Inclusion Criteria:

          1. Volunteered for attending the study, and signed informed consent form (ICF)to
             participate in the study.

          2. Cytologically and Histologically documented, locally advanced or recurrent or
             metastatic (stage IIIb, IIIc, IV) non-small cell lung cancer patients .

          3. EGFR mutation (exon 19 deletion or exon 21 L858R) with Bim deletion or low abundance
             for EGFR mutation.

          4. Age range: 18 years to 75 years.

          5. Patients must have measurable lesion according to the RECIST (version 1.1) criteria.

          6. Life expectancy of ≥ 12 weeks

          7. ECOG (Eastern Cooperative Oncology Group) performance status of ≤ 1.

          8. Patients hadn't received past system treatment, including cytotoxic drugs; For
             patients who have received adjuvant or neoadjuvant chemotherapy appears recurrence or
             metastasis more than 6 months from accepting the last dose of chemotherapy drugs

          9. Adequate organ function as defined by the following criteria:

               -  Bone marrow function: absolute neutrophil count ≥ 1,500,000,000/L and platelet
                  count ≥100,000,000,000/L and hemoglobin ≥9g/dL.

               -  Liver function: Total bilirubin ≤ 1.5 ULN (upper limit of normal). AP (alkaline
                  phosphatase), AST ( aspartate aminotransferase) and ALT (alanine transaminase) ≤
                  3 ULN in the absence of liver metastases or up to 5 ULN in case of liver
                  metastases.

               -  Renal function: creatinine clearance ≥ 60 ml/min. (based on modified
                  Cockcroft-Gault formula).

               -  INR （international normalized ratio）≤ 1.5, and partial thromboplastin time (PTT)
                  or activated partial thromboplastin time (aPTT) ≤ 1.5 ULN.

         10. For all females of childbearing potential a negative serum/urine pregnancy test must
             be obtained within 48 hours before enrollment. Postmenopausal women must have been
             amenorrhoeic for at least 12 months to be considered of non-childbearing potential.

         11. Fertile men and women must use effective contraception.

        Exclusion Criteria:

          1. Histology confirmed for squamous carcinomas, including mixed gland scale cancer, small
             cell lung cancer.

          2. Poor controlled hypertension, it means systolic pressure ≥140 mmHg and/or diastolic
             pressure ≥90 mmHg after drug therapy.

          3. There are imaging evidence of tumor invading or closing to the pulmonary vessels
             (e.g., pulmonary artery, superior vena cava).

          4. Thrombosis in 6 months before enrollment, including pulmonary thrombosis or deep
             venous thrombosis., or patient had medical evidence or history of thrombosis or
             bleeding tendency regardless of the severity.

          5. Patients with medical history of hemoptysis (defined as about 2.5ml bright blood) 2
             weeks before the enrollments.

          6. Proteinuria ≥++, or 24h proteinuria ≥1.0g.

          7. A uncontrolled clinical infection, activity, including but not limited to acute
             pneumonia.

          8. Patients with known liver disease: the hepatitis B virus (HBV) infection and hepatitis
             b virus DNA (HBV DNA) ≥ 500 copy number or ≥100 IU/ml; or more; or hepatitis C virus
             (HCV) infection; or liver cirrhosis, etc.

          9. Patients who are at risk of human immunodeficiency virus (HIV) or syphilis infection.

         10. Patients who have a difficulty in swallowing or drug absorption.

         11. There are diseases of alimentary canal such as active duodenal ulcer, the ulcerous
             colitis, intestinal obstruction or other conditions which can cause gastrointestinal
             bleeding or perforation in the investigator's opinion; or patient has a history of
             intestinal perforation, intestinal fistula.

         12. Evaluation of cardiac function: left ventricular ejection fraction < 50%
             (echocardiography); Moderate or above disorders of mitral valve and tricuspid shut
             down;, serious/unstable angina or acute myocardial infarction coronary artery bypass
             surgery in 6 months before enrollment; patients with class 2 and above cardiac
             dysfunction according to New York heart association (NYHA) classification

         13. Stroke and transient ischemic in 12 months before enrollment.

         14. severe ulcer in the skin wound, trauma and mucosa or fractures have been not fully
             healed.

         15. Patients received CYP3A4 strong inhibitor and/or inducer in 2 weeks before enrollment;
             Patients received P-gp and breast cancer resistance protein (BCRP) substrates drug in
             2 weeks before enrollment.

         16. Patients received other anti-tumor treatment at the same time.

         17. Patients exist serious psychological or mental abnormalities, so patient compliance is
             not sufficient.

         18. Poorly controlled serous cavity effusion, including but not limited to malignant
             pleural effusion, malignant pericardial effusion and malignant peritoneal effusion.

         19. Patients have a weight loss (≥10%) within 6 weeks before enrollment.

         20. The pregnancy of female patients test is positive or lactation women.

         21. Patients haven't been diagnosed other malignant disease, except the basal cell
             carcinoma and cervical carcinoma.