Inclusion Criteria:

          1. Histologically confirmed diagnosis of metastatic or locally advanced unresectable
             tumors

          2. Patients demonstrating disease progression after treatment with available therapies
             that are known to confer clinical benefit, or who are intolerant to treatment,

          3. Agreement to provide mandatory archival tissue or fresh biopsy.

          4. At least 18 years of age.

        Exclusion Criteria:

          1. Active or chronic corneal disorder, history of corneal transplantation, active
             herpetic keratitis, and active ocular conditions requiring ongoing
             treatment/monitoring

          2. Serious concurrent illness, including clinically relevant active infection

          3. History of or current active autoimmune diseases

          4. Significant cardiac disease such as recent myocardial infarction

          5. History of multiple sclerosis or other demyelinating disease, Eaton-Lambert syndrome
             (para-neoplastic syndrome), history of hemorrhagic or ischemic stroke within the last
             6 months, or alcoholic liver disease;

          6. Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the
             underlying neoplasm;

          7. History of severe allergic or anaphylactic reactions to previous monoclonal antibody
             therapy;

          8. Currently receiving anticoagulation therapy with warfarin;

          9. Major surgery (requiring general anesthesia) within 3 months prior to dosing.