Inclusion Criteria:

          -  Pathologically documented non-small cell carcinoma (cytology or histology) that is
             accessible via standard-of-care staging procedures: (1) EBUS or (2) surgical
             approaches (eg mediastinoscopy, mediastinotomy or VATS).

          -  Resectable with negative lymph nodes based on imaging with histologic confirmation at
             time of the staging procedure prior to AdV-tk injection

          -  The tumor must be 4cm or greater in diameter based on imaging

          -  ECOG Performance status of 0 or 1.

          -  Granulocyte count (ANC) ≥ 1,000/mm3

          -  Peripheral lymphocyte count ≥ 500/mm3

          -  Hemoglobin ≥ 9 g/dl

          -  Platelets ≥ 100,000/mm3

          -  Total bilirubin ≤ 1.5 x upper limit of normal

          -  SGOT (AST) ≤ 3x upper limit of normal

          -  Serum creatinine < 2mg/dl

          -  Calculated creatinine clearance > 30ml/min

          -  Patients must give study specific informed consent prior to enrollment

        Exclusion Criteria:

          -  Radiotherapy and/or treatment with chemotherapeutic, cytotoxic, or immunologic agents
             within 4 weeks prior to infusion of the vector.

          -  Known immunodeficiency such as HIV infection

          -  Active liver disease, including known cirrhosis or active hepatitis

          -  Use of systemic corticosteroids (>10 mg prednisone per day or equivalent) or other
             systemic immunosuppressive drugs

          -  Patient is pregnant or breast-feeding. Female patients of childbearing age must have
             negative serum or urine pregnancy test within 1 week of beginning therapy. Subjects
             must use acceptable means of birth control until 30 days after the vector injection.

          -  Presence of any other life-threatening illness, such as unstable angina, severe oxygen
             dependence, significant chronic obstructive pulmonary disease (COPD), end-stage liver
             or renal disease. COPD will be considered significant if disease limits activities of
             daily living, results in the inability to walk up 1 flight of stair, or requires home
             oxygen.

          -  Presence of known untreated brain metastases.

          -  Prior bone marrow transplants (including stem cells) except autologous stem cell
             transplant without immunosuppression is NOT considered an exclusion.

          -  Known sensitivity or allergic reactions to valacyclovir