The objective of this study is to evaluate the bioequivalence of a tablet formulation versus
a capsule formulation of ASP8273 following a single dose under fasted condition in subjects
with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR)
mutations. The study will also evaluate the safety and tolerability of a tablet formulation
as a single dose and a capsule formulation as a single and multiple dose of ASP8273 in
subjects with NSCLC harboring EGFR mutations.
Study and subjects will be divided into two phases: a pharmacokinetic (PK) and a
postpharmacokinetic phase. The pharmacokinetic phase will follow a randomized, 2 period, 2
sequence single dose crossover design. Each period will be 5 days in duration. Within the
sequence, both an ASP8273 tablet and ASP8273 capsule will be administered under fasted
condition. The postpharmacokinetic phase will consist of up to 1 cycle (28 days) of
continuous once daily dosing in post PK phase with ASP8273 capsules. Dose modifications are
allowed if necessary in post PK phase and they follow a step-wise dose reduction. Subject is
able to re-escalate dose level if reaction is stable.
Inclusion Criteria:
- Subject has histologically confirmed locally advanced or unresectable Stage IIIB (not
amenable to receive curative treatments such as chemo-radiation)/IV or metastatic
NSCLC.
- Subject has Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
- Subject has an EGFR activating mutation based on local testing.
- Subject has predicted life expectancy ≥ 12 weeks.
- Subject must meet all of the following criteria on the laboratory tests. In case of
multiple laboratory data within this period, the most recent data should be used.
- Neutrophil count > 1000/mm^3
- Platelet count ≥ 7.5 x 10^4/mm^3
- Hemoglobin > 8.0 g/dL
- Serum creatinine <2.0 x upper limit of normal (ULN) or estimated glomerular
filtration rate of > 50 mL/min as calculated by the Cockcroft Gault Method
- Total bilirubin < 1.5 × ULN (except for subjects with documented Gilbert's
syndrome)
- AST (Aspartate aminotransferase (GOT) and ALT (Alanine aminotransferase (GPT)) <
3.0 × ULN (upper limit of normal) or ≤ 5 × ULN if subject has documented liver
metastases
- Serum sodium level ≥ 130 mmol/L
- Subject agrees not to participate in another interventional study while receiving
study drug and participating in the present study.
- Female subject must either:
- Be of nonchildbearing potential:
- Postmenopausal (defined as at least 1 year without any menses) prior to
screening, or
- Documented surgically sterile (e.g., hysterectomy, bilateral salpingectomy,
bilateral oophorectomy) Or, if of childbearing potential,
- Agree not to try to become pregnant during the study and for 28 days after the
final study drug administration
- And have a negative blood pregnancy test at the time of screening
- And if heterosexually active, agrees to consistently use 1 form of highly
effective birth control* starting at screening and throughout the study period
and for 28 days after the final study drug administration.
- Female subject must agree not to breastfeed at screening and throughout the study
period, and for 28 days after the final study drug administration.
- Female subject must not donate ova starting at screening and throughout the study
period, and for 28 days after the final study drug administration.
- A sexually active male subject with female partner(s) who are of childbearing
potential is eligible if:
- Agrees to use a male condom starting at screening and continue throughout study
treatment and for 90 days after the final study drug administration. If the male
subject has not had a vasectomy or is not sterile as defined below their female
partner(s) is utilizing 1 form of highly effective birth control*starting at
screening and continue throughout study treatment and for 90 days after the male
subject receives their final study drug administration.
- Male subject with a pregnant or breastfeeding partner(s) must agree to remain
abstinent or use a condom for the duration of the pregnancy or time partner is
breastfeeding throughout the study period and for 90 days after the final study drug
administration
- Male subject must not donate sperm starting at screening and throughout the study
period, and for 90 days after the final study drug administration.
- Subject must be willing to fast for approximately 10 hours predose and 4 hours
postdose on day 1 of each period in the pharmacokinetic phase.
- Highly effective forms of birth control include:
- Consistent and correct usage of established hormonal contraceptives that
inhibit ovulation,
- Established intrauterine device or intrauterine system.
- Vasectomy (A vasectomy is a highly effective contraception method provided
the absence of sperm has been confirmed. If not, an additional highly
effective method of contraception should be used).
- Male subject is sterile due to a bilateral orchiectomy.
Exclusion Criteria:
- Subject has an ongoing toxicity ≥ Grade 2 (NCI CTCAE Version 4.03) attributable to
prior medication to treat solid tumor (except alopecia) at screening.
- Subject has received investigational therapy within 28 days or 5 half-lives, whichever
is longer, prior to the first dose of study drug.
- Subject has received treatment with any other agent with antitumor activity including
chemotherapy, radiotherapy, or immunotherapy within 14 days as well as EGFR tyrosine
kinase inhibitor within 6 days prior to first dose of study drug.
- Subject has any of the following within 14 days prior to the first dose of study drug:
- Major surgical procedure (other than study related biopsy), or a major surgical
procedure is planned to occur during the planned study duration
- Blood transfusions or hemopoietic factor therapy
- Evidence of active infection requiring systemic therapy
- Subject has symptomatic central nervous system (CNS) metastasis. Subject with
previously treated brain or CNS metastases is eligible provided that the subject has
recovered from any acute effects of radiotherapy and is not requiring systemic
steroids and any whole brain radiation therapy was completed at least 2 weeks prior to
study drug administration, or any stereotactic radiosurgery was completed at least 1
week prior to study drug administration.
- Subject has a known history of a positive test for human immunodeficiency infection.
- Subject has a known history of a positive test for hepatitis B surface antigen or
hepatitis C antibody.
- Subject has known history of serious hypersensitivity reaction to ASP8273, or any
component of the formulation used.
- Subject has severe or uncontrolled systemic diseases including uncontrolled
hypertension or active bleeding diatheses.
- Subject has history of drug-induced interstitial lung disease (ILD) or any evidence of
active ILD.
- Subject has ongoing cardiac arrhythmia that is Grade ≥ 2 or uncontrolled atrial
fibrillation of any grade.
- Subject currently has Class III or IV New York Heart Association congestive heart
failure.
- Subject has history of severe/unstable angina, myocardial infarction or
cerebrovascular accident within 6 months prior to the planned first dose of study
drug.
- Subject has active gastrointestinal ulcer or gastrointestinal bleeding within 3 months
prior to the planned first dose of study drug.
- Subject has concurrent corneal disorder or any ophthalmologic condition that makes the
subject unsuitable for study participation (e.g., advanced cataracts, glaucoma).
- Subject has difficulty taking oral medication or any digestive tract dysfunction or
inflammatory bowel disease that would interfere with the intestinal absorption of
drug.
- Subject has another past or active malignancy that requires treatment. Prior carcinoma
in situ and/or nonmelanoma skin cancer after curative resection are permitted.
- Subject has received the following within 14 days prior to the first dose of study
drug:
- Strong or moderate CYP3A4 inhibitors or inducers
- Strong or moderate P-gp inhibitors or inducers
