Inclusion Criteria:

          -  Age ≥ 12 years

          -  Histologically confirmed diagnosis of grade 2 or 3 out of 3 UPS or
             dedifferentiated/pleomorphic LPS of the extremity (including limb girdle, i.e.
             shoulder or hip) that measures greater than 5 cm in any direction as assessed by
             imaging

          -  Patients with non-melanomatous skin cancer, in situ carcinoma, or low-risk prostate
             cancer can be enrolled.

          -  ECOG Performance Status of 0 or 1

          -  Resectable primary tumor with no evidence of metastatic disease by imaging.

          -  Adequate organ function within 10 days of Day 1

          -  Written, voluntary informed consent

          -  Fertile men and women of childbearing potential must agree to use an effective method
             of birth control from Day 1 of study and for 120 days after last pembrolizumab
             administration in both sexes. Women of childbearing potential include pre-menopausal
             women and women within the first 2 years of the onset of menopause. Women of
             childbearing potential must have a negative pregnancy test ≤ 72 hours prior to Day 1
             of study.

        Exclusion Criteria:

          -  Prior chemotherapy, targeted small molecule therapy, or radiation therapy for current
             diagnosis of sarcoma

          -  Prior radiation therapy in excess of 20 Gy to the site of the current diagnosis of
             sarcoma. No overlap with prior radiation fields in excess of 20 Gy is allowed.

          -  Concurrent, clinically significant, active malignancies within two years of study
             enrollment.

          -  Patients with locally recurrent sarcoma after surgery alone are eligible for
             enrollment if other inclusion criteria are met.

          -  Patients with severe and/or uncontrolled concurrent medical disease that in the
             opinion of the investigator could cause unacceptable safety risks or compromise
             compliance with the protocol

          -  Major surgery within four weeks prior to Day 1 of study or who have not recovered
             adequately from prior surgery.

          -  Currently receiving a study therapy or if they had an investigational agent within 4
             weeks at the time of enrollment.

          -  Women who are pregnant or nursing/breastfeeding, or expecting to conceive or men who
             are expecting to father children within the projected duration of the trial, starting
             with the pre-screening or screening visit through 120 days after the last dose of
             pembrolizumab.

          -  Inability to comply with protocol required procedures

          -  Diagnosis of immunodeficiency or is receiving systemic steroid therapy or any other
             form of immunosuppressive therapy by oral or IV routes within 7 days prior to the
             first dose of trial treatment

          -  Known history of active TB (Bacillus Tuberculosis)

          -  Hypersensitivity to pembrolizumab or any of its excipients

          -  Metastatic disease or regional lymph node involvement. Chest CT will be mandatory
             prior to enrollment to evaluate for the presence of metastatic disease. Pulmonary
             nodule(s) < 5 mm without a histological diagnosis may not be the basis for study
             exclusion given the lack of specificity of chest CT. If pulmonary nodule(s) measuring
             6 - 10 mm are noted on chest CT but appear stable relative to prior chest imaging of
             at least 6 months duration or if 18FDG-PET scan indicates that the nodule(s) are
             unlikely to be metastatic disease, then this is permitted. Pulmonary nodules >10 mm
             should be considered metastatic unless proven otherwise by biopsy/resection or stable
             appearance for at least 6 months on imaging.

          -  Unresectable disease or medically inoperable

          -  Planned to receive neoadjuvant or adjuvant chemotherapy for current diagnosis of
             localized soft tissue sarcoma

          -  Active autoimmune disease that has required systemic treatment in the past two years
             (i.e. with use of disease modifying agents, systemic corticosteroids or
             immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or
             physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency,
             etc.) is not considered a form of systemic treatment.

          -  Has a history of (non-infectious) pneumonitis that required systemic steroids or
             current pneumonitis.

          -  Active infection requiring systemic therapy

          -  Known psychiatric or substance abuse disorders that would interfere with cooperation
             with the requirements of the trial

          -  Prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent

          -  Known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies)

          -  Known active Hepatitis B (e.g., HBsAg reactive, confirmed by detectable viral load) or
             Hepatitis C (e.g., HCV RNA [qualitative] detected)

          -  Received a live vaccine within 30 days of planned start of study therapy. Note:
             Seasonal influenza vaccines for injection are generally inactivated flu vaccines and
             are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live
             attenuated vaccines, and are not allowed.

          -  Diagnosis of scleroderma.

          -  Diagnosis of inflammatory bowel disease (Crohn's disease or Ulcerative Colitis).