Clinical Trials /

Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic Cancer

NCT03186326

Description:

Immune chekpoints (ICI) are evaluated in many digestive cancers. Certain types of cancer appear to be rather refractory to ICI such as colorectal cancers (CRC). However, the MSI CRC representing approximately 15% of the CRCs exhibits a high mutational load which generates many potentially immunogenic neoantigens. In addition, strong expression of PD-L1 was found in the MSI CRCs relative to the CRC (MSS) stages. Localized MSI CRCs have a better prognosis than MSS CRCs, probably due to immunogenic neoantigens associated with a CD8 + T-specific immune response. On the oher hand, in metastatic CRC (mCRC) things are different because i) the MSI frequency is only 4 to 7% and ii) the good prognosis conferred by the MSI status is controversial. Preliminary results suggest that patients with MSI mCRC are highly sensitive to ICI even chemoresistant tumors receiving several lines of chemotherapy. Recently, another anti-PD1 alone or in combination with an anti-CTLA4 (antigen associated with cytotoxic T-lymphocyte 4) was tested in the MSI CRCs and a selection of interesting results in heavily pretreated patients with a disease control rate of 56% for monotherapy and 81% for combinated therapy. Anti-PD1s now have marketing authorization for patients with melanoma and metastatic pulmonary carcinoma , Which are known to have a high level of mutations . ICIs appear to be as promising in MSI CRCs as in other tumors and therefore face the same major challenges. Avalumab is an anti-PD-L1 antibody recently tested in several different types of tumors with promising results and is currently being studied in phase III in gastric cancer. There is no data on the effectiveness of this ICI in the MSI mCRCs. In addition, only anti-PD1 was used in the MSI-mCRC and not the anti-PD-L1, and only in chemoresistance (3rd line or more). The main objective of the SAMCO study is to test the efficacy and tolerance of avelumab in the 2nd line of treatment in patients with a MSI mCRC progression after standard 1st line chemotherapy +/- targeted therapy.

Related Conditions:
  • Colorectal Adenocarcinoma
Recruiting Status:

Recruiting

Phase:

Phase 2

Trial Eligibility

Document

Title

  • Brief Title: Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic Cancer
  • Official Title: Multicenter Randomized Phase II Study Comparing the Effectiveness and Tolerance of Avelumab Versus Standard 2nd Line Treatment Chemotherapy in Patients With Colorectal Metastatic Cancer With Microsatellite Instability (MSI)

Clinical Trial IDs

  • ORG STUDY ID: PRODIGE 54 - FFCD 1603
  • NCT ID: NCT03186326

Conditions

  • Metastatic Colorectal Cancer
  • MSI

Interventions

DrugSynonymsArms
FOLFOX regimenArm A Chemotherapy (standard treatment)
FOLFIRI ProtocolArm A Chemotherapy (standard treatment)
AvelumabArm B - Immunotherapy (experimental arm)
PanitumumabArm A Chemotherapy (standard treatment)
CetuximabArm A Chemotherapy (standard treatment)
BevacizumabArm A Chemotherapy (standard treatment)
AfliberceptArm A Chemotherapy (standard treatment)

Purpose

Immune chekpoints (ICI) are evaluated in many digestive cancers. Certain types of cancer appear to be rather refractory to ICI such as colorectal cancers (CRC). However, the MSI CRC representing approximately 15% of the CRCs exhibits a high mutational load which generates many potentially immunogenic neoantigens. In addition, strong expression of PD-L1 was found in the MSI CRCs relative to the CRC (MSS) stages. Localized MSI CRCs have a better prognosis than MSS CRCs, probably due to immunogenic neoantigens associated with a CD8 + T-specific immune response. On the oher hand, in metastatic CRC (mCRC) things are different because i) the MSI frequency is only 4 to 7% and ii) the good prognosis conferred by the MSI status is controversial. Preliminary results suggest that patients with MSI mCRC are highly sensitive to ICI even chemoresistant tumors receiving several lines of chemotherapy. Recently, another anti-PD1 alone or in combination with an anti-CTLA4 (antigen associated with cytotoxic T-lymphocyte 4) was tested in the MSI CRCs and a selection of interesting results in heavily pretreated patients with a disease control rate of 56% for monotherapy and 81% for combinated therapy. Anti-PD1s now have marketing authorization for patients with melanoma and metastatic pulmonary carcinoma , Which are known to have a high level of mutations . ICIs appear to be as promising in MSI CRCs as in other tumors and therefore face the same major challenges. Avalumab is an anti-PD-L1 antibody recently tested in several different types of tumors with promising results and is currently being studied in phase III in gastric cancer. There is no data on the effectiveness of this ICI in the MSI mCRCs. In addition, only anti-PD1 was used in the MSI-mCRC and not the anti-PD-L1, and only in chemoresistance (3rd line or more). The main objective of the SAMCO study is to test the efficacy and tolerance of avelumab in the 2nd line of treatment in patients with a MSI mCRC progression after standard 1st line chemotherapy +/- targeted therapy.

