Inclusion Criteria:

          -  Be willing and able to provide written informed consent for the trial

          -  Have histologic confirmation of RCC with a clear cell component

          -  Have advanced (not amenable to potentially curative surgery) or metastatic RCC

          -  Available tissue from an archival tissue sample or newly obtained core or excisional
             biopsy of a tumor lesion

          -  May have received previous systemic treatments or regimens for metastatic RCC. Prior
             therapy can include checkpoint blocking antibodies targeting PD-1, PD-L1, or cytotoxic
             T lymphocyte-associated antigen-4 (CTLA-4) and/or targeted agents including TKIs, mTOR
             inhibitors, or bevacizumab. Patients may choose to receive study treatment as their
             initial therapy

          -  Previously treated patients must have documented disease progression after their last
             line of therapy

          -  Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST)
             1.1

          -  Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
             performance scale

          -  Absolute neutrophil count (ANC) >= 1,500 /mcL (within 14 days of treatment initiation)

          -  Platelets >= 100,000/mcL (within 14 days of treatment initiation)

          -  Hemoglobin >= 9 g/dL or >= 5.6 mmol/L (within 14 days of treatment initiation)

          -  Serum creatinine =< 1.5 X upper limit of normal (ULN) OR measured or calculated
             creatinine clearance (glomerular filtration rate [GFR] can also be used in place of
             creatinine or CrCl) >= 40 mL/min for subject with creatinine levels > 1.5 X
             institutional ULN; creatinine clearance should be calculated by Cockcroft-Gault
             (within 14 days of treatment initiation)

          -  Serum total bilirubin =< 1.5 X ULN OR direct bilirubin =< ULN for subjects with total
             bilirubin levels > 1.5 ULN (within 14 days of treatment initiation)

          -  Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and
             alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =< 2.5 X
             ULN OR =< 5 X ULN for subjects with liver metastases (within 14 days of treatment
             initiation)

          -  International normalized ratio (INR) or prothrombin time (PT) =< 1.5 X ULN unless
             subject is receiving anticoagulant therapy as long as PT or partial thromboplastin
             time (PTT) is within therapeutic range of intended use of anticoagulants (within 14
             days of treatment initiation)

          -  Activated partial thromboplastin time (aPTT) =< 1.5 X ULN unless subject is receiving
             anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use
             of anticoagulants (within 14 days of treatment initiation)

          -  Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) >= 65% of
             predicted (dose level 2 and 3)

          -  Left ventricular ejection fraction (LVEF) >= 50% measured by multigated acquisition
             (MUGA) scan, echo, or stress test study with myocardial perfusion imaging

          -  Normal/negative cardiac stress testing with myocardial perfusion imaging OR cardiac
             catheterization with non-significant angiogram findings reviewed by a cardiology
             consultant (dose level 2 and 3)

          -  Female subject of childbearing potential should have a negative urine or serum
             pregnancy test within 72 hours prior to receiving the first dose of study medication;
             if the urine test is positive or cannot be confirmed as negative, a serum pregnancy
             test will be required

          -  Female subjects of childbearing potential should be willing to use 2 methods of birth
             control or be surgically sterile, or abstain from heterosexual activity for the course
             of the study through 120 days after the last dose of study medication; subjects of
             childbearing potential are those who have not been surgically sterilized or have not
             been free from menses for > 1 year

          -  Male subjects should agree to use an adequate method of contraception starting with
             the first dose of study therapy through 120 days after the last dose of study therapy

        Exclusion Criteria:

          -  Has received prior therapy with IL-2 or other investigational systemic cytokine
             therapy signaling through a common γ-chain cytokine receptor including IL-7, IL-15 or
             IL-21

          -  Is currently participating in or has participated in a study of an investigational
             agent or using an investigational device within 4 weeks of the first dose of treatment

          -  Has had a prior monoclonal antibody within 4 weeks prior to study day 1. Has had prior
             chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks
             prior to study day 1

          -  Adverse events due to prior treatment must be resolved to < grade 1

             * Note: If subject received major surgery, they must have recovered adequately from
             the toxicity and/or complications from the intervention prior to starting therapy

          -  For patients previously treated with checkpoint blocking antibodies, no history of
             myocarditis, pneumonitis or nephritis of any grade associated with the prior treatment

          -  Has had autoimmune toxicity associated with prior checkpoint blocking antibodies
             requiring more than one drug class of immune suppressive therapy to resolve (e.g.
             steroid-refractory toxicity requiring infliximab, mycophenolate mofetil, tacrolimus or
             other immune suppressive agent) or requiring continuous immune suppression > 12 weeks,
             or having a severity judged to be life threatening by the investigator

          -  Has a known additional malignancy that is progressing or requires active treatment;
             exceptions include locally curable cancers such as basal cell carcinoma of the skin,
             squamous cell carcinoma of the skin, superficial bladder cancer, or carcinoma in situ
             of the cervix or breast that has undergone potentially curative therapy

          -  Has known active central nervous system (CNS) metastases and/or carcinomatous
             meningitis

               -  (Dose level 1) subjects with previously treated brain metastases may participate
                  provided they are stable (without evidence of progression by imaging for at least
                  four weeks prior to the first dose of trial treatment and any neurologic symptoms
                  have returned to baseline), have no evidence of new or enlarging brain
                  metastases, and are not using steroids for at least 7 days prior to trial
                  treatment

               -  (Dose Level 2 and 3) subjects may not have any history of or current CNS
                  metastases; baseline imaging of the brain is required within 28 days prior to the
                  start of study treatments

          -  Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
             other form of immunosuppressive therapy within 7 days prior to the first dose of trial
             treatment

          -  Has an active autoimmune disease requiring systemic treatment within the past 3 months
             or a documented history of clinically severe autoimmune disease, or a syndrome that
             requires systemic steroids or immunosuppressive agents; subjects with vitiligo or
             resolved childhood asthma/atopy would be an exception to this rule; subjects that
             require intermittent use of bronchodilators or local steroid injections would not be
             excluded from the study; subjects with hypothyroidism stable on hormone replacement or
             Sjorgen's syndrome will not be excluded from the study

          -  Has history of (non-infectious) pneumonitis that required steroids or active,
             non-infectious pneumonitis

          -  Ongoing symptomatic cardiac dysrhythmias, uncontrolled atrial fibrillation, or
             prolongation of the corrected QT interval defined as > 450 msec for males and > 470
             msec for female

          -  History of any of the following cardiovascular conditions within 6 months of
             enrollment: cardiac angioplasty or stenting, myocardial infarction, unstable angina,
             coronary artery bypass graft surgery, class III or IV congestive heart failure as
             defined by the New York Heart Association, symptomatic peripheral vascular disease,
             cerebrovascular accident, or transient ischemic attack

          -  Has an active infection requiring systemic therapy

          -  Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the trial, interfere with the subject's
             participation for the full duration of the trial, or is not in the best interest of
             the subject to participate, in the opinion of the treating investigator

          -  Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial

          -  Is pregnant or breastfeeding, or expecting to conceive or father children within the
             projected duration of the trial, starting with the pre-screening or screening visit
             through 120 days after the last dose of trial treatment

          -  Has a known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies)

          -  Has known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or
             hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [RNA] [qualitative] is
             detected)

          -  Has received a live vaccine within 30 days prior to the first dose of trial treatment;
             Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines
             and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live
             attenuated vaccines, and are not allowed