Inclusion Criteria:

          -  Has at least 1 measurable ccRCC tumor and no solid ccRCC tumor greater than 3.0 cm,
             based on radiologic diagnosis (histologic diagnosis not required); may have VHL
             disease-associated lesions in other organ systems

          -  Has a diagnosis of von Hippel Lindau disease, based on a germline VHL alteration

        Exclusion Criteria:

          -  Has had prior radiotherapy or systemic anti cancer therapy for ccRCC (includes
             anti-VEGF therapy or any systemic investigational anti cancer agent)

          -  Has a prior or concomitant non-VHL disease-associated invasive malignancy with the
             exception of adequately treated basal or squamous cell carcinoma of the skin, cervical
             carcinoma in situ or any other malignancy from which the patient has remained disease
             free for more than 2 years

          -  Has any history of metastatic disease

          -  Has had radiotherapy to any non-ccRCC site within 4 weeks prior to entering the study
             or has not recovered from adverse events (AE)

          -  Has had any surgical procedure for VHL disease or any major surgical procedure
             completed within 4 weeks prior to entering the study or has any surgical lesions from
             recent major surgical procedures that are not well healed