Inclusion Criteria:

          1. Subject has histologically or cytologically documented diagnosis of pancreatic
             adenocarcinoma with metastatic disease. Locally advanced subjects are not eligible.

          2. Subject must have measureable disease by RECIST 1.1.

          3. Subjects must be age 18 years or older.

          4. Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status of
             0 or 1.

          5. Subjects must have the following laboratory values at screening within 2 weeks of the
             first dose of investigational agents:

               -  Absolute neutrophil count (ANC) ≥1.5 x 109/L (in absence of growth factor
                  support)

               -  Platelet count ≥150 x 109/L

               -  Hemoglobin ≥9 g/dL(without transfusion support)

               -  Serum creatinine ≤1.5 mg/dL, and creatinine clearance ≥ 50 ml/min as measured by
                  Cockcroft and Gault formula

               -  Aspartate aminotransferase (AST) and ALT ≤2.5 x upper limit of normal (ULN)

               -  Total bilirubin ≤1.5 x ULN, except in subjects with documented Gilbert's
                  Syndrome, who must have a total bilirubin ≤3 x ULN

          6. Women of childbearing potential (WOCBP) must have a negative pregnancy test (serum or
             urine) within the 7 days prior to study drug administration, and within the 3 days
             before the first study drug administration, or a negative pregnancy test within the 24
             hours before the first study drug administration.

          7. WOCBP and male subjects who are sexually active with WOCBP must agree to use 2 highly
             effective methods of contraception (including a physical barrier) before the first
             dose of study drugs, during the study, and for 5 months for women and 7 months for men
             following the last dose of study drug.

          8. Subjects must have the ability to understand and willingness to sign a written
             informed consent document.

        Exclusion Criteria:

          1. Subject must not have received any prior treatment, including chemotherapy, biological
             therapy, or targeted therapy for metastatic pancreatic adenocarcinoma, with the
             following exceptions and notes:

               1. Subjects who have received prior adjuvant therapy for pancreatic adenocarcinoma
                  are eligible if neoadjuvant and adjuvant therapy (including chemotherapy and/or
                  radiotherapy) was fully completed more than 4 months before the start of study
                  treatment. In this case, prior Gem and/or NP is allowable

               2. Prior resection surgery is allowable.

               3. Patients initially diagnosed with locally advanced pancreatic cancer who have
                  undergone chemotherapy then resection and were with no evidence of disease are
                  eligible if metastatic relapse of disease has occurred and if the last dose of
                  chemotherapy was more than 4 months before the data of study entry.

          2. Subjects must not have another active invasive malignancy, with the following
             exceptions and notes:

               1. History of a non-invasive malignancy, such as cervical cancer in situ,
                  non-melanomatous carcinoma of the skin, in situ melanoma, or ductal carcinoma in
                  situ of the breast, is allowed.

               2. History of malignancy that is in complete remission after treatment with curative
                  intent is allowed.

               3. No current or history of a hematologic malignancy is allowed, including subjects
                  who have undergone a bone marrow transplant.

          3. History of clinically significant sensitivity or allergy to monoclonal antibodies,
             their excipients, or intravenous gamma globulin

          4. Previous exposure to CD40, PD-1, PD-L1, CTLA-4 antibodies or any other
             immunomodulatory agent

          5. History of (non-infectious) pneumonitis that required corticosteroids or current
             pneumonitis, or history of interstitial lung disease

          6. Subjects must not have a known or suspected history of an autoimmune disorder,
             including but not limited to inflammatory bowel disease, celiac disease, Wegner
             syndrome, Hashimoto syndrome, systemic lupus erythematosus, scleroderma, sarcoidosis,
             or autoimmune hepatitis, within 3 years of the first dose of investigational agent,
             except for the following.

             a. Subjects with Type 1 diabetes mellitus, hypothyroidism only requiring hormone
             replacement, skin disorders such as vitiligo, or alopecia not requiring systemic
             therapy, or conditions not expected to recur in the absence of an external trigger are
             eligible.

          7. Subjects must not have an uncontrolled intercurrent illness, including an ongoing or
             active infection, current pneumonitis, symptomatic congestive heart failure (New York
             Heart Association class III or IV), unstable angina, uncontrolled hypertension,
             cardiac arrhythmia, interstitial lung disease, active coagulopathy, or uncontrolled
             diabetes.

          8. Subjects must not have a history of myocardial infarction within 6 months or a history
             of arterial thromboembolic event within 3 months of the first dose of investigational
             agent.

          9. Subjects must not have a history of human immunodeficiency virus, hepatitis B, or
             hepatitis C, except for the following:

               1. subjects with anti-hepatitis B core antibody but with undetectable HBV DNA and
                  negative for HBsAg

               2. subjects with resolved or treated HCV (i.e. HCV antibody positive but
                  undetectable HCV RNA)

         10. Subjects must not have a history of primary immunodeficiency.

         11. Subjects must not receive concurrent or prior use of an immunosuppressive agent within
             14 days of the first dose of investigational agent, with the following exceptions and
             notes:

               1. Systemic steroids at physiologic doses (equivalent to dose of oral prednisone 10
                  mg) are permitted. Steroids as anti-emetics for chemotherapy are not allowed.

               2. Intranasal, inhaled, topical, intra-articular, and ocular corticosteroids with
                  minimal systemic absorption are permitted.

               3. Subjects with a condition with anticipated use of systemic steroids above the
                  equivalent of 10 mg prednisone are excluded.

         12. Subjects must not have a history of clinically manifested central nervous system (CNS)
             metastases.

             a. Subjects with known or suspected leptomeningeal disease or cord compression are not
             eligible.

         13. Subjects must not have had major surgery as determined by the PI within 4 weeks before
             the first dose of investigational agent.

         14. Subjects must not have received another investigational agent within the shorter of 4
             weeks or 5 half-lives before the first dose of investigational agent.

         15. Subjects must not have received a live attenuated vaccine within 28 days before the
             first dose of investigational agent, and subjects, if enrolled, should not receive
             live vaccines during the study or for 180 days after the last dose of investigational
             agent.

         16. Females who are pregnant or lactating or who intend to become pregnant during
             participation in the study are not eligible to participate.

         17. Subjects who are of reproductive potential who refuse to use effective methods of
             birth control during the course of participation of the study and within 5 month for
             women and 7 months for men of the last dose of investigational agent are ineligible to
             participate in the study.

         18. Subjects who have any clinically significant psychiatric, social, or medical condition
             that, in the opinion of the investigator, could increase the subject's risk, interfere
             with protocol adherence, or affect the subject's ability to give informed consent are
             ineligible to participate in the study.