Inclusion Criteria:

          -  Diagnosis of advanced/metastatic solid malignancy for which no standard treatment
             option exists that will confer clinical benefit

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

          -  Dose expansion phase only: must have at least one measurable lesion as defined by
             Response Evaluation Criteria in Solid Tumors (RECIST) criteria

          -  Ability to provide written informed consent which must be obtained prior to any
             screening procedures and according to local guidelines

          -  Life expectancy of >= 12 weeks

          -  Absolute neutrophil count >= 1500/mm^3

          -  Platelets >= 100,000/mm^3

          -  Hemoglobin >= 9 g/dL

          -  Potassium >= lower limit of normal (LLN) range for the institution

          -  Calcium >= LLN (corrected for serum albumin, if albumin abnormal)

          -  Magnesium >= LLN

          -  Sodium >= LLN

          -  Phosphorus >= LLN; NOTE: Supplementation may be given before the first dose of study
             medication

          -  International normalized ratio (INR) =< 1.5

          -  Serum creatinine =< 1.5 mg/dL or creatinine clearance >= 50 mL/min (calculated by
             Cockcroft Gault equation)

          -  Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x upper
             limit of normal (ULN) or =< 5 x ULN if liver metastases are present

          -  Total bilirubin =< 3.0 x ULN; if patient has known Gilbert?s syndrome direct bilirubin
             =< 1.5 x ULN

          -  Standard 12-lead electrocardiography (ECG) with the following parameters at screening
             (defined as the mean of the triplicate ECGs):

               -  Fridericia's correction formula (QTcF) interval at screening < 450 msec (using
                  Fridericia? s correction)

               -  Resting heart rate 50 to 100 beats per minute

          -  Negative pregnancy test performed =< 7 days prior to registration (women of
             childbearing potential only)

          -  Able to swallow ribociclib capsules

          -  Willingness to return to enrolling institution for follow-up (during the active
             monitoring phase of the study)

          -  Willingness to provide mandatory blood samples for research purposes

        Exclusion Criteria:

          -  Previous anti-cancer chemotherapy, immunotherapy or investigational agents =< 28 days
             prior to registration

          -  Received radiotherapy =< 28 days or limited field radiation for palliation =< 14 days
             prior to registration, and who has not recovered to grade 1 or better from related
             side effects of such therapy (exceptions include alopecia) and/or in whom >= 25% of
             the bone marrow was irradiated

          -  Major surgery =< 14 days prior to registration or has not recovered from major side
             effects (tumor biopsy is not considered as major surgery)

          -  Active clinically serious infections or other serious uncontrolled medical conditions

          -  Impairment of gastrointestinal (GI) function or GI disease that may significantly
             alter the absorption of the study drugs (e.g., ulcerative diseases, uncontrolled
             nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection)

          -  Baseline neuropathy of > grade 2

          -  Known hypersensitivity to any of the excipients of ribociclib

          -  Known human immunodeficiency virus (HIV) patients with active and untreated disease

          -  Central nervous system (CNS) involvement unless they meet ALL of the following
             criteria:

               -  >= 28 days from prior therapy completion (including radiation and/or surgery) to
                  registration

               -  Clinically stable CNS tumor at the time of screening and not receiving steroids
                  and/or enzyme-inducing anti-epileptic medications for brain metastases

          -  Clinically significant, uncontrolled heart disease and/ or cardiac repolarization
             abnormalities including any of the following:

               -  History of unstable angina pectoris, symptomatic pericarditis, myocardial
                  infarction, coronary artery bypass grafting or coronary angioplasty =< 12 months
                  prior to registration

               -  History of documented congestive heart failure (New York Heart Association
                  functional classification III - IV)

               -  Documented cardiomyopathy

               -  Left ventricular ejection fraction (LVEF) < 50% as determined by echocardiogram
                  (ECHO)

               -  Clinically significant cardiac arrhythmias ( e.g ventricular tachycardia) , left
                  bundle branch block, high-grade atrioventricular (AV) block ( e.g bifascucular
                  block, Mobitz type II and third degree AV block)

               -  Long QT syndrome or family history of idiopathic sudden death or congenital long
                  QT syndrome, or any of the following:

                    -  Risk factors for torsades de pointe (TdP) including uncorrected hypokalemia
                       or hypomagnesemia, history of cardiac failure, or history of clinically
                       significant/symptomatic bradycardia

                    -  Concomitant use of medication(s) with a known risk to prolong the QT
                       interval and/or known to cause torsades de pointe that cannot be
                       discontinued (within 5 half-lives or =< 7 days prior to registration) or
                       replaced by safe alternative medication

                    -  Inability to determine the QT interval on screening (QTcF, using Fridericia?
                       s correction)

          -  Systolic blood pressure > 160 mmHg or < 90 mmHg

          -  Any other concurrent severe and/or uncontrolled medical condition that would, in the
             investigator?s judgment, cause unacceptable safety risks, contraindicate patient
             participation in the clinical study or compromise compliance with the protocol (e.g.,
             chronic pancreatitis, chronic active hepatitis, active untreated or uncontrolled
             fungal, bacterial or viral infections etc.)

