Inclusion Criteria:

          -  signed inform consent form(ICF)

          -  Aged 18-75 years, male or female

          -  Histologically or cytologically documented inoperable, local advanced (stage IIIB),
             metastatic (stage IV), or recurrent non-squamous NSCLC

          -  At least one measurable lesion according to Response Evaluation Criteria In Solid
             Tumors（RECISIT） v 1.1

          -  Eastern Cooperative Oncology Group(ECOG) performance status of 0 or 1

          -  Life expectancy ≥ 12 weeks

          -  Patients of childbearing potential must agree to use effective contraceptive measures
             during study treatment and for 6 months after receiving last study treatment

        Exclusion Criteria:

          -  Mixed non-small cell lung cancer with squamous cell carcinoma component, or small cell
             carcinoma

          -  Patients with known ALK or ROS1 rearrangement

          -  History of hemoptysis within 3 months prior to screening with blood volume more than
             2.5 mL

          -  Evidence of tumor invading major blood vessels on imaging

          -  Patients with brain metastasis, spinal cord compression or carcinomatous meningitis
             history

          -  Uncontrolled hypertension, prior history of hypertensive crisis and hypertensive
             encephalopathy

          -  Clinically significant cardiovascular disease but not limited to active infections;
             unstable angina; stroke or transient cerebral ischemia; myocardial infarction;
             congestive heart-failure; serious cardiac arrhythmia, hepatic, renal or metabolic
             disease requiring medication during the study

          -  History of radical radiotherapy to the thorax within 6 months

          -  Serious, non-healing wound, active ulcer, or untreated bone fracture, or major
             surgical procedure within 28 days prior to randomization or anticipation of need for
             major surgery during the course of the study

          -  Recent or current treatment with aspirin or other non-steroidal anti-inflammatory
             drugs (NSAID) known to inhibit platelet function within 10 days prior to first dose of
             study treatment

          -  Recent or current treatment with anticoagulants or thrombolytic agent within 10 days
             prior to first dose of study treatment