Trial Arms

NameTypeDescriptionInterventions
Arm A Chemotherapy (standard treatment)Active ComparatorFOLFOX or FOLFIRI +/- targeted therapy
  • FOLFOX regimen
  • FOLFIRI Protocol
  • Panitumumab
  • Cetuximab
  • Bevacizumab
  • Aflibercept
Arm B - Immunotherapy (experimental arm)ExperimentalAvelumab
  • Avelumab

Eligibility Criteria

        Inclusion Criteria:

          -  Histologically proven colorectal adenocarcinoma with metastasis(es) non-resectable

          -  MSI-H determined by immunohistochemistry (loss of expression of MLH1, MSH2, MSH6
             and/or PMS2) or by molecular biology

          -  At least one measurable target (primary tumor or metastasis) according to RECIST v1.1

          -  Mutational status RAS and BRAF

          -  Age ≥ 18

          -  OMS ≤ 2

          -  Life expectancy < 3 months

          -  Patient failure (progression or unacceptable toxicity) of chemotherapy containing
             fluoropyrimidine (capecitabine or 5FU) +/- irinotecan +/- oxaliplatin with or without
             cetuximab, bevacizumab and panitumumab (patients in progression during or within 3
             months after discontinuation of adjuvant chemotherapy are eligible)

          -  PNN > 1500/mm3, platelets > 100 000/mm3, Hb > 9 g/dL

          -  Total bilirubin < 25 µmol/L, ASAT < 5x LSN, ALAT < 5 x LSN, PT > 60%,

          -  Creatinine clearance > 50 ml/min according to MDRD formula (≥ 30 ml/min according to
             the Cockcroft-Gault formula)

          -  Patient belonging to a social security scheme

          -  Patient information and signature of the informed consent

        Exclusion Criteria:

          -  Patient immediately eligible for a curative therapy (surgical and/or percutaneous)
             after discussion in CPR

          -  Patient treated with FOLFIRINOX or FOLFOXIRI in 1st line

          -  Cerebral metastasis

          -  Previous treatment with anti-PD1 or anti-PDL1

          -  Autoimmune disease that might be aggravated during treatment with an
             immuno-stimulating agent (patients with type I diabetes, vitiligo, psoriasis, hypo- or
             hyperthyroid disease not requiring immunosuppressive treatment are eligible)

          -  Immunosuppressive long-term treatment (patients necessitating a corticotherapy are
             eligible if they are administered in doses < or = to the equivalent of 10 mg of
             prednisone daily, administration of steroids by a route resulting in minimal systemic
             exposure (local, intra-anal, intraocular or inhalation) are eligible).

          -  Transplant patients (including stem cell transplants), HIV positive or other immune
             deficiency syndromes

          -  Active infection by HBV or HCV

          -  Known severe hypersensitivity to monoclonal antibodies or history of anaphylactic
             shock, or uncontrolled asthma

          -  Any known specific contraindication or allergy to the treatments used in the study

          -  Persistence of toxicities related to 1st line chemotherapy grade > 2 (NCI-CTC v4.0)
             (except alopecia and neuropathy sequelae of oxaliplatin)

          -  Vaccination during the 4 weeks preceding the start of treatment

          -  Known deficit in DPD

          -  QT/QTc interval > 450 msec for men and > 470 msec for women

          -  K+ < LIN, Mg2+ < LIN, Ca2+ < LIN

          -  Following alterations in the 6 months prior to inclusion: myocardial infarction,
             angina, severe/unstable angina, coronary artery bypass surgery, congestive heart
             failure NYHA class II, III or IV, stroke or transient ischemic attack

          -  Any progressive pathology not stabilised over the past 6 months: hepatic failure,
             renal failure, respiratory failure

          -  Patient with interstitial pneumonitis or pulmonary fibrosis

          -  History of chronic diarrhea or inflammatory disease of the colon or rectum, or
             unresolved occlusion or sub-occlusion in symptomatic treatment

          -  History of malignant pathologies during the past 5 years except basocellular skin
             carcinoma or in situ cervical carcinoma, properly treated

          -  Patient already included in another clinical trial during treatment with an
             experimental molecule for L2

          -  Lack of effective contraception in patients (men and/or women) of childbearing age,
             pregnant or breastfeeding women, women of childbearing age not having had a pregnancy
             test

          -  Persons deprived of liberty or under supervision

          -  Impossibility of undergoing medical monitoring during the trial for geographic, social
             or psychological reasons
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:radiographic progression-free survival (PFS) by central review
Time Frame:From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 84 months
Safety Issue:
Description:Compare between the two treatment arms (arm A: 2nd line chemotherapy, arm B: avelumab) progression-free survival by central review

Details

Phase:Phase 2
Primary Purpose:Interventional
Overall Status:Not yet recruiting
Lead Sponsor:Federation Francophone de Cancerologie Digestive

Trial Keywords

  • immunotherapy
  • second line

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