          -  Currently receiving any of the following medications and cannot be discontinued 7 days
             prior to starting the study

               -  Herbal supplements including grapefruit, grapefruit hybrids, pummelos,
                  star-fruit, Seville oranges or products containing the juice of each; orange
                  juice is allowed

               -  Known strong inducers or inhibitors of CYP3A4/5 including grapefruit, grapefruit
                  hybrids, pomelos, star-fruit, and Seville oranges

               -  Medications known to have a narrow therapeutic window and are predominantly
                  metabolized through CYP3A4

          -  Currently receiving or has received systemic corticosteroids (=< 14 days prior to
             registration, or who have not fully recovered from side effects of such treatment);
             NOTE: The following uses of corticosteroids are permitted: single doses, topical
             applications (e.g., for rash), inhaled sprays (e.g., for obstructive airways
             diseases), eye drops or local injections (e.g., intra-articular)

          -  History of non-compliance to medical regimen or inability to grant consent

          -  Currently receiving warfarin or other warfarin-derived anticoagulant for treatment,
             prophylaxis or otherwise; Note: Therapy with heparin, direct oral anticoagulants, low
             molecular weight heparin (LMWH) or fondaparinux is allowed

          -  Participation in a prior investigational study =< 30 days prior to enrollment or
             within 5 half-lives of the investigational product, whichever is longer

          -  Failure to recover from all adverse events/toxicities related to prior anticancer
             therapies to grade 1 per National Cancer Institute (NCI)-Common Terminology Criteria
             for Adverse Events (CTCAE) version 4.03; NOTE: Exception: patients with any grade of
             alopecia are allowed to enter the study

          -  Child-Pugh score B or C (for cirrhosis patients only)

          -  Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
             female after conception and until the termination of gestation, confirmed by a
             positive human chorionic gonadotropin (hCG) laboratory test

          -  Women of child-bearing potential, defined as all women physiologically capable of
             becoming pregnant, unless they are using highly effective methods of contraception
             throughout the study and for 8 weeks after study drug discontinuation; highly
             effective contraception methods include:

               -  Total abstinence when this is in line with the preferred and usual lifestyle of
                  the patient; periodic abstinence (e.g., calendar, ovulation, symptothermal,
                  post-ovulation methods) and withdrawal are not acceptable methods of
                  contraception

               -  Female sterilization (have had surgical bilateral oophorectomy with or without
                  hysterectomy), total hysterectomy, or tubal ligation at least 6 weeks before
                  taking study treatment; in case of oophorectomy alone, only when the reproductive
                  status of the woman has been confirmed by follow up hormone level assessment

               -  Male sterilization (at least 6 months prior to screening), the vasectomized male
                  partner should be the sole partner for that patient

               -  Use of oral, injected or implanted hormonal methods of contraception or placement
                  of an intrauterine device (IUD) or intrauterine system (IUS), or other forms of
                  hormonal contraception that have comparable efficacy (failure rate < 1%), for
                  example hormone vaginal ring or transdermal hormone contraception

               -  Note: In case of use of oral contraception, women should have been stable on the
                  same pill for a minimum of 3 months before taking study treatment; Note: Oral
                  contraceptives are allowed but should be used in conjunction with a barrier
                  method of contraception due to unknown effect of drug-drug interaction

               -  Note: Women are considered post-menopausal and not of child bearing potential if
                  they have had 12 months of natural (spontaneous) amenorrhea with an appropriate
                  clinical profile (e.g. age appropriate, history of vasomotor symptoms) is she
                  considered not of child bearing potential

          -  Sexually active males unless they use a condom during intercourse while taking the
             drug and for 21 days after stopping treatment and should not father a child in this
             period; Note: A condom is required to be used also by vasectomized men in order to
             prevent delivery of the drug via seminal fluid

          -  Known standard therapy for the patient?s disease that is potentially curative or
             definitely capable of extending life expectancy