Inclusion criteria

          1. Eligible diagnoses are listed below:

             AML with adverse risk genetic abnormalities (according to the ELN guidelines)1. AML
             with intermediate genetic abnormalities (according to ELN guidelines) either in first
             complete remission, after relapse, or by chemotherapy-refractory disease.

             AML with favourable genetic abnormalities (according to ELN guidelines) after relapse
             or by chemotherapy-refractory disease, except APL.

             AML with undefined genetic risk classification after relapse or with
             chemotherapy-refractory disease.

             AML arising from myelodysplastic syndrome (MDS) or a myeloproliferative neoplasia,
             except if favourable genetic abnormalities (according to ELN guidelines) are present.

             Therapy-related myeloid neoplasia except if favorable genetic abnormalities (according
             to ELN guidelines) are present.

             MDS with high risk or very high risk disease (according to the IPSS-R score)2.

             First CR of high-risk ALL, defined by one or more of these:

               -  Early or mature T-ALL (CD1a negative).

               -  Pro B-ALL with t(4v;11); KMT2A-rearrangements.

               -  Presence of BCR-ABL and/or t(9;22).

               -  Persistence of minimal residual disease after the second induction course. ALL
                  with or without complete remission after salvage therapy following poor response
                  to induction therapy.

             ALL after haematological or molecular relapse.

          2. Fit for transplant according to physician judgement.

          3. No history of cardiac disease and absence of active symptoms, otherwise, documented
             left ventricular ejection fraction ≥40%.

          4. No history of chronic pulmonary disease and absence of dyspnea. Otherwise, documented
             diffusion lung capacity for carbon monoxide (DLCO) ≥40% or FEV1/FVC ≥ 50% despite
             appropriate treatment

          5. Availability of ≥1 unrelated donor with a single allele or antigen mismatch at HLA-A,
             -B, -C, or -DRB1 and no concurrent DQB1 mismatch (9/10) shown by confirmatory typing.

          6. Availability of at least one haploidentical donor meeting the following criteria:

        Donor is a biologic parent / child of the patient, or haploidentity has been confirmed for
        patient's relatives by HLA-Typing.

        The donor has expressed his/her will to donate and has no contraindications against a stem
        cell donation by medical history.

        Donor age is ≥18 years and ≤75 years.

        Exclusion criteria

          1. Relapse or graft failure after a first allogeneic transplantation.

          2. Thymic ALL in first complete remission.

          3. Severe organ dysfunction defined by either of the following three criteria:

             Patients who receive supplementary continuous oxygen. Serum bilirubin >1.5 x ULN (if
             not considered Gilbert-Syndrome) or ASAT/ALAT >5 x ULN.

             Estimated Glomerular Filtration Rate (GFR) < 40 mL/min

          4. Uncontrolled infection at the time of enrollment.

          5. Pregnant or breast-feeding women.

          6. An HLA-identical sibling donor or 8/8 (HLA-A, -B, -C, or -DRB1) matched unrelated
             donor is available and suitable to donate prior to randomization.

          7. Men unable or unwilling to use adequate contraception methods from enrollment to
             minimum of six months after the last dose of chemotherapy.

          8. Women of childbearing potential except those who fulfill the following criteria:
             Post-menopausal or post-operative or continuous and correct application of a
             contraception method with a Pearl Index <1% or sexual abstinence or vasectomy of the
             sexual partner.

          9. Simultaneous participation in another clinical trial.