Clinical Trials /

Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant

NCT03267186

Description:

This phase II trial studies how well ibrutinib works in preventing acute leukemia in patients after reduced-intensity conditioning and stem cell transplant. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Related Conditions:
  • Acute Biphenotypic Leukemia
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Chronic Myeloid Leukemia
Recruiting Status:

Recruiting

Phase:

Phase 2

Trial Eligibility

Document

Title

  • Brief Title: Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant
  • Official Title: A Phase 2 Study of Ibrutinib Maintenance After Reduced-Intensity Conditioning and Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia

Clinical Trial IDs

  • ORG STUDY ID: IRB-38934
  • SECONDARY ID: NCI-2017-00125
  • SECONDARY ID: IRB-38934
  • SECONDARY ID: BMT302
  • NCT ID: NCT03267186

Conditions

  • Acute Biphenotypic Leukemia
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Chronic Myelogenous Leukemia, BCR-ABL1 Positive
  • Hematopoietic Cell Transplantation Recipient

Interventions

DrugSynonymsArms
IbrutinibBTK Inhibitor PCI-32765, CRA-032765, Imbruvica, PCI-32765Prevention (ibrutinib)

Purpose

This phase II trial studies how well ibrutinib works in preventing acute leukemia in patients after reduced-intensity conditioning and stem cell transplant. Ibrutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed Description

      PRIMARY OBJECTIVES:

      I. To reduce the incidence of relapse at 18 months after reduced-intensity conditioning (RIC)
      and allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML),
      acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML) in blast crisis from a
      historical baseline of 45% to 25%, using ibrutinib maintenance therapy.

      SECONDARY OBJECTIVES:

      I. To study the incidence and severity of post-transplant complications in subjects receiving
      ibrutinib maintenance after allogeneic HCT.

      II. To study the incidence of infectious complications in subjects receiving maintenance
      ibrutinib after allogeneic HCT.

      III. To study the impact of ibrutinib maintenance on minimal residual disease after RIC and
      allogeneic HCT.

      IV. To study the impact of maintenance ibrutinib on immune reconstitution and alloreactivity
      after allogeneic HCT, specifically on Th1/ Th2 polarization, T follicular cell number, T and
      B cell repertoire, serum immunoglobulin levels, and alloantibody formation.

      OUTLINE:

      Beginning 60-90 days after allogeneic HCT, patients receive ibrutinib orally (PO) once daily
      (QD) for up to 18 months post-transplant in the absence of disease progression or
      unacceptable toxicity.

      After completion of study treatment, patients are followed up for 2 years.
    

Trial Arms

NameTypeDescriptionInterventions
Prevention (ibrutinib)ExperimentalBeginning 60-90 days after allogeneic HCT, patients receive ibrutinib PO QD for up to 18 months post-transplant in the absence of disease progression or unacceptable toxicity.
  • Ibrutinib

Eligibility Criteria

        Inclusion Criteria:

          -  INCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT)

          -  Diagnosis of acute myeloid leukemia (AML), acute biphenotypic leukemia, or acute
             lymphoblastic leukemia (ALL); CML transformed to blast crisis is eligible

          -  Planned allogeneic HCT using fludarabine phosphate (FLU)/melphalan hydrochloride (MEL)
             or FLU/busulfan (BU) conditioning

          -  Planned graft versus host disease (GVHD) prophylaxis consisting of tacrolimus
             (TAC)/methotrexate (MTX) or TAC/sirolimus (SRL)

          -  Human leukocyte antigen (HLA) identical sibling donor, HLA matched unrelated donor, or
             donor mismatched at 1 HLA allele or antigen

          -  Less than or equal to 5% blasts on bone marrow examination within 60 days of starting
             conditioning

          -  Age >= 18 years and =< 70 years

          -  Able to give informed consent

          -  Subjects will be eligible if their planned conditioning regimen for allogeneic HCT
             consists of one of the two following standard reduced intensity conditioning regimens:

               -  FLU/MEL: fludarabine phosphate (fludarabine) 120 to 180 mg/m^2; melphalan
                  hydrochloride (melphalan) =< 150 mg/m^2

               -  FLU/BU: fludarabine 120 to 180 mg/m^2; busulfan =< 8 mg/kg orally or =< 6.4 mg/kg
                  intravenously

          -  Subjects will be eligible if their planned post grafting immunosuppression consists of
             one of the two following regimens:

               -  TAC/MTX: tacrolimus (oral or intravenous) and intravenous methotrexate
                  administered according to institutional standard practice.

