Inclusion criteria:

          -  Participants must be postmenopausal women

          -  Histological diagnosis of breast adenocarcinoma

          -  Locally advanced or metastatic disease

          -  Either primary tumor or any metastatic site to be positive for Estrogen Receptors
             (ER+) and negative for HER2 (HER2-) receptor

          -  Participants previously treated with endocrine therapy for advanced disease: at least
             6 months exposure to endocrine therapy (Participants with early relapse while on
             adjuvant endocrine therapy that was initiated ≥24 months ago, or who relapsed < 12
             months after completion of adjuvant endocrine therapy are eligible); in Arm #2 Part D,
             no more than 2 prior lines of endocrine therapy are allowed; in Arm #3 Parts F and G,
             participants must have received and progressed on Aromatase Inhibitor (AI) in
             combination with CDK4/6 Inhibitor as the first line (1L) treatment for advanced
             disease prior to receiving the study treatment, and not followed by additional
             endocrine therapy for advanced disease before entering the study; for Arm #4 (Parts H
             and I) and Arm #5 (J and K): no more than 1 prior line of a single endocrine therapy
             for advanced disease is allowed or for Arm #4 Parts H and I: participants must have
             received and progressed on a non-steroidal Aromatase Inhibitor (AI) in combination
             with a CDK4/6 Inhibitor as the first line (1L) treatment for advanced disease prior to
             receiving the study treatment; For Arms #2, #3,#4, and #5 (Parts C, D, F, G, H, I, J
             and K) participants who relapsed while on adjuvant endocrine therapy that was
             initiated ≥24 months ago, or relapsed < 12 months after completion of adjuvant
             endocrine therapy are eligible.

          -  Participants previously treated with chemotherapy for advanced disease: no more than 3
             prior chemotherapeutic regimens in Arm #1 Part A, and no more than 1 prior
             chemotherapeutic regimen in Arms #1, #2, #3, #4, and #5 (Parts B, C, D, F, H and J
             respectively); prior chemotherapy for advanced disease is not allowed in dose
             expansion of Arms #3, #4, and #5 (Part G, I and K respectively).

          -  Measurable lesion

        Exclusion criteria:

          -  Medical history or ongoing gastrointestinal disorders that could affect absorption of
             oral study drugs (including difficulties with swallowing capsules)

          -  Participants with any other cancer (except for adequately treated basal cell or
             squamous cell skin cancer, in situ cervical cancer or any other cancer from which the
             participant has been disease free for >3 years)

          -  Participants with known brain metastases

          -  Treatment with anticancer agents (including investigational drugs) less than 2 weeks
             before first study treatment starts (less than 4 weeks if the anticancer agents were
             antibodies)

          -  Prior treatment with another selective ER down-regulator (SERD), except fulvestrant
             with a washout of at least 6 weeks prior to the first study drug administration. In
             Arms #3, #4, and #5 (Parts F, G, H, I, J and K): prior (last) treatment with any SERD
             including fulvestrant will not be allowed.

          -  Inadequate hematological and biochemical lab tests

          -  Participants with Gilbert disease

          -  Treatment with HIV-antiviral, antifungal and antioxidant agents less than 2 weeks
             before study treatment starts

          -  Treatment with strong and moderate cytochrome P450 (CYP) 3A or CYP2C8 inducers within
             2 weeks before first study treatment

          -  Treatment with strong CYP3A inhibitors within 2 weeks before first study treatment
             starts

          -  More than one prior advanced cyclin-dependent kinase (CDK) 4/6 inhibitor based therapy
             in Arm #1 (Parts A and B), Arm #2 (Part C), and Arm #3 (Parts F and G)

          -  Arm #2, #3, #4 and #5 (Parts C, D, F, G, H, I, J and K) only: participants with
             concurrent or history of pneumonitis

          -  Arm #3, #4 and #5 (Parts F, G, H, I, J and K) only: prior treatment therapies that
             target the PI3K axis (mTOR inhibitors, AKT inhibitors, PI3K inhibitors)

          -  Arm #3 and #4 (Parts F, G, H and I) only: participants with diabetes mellitus type-I
             or uncontrolled diabetes mellitus type-II: ie, fasting plasma glucose ≥ 140mg/dl (7.7
             mmol/l) or HbA1C > 6.2%

          -  Arm #3 and #4 (Parts F, G, H and I) only: history of severe cutaneous reaction (eg.
             Stevens-Johnson syndrome [SJS], erythema multiforme [EM]), toxic epidermal necrolysis
             (TEN), and drug reaction with eosinophilia and systemic symptoms [DRESS].

          -  Arm #3 (Parts F and G) only: ongoing osteonecrosis of jaw

          -  Arm #4 (Parts H and I) only: any active, untreated or uncontrolled infection (e.g.
             viral, bacterial, fungal etc.)

          -  Arm #4 (Parts H and I) only: participants with active and uncontrolled stomatitis,
             angioedema due to concomitant treatment with ACE inhibitors, impaired wounds

          -  Arm #4 (Parts H and I) only: uncontrolled hypercholesterolemia, hypertriglyceridemia
             and hyperglycemia in non-diabetic participants

          -  Arm #4 (Parts H and I) only: treatment with strong or moderate CYP3A4 inhibitors,
             strong CYP3A4 inducers and/or P-gp inhibitors within 2 weeks before the first study
             treatment administration or 5 elimination half-lives, whichever is the longest

          -  Arm #5 (Parts J and K) only: history or current (controlled/not) venous
             thromboembolism (i.e. deep vein thrombosis (DVT), pulmonary embolism (PE), cerebral
             venous sinus thrombosis (CVST)

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.