyond regional lymph nodes

          -  Patient has not recovered from clinical and laboratory acute toxicities of
             chemotherapy, radiotherapy and surgery

          -  Clinically significant, uncontrolled heart disease and/or cardiac repolarization
             abnormality, or clinically significant cardiac arrhythmias

          -  Uncontrolled hypertension with systolic blood pressure >160 mmHg

          -  Patient is currently receiving any of the prohibited substances that cannot be
             discontinued 7 days prior to Cycle 1 Day 1: concomitant medications, herbal
             supplements, and/or fruits and their juices that are known as strong inhibitors or
             inducers of CYP3A4/5; medications that have a narrow therapeutic window and are
             predominantly metabolized through CYP3A4/5; systemic corticosteroids ≤ 2 weeks prior
             to starting study drug, or who have not fully recovered from side effects of such
             treatment; concomitant medications with a known risk to prolong the QT interval and/or
             known to cause torsades de points that cannot be discontinued or replaced by safe
             alternative medication.

          -  Pregnant or breast-feeding (lactating) women or women who plan to become pregnant or
             breast-feed during the study

          -  Women of child-bearing potential unless they are using highly effective methods of
             contraception during the study treatment and for 21 days after stopping the study
             treatment.