Inclusion Criteria:

          -  Patients aged from 18 to 70 years old.

          -  Patients with a unifocal Glioblastoma (grade IV astrocytoma in the World Health
             Organization (WHO) classification) with postoperative macroscopic residue after biopsy
             or resection alone.

          -  Location of the tumor or residual tumor, detected by Magnetic Resonance Imaging (MRI)
             sequences T1 gadolinium, more than 1cm from the optic chiasm

          -  Diagnosis confirmed by pathology.

          -  Time from surgery (if performed) and the start of radiation therapy less than 6 weeks.

          -  performance status 0 or 1 in the WHO classification.

          -  methylation status of the MGMT promoter gene requested

          -  blood count: Neutrophil more than 1500/mm3 Platelets more than 100 000/mm3

          -  Liver function test Bilirubin less than 1,5 times upper limit transaminases than 3
             times upper limit

          -  patient informed and informed consent signed

          -  Possibility to trat by radiation withintensity modulated (fixed beams modulated or
             rotational modulation (TomoTherapy, dynamic arctherapy)) strictly respecting the
             constraints to organs at risk (Crystalline: 8 Gy max, Posterior chamber of the eye: 45
             Gy max , optic nerve: 54 Gy max, chiasm: 54 Gy max, brain Stem: 2% 58 Gy D2 <64 Gy,
             Dmax <69 Gy spinal cord: 46 Gy max, healthy brain (brain - PTV): 60 Gy max 33%, 50 Gy
             to 50% and D100 <45 Gy to the brain in toto).

          -  The patient must be affiliated to a social security scheme.

        Exclusion Criteria:

          -  Other histological "Glioblastoma".

          -  Excision macroscopically complete individualized on postoperative MRI.

          -  Patient unable to give consent.

          -  A patient with against-indication to performed MRI (pacemaker, uncontrollable
             claustrophobia ...).

          -  The patient must not have received radiation therapy or previous chemotherapy for this
             condition.

          -  Other neoplasia unstabilized and / or treated for less than 5 years.

          -  Patient already included in another clinical trial with an experimental molecule.

          -  Inability to submit to medical monitoring testing for geographical, social or
             psychological.

          -  Pregnancy or breastfeeding

          -  Private Person of liberty under supervision or under curatorship

          -  No affiliation to a social security scheme or medical state aid or the universal
             medical coverage