Inclusion Criteria:

          -  Signed written informed consent.

          -  Male or female subjects aged greater than or equal to 18 years.

          -  For NSCLC: Histologically or cytologically confirmed diagnosis of unresectable
             recurrent or metastatic non-small cell lung cancer.

          -  For CRC: Histologically confirmed diagnosis of recurrent or metastatic colorectal
             cancer assessed as microsatellite instability-high (MSI-H) or mismatch repair
             deficient (dMMR).

          -  For EC: Histologically or cytologically confirmed advanced, recurrent or metastatic
             endometrial carcinoma.

          -  For cSCC: Histologically confirmed diagnosis of unresectable or metastatic cutaneous
             squamous cell carcinoma not amenable to local therapy.

          -  For SCLC: Histologically or cytologically confirmed diagnosis of unresectable small
             cell lung cancer.

          -  For MPM: Histologically or cytologically confirmed diagnosis of unresectable malignant
             pleural or peritoneal mesothelioma.

          -  For HNSCC: Histologically or cytologically confirmed diagnosis of recurrent or
             metastatic HNSCC (oral cavity, pharynx, larynx), stage III/IV and not amenable to
             local therapy with curative intent (surgery or radiation therapy with or without
             chemotherapy).

          -  For MEL: Histologically confirmed diagnosis of unresectable Stage III or metastatic
             melanoma not amenable to local therapy (excluding uveal or ocular melanoma).

          -  For MCC: Histologically confirmed diagnosis of metastatic Merkel cell carcinoma not
             amenable to local therapy.

          -  For RCC: Histologically confirmed diagnosis of renal cell carcinoma (with clear cell
             component) with advanced or metastatic disease that is not amenable to cure by surgery
             or other means.

          -  For UC: Histologically or cytologically documented locally advanced or metastatic
             transitional cell carcinoma of the urothelium (including renal pelvis, ureters,
             urinary bladder, urethra) not amenable to cure by surgery or other means.

          -  For HL: Histologically confirmed primary diagnosis of classical Hodgkin's lymphoma.

          -  For B-cell NHL: Histologically confirmed diagnosis of non-Hodgkin lymphoma.

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 at trial entry
             and an estimated life expectancy of at least 3 months

          -  Must have at least one measurable lesion based on RECIST 1.1.

          -  Have provided a formalin fixed tumor tissue sample from a biopsy of a tumor lesion
             either at the time of or after the diagnosis of metastatic disease has been made AND
             from a site not previously irradiated.

          -  Adequate hematological, hepatic and renal function as defined in the protocol.

          -  Effective contraception for both male and female subjects if the risk of conception
             exists.

          -  Other protocol defined inclusion criteria could apply.

        Exclusion Criteria:

          -  Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, anti-CTLA-4
             antibody, or any other antibody or drug specifically targeting T-cell co-stimulation
             or immune checkpoint pathways.

          -  Concurrent treatment with a non-permitted drug.

          -  History of severe hypersensitivity reactions to other monoclonal antibodies.

          -  Prior malignancy active within the previous 2 years except for locally curable cancers
             that have been apparently cured, such as basal or squamous cell skin cancer,
             superficial bladder cancer or carcinoma in situ of the cervix or breast, or localized
             prostate cancer.

          -  Chemotherapy, radioactive, biological cancer therapy, or tyrosine kinase inhibitor
             (TKI) therapy, within four weeks prior to the first dose of study drug, or who has not
             recovered to NCI CTCAE Grade 1 or better from the AEs due to cancer therapeutics
             administered more than four weeks earlier.

          -  Significant acute or chronic infections as defined in the protocol.

          -  Active or history of interstitial lung disease (ILD), or has had a history of
             pneumonitis that has required oral or IV steroids.

          -  Active or suspected autoimmune disease or a documented history of autoimmune disease.

          -  Known current drug or alcohol abuse.

          -  Underlying medical conditions that will make the administration of study drug
             hazardous or obscure the interpretation of toxicity determination or adverse events.

          -  Use of other investigational therapy within 28 days before study drug administration.

          -  Pregnant or breastfeeding.

          -  Uncontrolled or significant cardiovascular disease.

          -  Psychiatric illness or social situation that would preclude study compliance.

          -  Receipt of live, attenuated vaccine within 28 days prior to the first dose of study
             drug.