               -  TAC/SRL: tacrolimus (oral or intravenous) and oral sirolimus, administered
                  according to institutional standards of care

          -  INCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION)

          -  Age >= 18 years

          -  Eastern Cooperative Oncology Group (ECOG) performance status of =< 2

          -  Absolute neutrophil count (ANC) > 0.75 x 10^9/L

          -  Platelet count > 50 x 10^9/L

          -  Hemoglobin > 8.0 g/dL without transfusion or growth factor support for at least 7 days
             prior to screening (with the exception of pegylated granulocyte-colony stimulating
             factor [G-CSF] and darbopoietin, which require at least 14 days of abstinence prior to
             screening)

          -  Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x
             upper limit of normal

          -  Estimated creatinine clearance >= 30 mL/min via Cockroft-Gault formula

          -  Bilirubin =< 1.5 x upper limit of normal (unless elevated bilirubin is due to
             Gilbert's syndrome or of non-hepatic origin)

          -  Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin
             time (PTT) (activated partial thromboplastin time [aPTT]) =< 1.5 x upper limit of
             normal

          -  Female subjects who are of non-reproductive potential (ie, post-menopausal by history
             - no menses for >= 1 year; OR history of hysterectomy; OR history of bilateral tubal
             ligation; OR history of bilateral oophorectomy); female subjects of childbearing
             potential must have a negative serum pregnancy test upon screening

          -  Male and female subjects who agree to use both a highly effective method of birth
             control (eg, implants, injectables, combined oral contraceptives, some intrauterine
             devices [IUDs], sexual abstinence, or sterilized partner) and a barrier method (eg,
             condoms, vaginal ring, sponge, etc) during the period of therapy and for 30 days after
             the last dose of study drug for females and 90 days after the last dose of the study
             drug for males

          -  Between day +60 and day +90 after allogeneic HCT

        Exclusion Criteria:

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Active involvement of the central
             nervous system with malignancy (previous central nervous system [CNS] involvement is
             allowed if clearance of CNS disease has been documented prior to enrollment)

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Pregnant or breastfeeding

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Karnofsky performance status < 60%

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Active leukemia (> 5% leukemic
             blasts in peripheral blood or bone marrow)

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Non-hematologic malignancy with a
             life expectancy of < 5 years

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Known history of human
             immunodeficiency virus (HIV) or active hepatitis C virus (HCV) or hepatitis B virus
             (HBV) infection; subjects who are positive for hepatitis B core antibody or hepatitis
             B surface antigen must have a negative polymerase chain reaction (PCR) result before
             enrollment; those who are PCR positive will be excluded

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): Known bleeding disorders (eg, von
             Willebrand's disease) or hemophilia

          -  EXCLUSION CRITERIA FOR ENROLLMENT (PRE-TRANSPLANT): History of other malignancies,
             except:

               -  Malignancy treated with curative intent and with no known active disease present
                  for >= 3 years before the first dose of study drug and felt to be at low risk for
                  recurrence by treating physician

               -  Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
                  of disease Adequately treated carcinoma in situ without evidence of disease

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Active and uncontrolled acute
             GVHD grades III or IV

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Use of secondary therapy for
             acute GVHD at any time (defined as any systemic therapy intended to treat acute GVHD
             besides corticosteroids)

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Requirement for
             anticoagulation with warfarin or other vitamin K antagonists (concomitant use of other
             anticoagulants is permitted)

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Relapsed leukemia (> 5%
             leukemic blasts in peripheral blood or bone marrow after allogeneic HCT)

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Karnofsky performance status <
             60%

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Chemotherapy =< 21 days prior
             to first administration of study treatment and/or monoclonal antibody =< 6 weeks prior
             to first administration of study treatment

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Vaccinated with live,
             attenuated vaccines within 4 weeks of first dose of study drug

