Inclusion Criteria:

          1. Age 18-65 years

          2. Patients with AML or MDS who meet the following criteria:

             a. Relapsed or refractory AML (including AML in CR2)

             b. Poor-risk AML in first remission, with remission defined as <5% bone marrow blasts
             morphologically:

               -  AML arising from MDS or a myeloproliferative disorder, or secondary AML

               -  Poor risk molecular features including presence of FLT3 internal tandem
                  duplication mutation.

               -  Poor-risk cytogenetics: Monosomal karyotype, complex karyotype (> 3
                  abnormalities), inv(3), t(3;3), t(6;9), MLL rearrangement with the exception of
                  t(9;11), or abnormalities of chromosome 5 or 7

                  c. Primary refractory disease

                  d. MDS with at least one of the following poor-risk features:

               -  Poor-risk cytogenetics including 3q abnormalities, 7/7q minus or complex
                  cytogenetics (>3 abnormalities)

               -  Current or previous INT-2 or high IPSS score

               -  Treatment-related MDS

               -  MDS diagnosed before age 21 years

               -  Progression on or lack of response to standard DNA-methyltransferase inhibitor
                  therapy

               -  Life-threatening cytopenias, including those requiring regular PRBC or platelet
                  transfusions e. CML with a history of accelerated or blast phase

          3. Patients must have a related or unrelated peripheral blood stem cell donor as follows:

               1. Sibling donor must be a 6/6 match for HLA-A, -B at intermediate (or higher)
                  resolution and -DRB1 at high resolution using DNA based typing

               2. Unrelated donors must be at least 7/8 match at HLA-A, -B, -C and DRB1 at high
                  resolution using DNA-based typing

        Exclusion criteria:

          1. Presence of significant co morbidity as shown by:

               1. Left ventricular ejection fraction < 50%

               2. Creatinine clearance <30ml/min

               3. Bilirubin > 2.0 mg/dL (unless due to Gilbert's syndrome or hemolysis), and ALT
                  and AST > 5 x ULN

               4. FEV1 and FVC < 50% of predicted or DLCO <50% of predicted once corrected for
                  anemia

             f. Karnofsky score <70 (appendix C)

             g. Hematopoietic cell transplantation comorbidity index >3

             h. Active viral hepatitis or HIV infection

             j. Cirrhosis

          2. Pregnancy

          3. Patients unable to sign informed consent

          4. Patient who have previously received radiation to >20% of bone marrow containing
             areas.

        4. DONOR ELIGIBILITY AND SELECTION

        4.1. Donor Selection

        Donor evaluation and selection is by standard for normal clinical practice. No study
        procedures are to be performed on donors. All donors must be willing to donate peripheral
        blood stem cells and meet institutional or NMDP criteria for donation.

        The following prioritization will be used when selecting donors:

          1. When possible, an HLA compatible sibling will be used as a donor.

          2. For patients who do not have an HLA compatible sibling, an unrelated donor will be
             used

          3. 8/8 matched unrelated donors are preferred over single antigen mismatched donors.

        If more than one potential volunteer unrelated donor is considered suitable further
        selection of the most suitable donor is at the discretion of the treating physician. The
        following serves only as a guide for prioritization:

          1. Age of donor (18-24 > 25-34 > 35-44 > 45+)

          2. Sex and parity of donor (male > female, nulliparous female > parous, multiparous
             female)

          3. Cytomegalovirus (CMV) status, if recipient is CMV seronegative (CMV- > CMV+)