Ipilimumab and Nivolumab Combination Administration
- Ipilimumab 1mg/kg given IV Day 1 for 3 weeks (21 days), for 4 cycles
- Nivolumab 3mg/kg given IV Day 1 for 3 weeks (21 days), for 4 cycles
Nivolumab Alone Administration
- Nivolumab 480mg given IV Day 1 for 4 weeks (28 days), for 5-15 cycles
Nivolumab is to be administered as an approximately 30-minute IV infusion (± 10 minutes). At
the end of the infusion, flush the line with a sufficient quantity of normal saline.
Ipilimumab is to be administered as an approximately 30-minute IV infusion (± 10 minutes). At
the end of the infusion, flush the line with a sufficient quantity of normal saline or 5%
dextrose solution.
When both study drugs are to be administered on the same day, separate infusion bags and
filters must be used for each infusion. Nivolumab is to be administered first. The nivolumab
infusion must be promptly followed by a saline flush to clear the line of nivolumab before
starting the ipilimumab infusion. The second infusion will always be ipilimumab, and will
start at least 30 minutes after completion of the nivolumab infusion.
The dosing calculations should be based on the body weight from Cycle 1 Day 1. If the
subject's weight on the day of dosing differs by > 5% from the weight used to calculate the
dose, the dose should be recalculated based on the current day of treatment weight. All doses
should be rounded to the nearest milligram. There will be no dose modifications allowed.
Inclusion Criteria:
Subject must meet all of the following applicable inclusion criteria to participate in this
study:
- Histological confirmation of melanoma of any mucosal site including (but not limited
to) anus/rectum, vulvar/vaginal, sinonasal. NOTE: Melanomas of cutaneous origin and/or
ocular origin are ineligible.
- R0 or R1 resection of primary melanoma tumor (no gross disease can be left behind, but
microscopically positive margins are acceptable).
- Surgery within ≤ 90 days of registration.
- ECOG Performance Status (PS) ≤ 1
The following laboratory values obtained ≤ 14 days prior to registration:
Hematological:
- Absolute Neutrophil Count (ANC) ≥ 1500/mm^3
- Hemoglobin (Hgb) ≥ 9 g/dL (may be transfused)
- Platelet (Plt) 100,000/mm^3
Renal:
- Serum Creatinine ≤ 1.5 x ULN
Hepatic:
- Alkaline Phosphatase (Alk Phos) ≤ 1.5 x upper limit of normal (ULN)
- Total and Direct Bilirubin ≤ 1.5 × (ULN)
- Aspartate aminotransferase (AST) ≤ 1.5 × ULN
- Negative pregnancy test done ≤ 7 days prior to registration, for women of childbearing
potential only. NOTE: Females are considered of child bearing potential unless they
are surgically sterile (have undergone a hysterectomy, bilateral tubal ligation, or
bilateral oophorectomy) or they are naturally postmenopausal for at least 12
consecutive months.
- Written informed consent and HIPAA authorization for release of personal health
information prior to registration. NOTE: HIPAA authorization may be included in the
informed consent or obtained separately.
- Willing to return to enrolling institution for follow-up
- Willing to provide archival tissue prior to C1D1 if available and blood samples for
correlative research purposes
Exclusion Criteria:
Subjects meeting any of the criteria below may not participate in the study:
- Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment
of the investigator, would make the subject inappropriate for entry into this study or
interfere significantly with the proper assessment of safety and toxicity of the
prescribed regimens.
- Immunocompromised patients and subjects known to be HIV positive and currently
receiving antiretroviral therapy. NOTE: Subjects known to be HIV positive, but without
clinical evidence of an immunocompromised state, are eligible for this trial.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.
- Receiving any other investigational agent which would be considered as a treatment for
the primary neoplasm.
- Other active malignancy ≤ 3 years prior to registration. EXCEPTIONS: Malignancies with
a very low (< 5%) risk of recurrence such as non-melanotic skin cancer or
carcinoma-in-situ of the cervix.
- History of myocardial infarction ≤ 6 months, or congestive heart failure requiring use
of ongoing maintenance therapy for life-threatening ventricular arrhythmias.
- Active autoimmune disease -including but not limited to:
- Subjects with a history of inflammatory bowel disease, including ulcerative
colitis and Crohn's Disease,
- Subjects with a history of symptomatic autoimmune disease requiring systemic
treatment within the past 2 years with the use of disease modifying agents,
corticosteroids, or immunosuppressive drugs.
- rheumatoid arthritis
- systemic progressive sclerosis (scleroderma)
- systemic lupus erythematosus
- psoriasis
- autoimmune vasculitis (e.g., Wegener's Granulomatosis)
- CNS or motor neuropathy considered of autoimmune origin (e.g.,
Guillain-Barre Syndrome and Myasthenia Gravis, multiple sclerosis)
EXCEPTION: autoimmune conditions that are only requiring replacement therapy (e.g.,
thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or
pituitary insufficiency, etc.) is not considered a form of systemic treatment.
- Any radiation within 2 weeks prior to study initiation. Neoadjuvant and adjuvant
radiation are allowed, but must be completed > 2 weeks prior to registration.
- Any prior systemic therapy for melanoma (chemotherapy, immunotherapy, targeted
therapy)
- Women of childbearing potential (WOCBP) must be willing to abstain from heterosexual
intercourse or to use 2 forms of effective methods of contraception from the time of
informed consent until 5 months after the last dose of study drug. The two
contraception methods can be comprised of two barrier methods, or a barrier method
plus a hormonal method. Examples include: intrauterine device (IUD), vasectomy of a
female subject's male partner, contraceptive rod implanted into the skin, or use of
two of the following: diaphragm with spermicide (cannot be used in conjunction with
cervical cap/spermicide), cervical cap with spermicide (nulliparous women only),
contraceptive sponge (nulliparous women only), male condom or female condom (cannot be
used together), hormonal contraceptive.*Abstinence is acceptable if this is the usual
lifestyle and preferred contraception for the subject. NOTE: Male subjects are not
required to utilize contraception. The study regimen is not genotoxic and systemic
concentrations sufficient to produce a risk of fetal toxicity are not expected in
WOCBP partners from exposure to a male participant's seminal fluid.
- Pregnant or breastfeeding (NOTE: breast milk cannot be stored for future use while the
mother is being treated on study).