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Currently active, clinically
             significant cardiovascular disease, such as uncontrolled arrhythmia or class 3 or 4
             congestive heart failure as defined by the New York Heart Association Functional
             Classification; or a history of myocardial infarction, unstable angina, or acute
             coronary syndrome within 6 months prior to randomization

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): History of stroke or
             intracranial hemorrhage within 6 months prior to screening

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Any life threatening illness,
             medical condition, or organ system dysfunction that, in the investigator's opinion,
             could compromise the subject's safety or put the study outcomes at undue risk

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Major surgery within 4 weeks
             of first dose of study drug

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Any uncontrolled active
             systemic infection

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Unresolved toxicities from
             prior anti cancer therapy, defined as having not resolved to Common Terminology
             Criteria for Adverse Event (CTCAE, version 4), grade =< 1, or to the levels dictated
             in the inclusion/exclusion criteria with the exception of alopecia

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Unable to swallow capsules or
             malabsorption syndrome, disease significantly affecting gastrointestinal function, or
             resection of the stomach or small bowel, symptomatic inflammatory bowel disease or
             ulcerative colitis, or partial or complete bowel obstruction

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Requires treatment with a
             strong cytochrome P450 (CYP) 3A4/5 inhibitor

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Unwilling or unable to
             participate in all required study evaluations and procedures

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Unable to understand the
             purpose and risks of the study and to provide a signed and dated informed consent form
             (ICF) and authorization to use protected health information (in accordance with
             national and local subject privacy regulations)

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Currently active, clinically
             significant hepatic impairment (Child-Pugh class B or C)

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Lactating or pregnant

          -  EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Uncontrolled cardiac
             arrhythmias
      
Maximum Eligible Age:70 Years
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Incidence of relapsed leukemia
Time Frame:Up to 18 months
Safety Issue:
Description:Incidence of relapsed leukemia defined as > 5% leukemic blasts detected in bone marrow or peripheral blood. Participants will also be considered to have relapsed leukemia if they receive any active treatment for progressive leukemia after allogeneic HCT, even if they have < 5% leukemic blasts. Withdrawal of immunosuppression alone is not considered an active treatment for progressive disease.

Secondary Outcome Measures

Measure:Incidence of acute GVHD grades II-IV and III-IV
Time Frame:At 180 days
Safety Issue:
Description:Incidence of acute GVHD grades II-IV and III-IV will be evaluated according following criteria. Stage of Acute GvHD was assessed as follows. Stage 1: Skin: rash < 25% of skin. Liver: bilirubin 2 to 3 mg/dL. Gut: diarrhea >500 mL/day or upper-gut symptoms with positive histology Stage 2: Skin: rash 25 to 50% of skin. Liver: bilirubin 3 to 6 mg/dL. Gut: diarrhea >1000 mL/day. Stage 3: Skin: rash > 50% of skin. Liver: bilirubin 6 to 15 mg/dL. Gut: diarrhea > 1500 mL/day. Stage 4: Skin: generalized erythroderma with bulla formation. Liver: bilirubin > 15 mg/dL. Gut: diarrhea > 2500 mL/day or severe abdominal pain with or without ileus Grade of Acute GvHD was determined as follows. Grade 1: Stage 1-2 Skin + No Liver stage + No Gut stage Grade 2: Stage 3 Skin OR Stage 1 Liver or Stage 1 Gut Grade 3: No Skin stage + Stage 2 to 3 Liver Stage 2 to 4 Gut Grade 4: Stage 4 Skin + or Stage 2 to 3 Liver + No Gut stage
Measure:Incidence of chronic GVHD
Time Frame:At 18 months
Safety Issue:
Description:Assessment of chronic GvHD will be performed using the 2015 NIH consensus criteria
Measure:Incidence of detectable minimal residual disease
Time Frame:At 1 year
Safety Issue:
Description:Incidence of detectable minimal residual disease will be assessed using high-throughput sequencing (ClonoSEQ) and high-sensitivity flow cytometry. Minimal residual disease will be considered present if > 1 x 10^-6 leukemic clones are detected by ClonoSEQ, or if any aberrant blasts matching the original leukemic immunophenotype are detected by high-sensitivity flow cytometry.

Details

Phase:Phase 2
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:Andrew Rezvani

Last Updated

November 4, 2019