Inclusion Criteria:

          1. Subject is ≥ 18 years of age at the time of signing the informed consent form ().

          2. Subject must understand and voluntarily sign an ICF prior to any study-related
             assessments/procedures being conducted.

          3. Subject is willing and able to adhere to the study visit schedule and other protocol
             requirements.

          4. Subject must have histologically confirmed at last relapse aggressive B-cell NHL
             according to "The 2016 revision of the WHO classification of lymphoid neoplasms"
             defined as:

               1. Diffuse large B-cell lymphoma (DLBCL) Not otherwise specified (NOS) including
                  transformed indolent Non-Hodgkin lymphoma (NHL)

               2. Follicular lymphoma Grade 3B

               3. T cell/histiocyte-rich large B-cell lymphoma

               4. Epstein-Barr virus (EBV) positive DLBCL, NOS

               5. Primary mediastinal (thymic) large B-cell lymphoma

               6. High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with
                  DLBCL histology (double/triple-hit lymphoma)

          5. Subjects disease must have relapsed or be refractory to at least 2 prior lines of
             therapy. Previous therapy must have included a CD20-targeted agent and an
             anthracycline.

          6. Subject must have

               1. Positron emission tomography (PET)-positive (Deauville score 4 or 5) and computed
                  tomography (CT) measurable disease as per Lugano Classification

               2. Sum of product of perpendicular diameters (SPD) of up to 6 index lesions ≥ 25 cm2
                  by CT scan (not applicable to Arm A or B or subjects with Richter's
                  transformation)

          7. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1 at screening

          8. Adequate organ function

          9. Subjects must agree to not donate blood, organs, sperm or semen, and egg cells for
             usage in other individuals

         10. Participants must agree to use effective contraception

        Exclusion Criteria:

          1. Subject has any significant medical condition, laboratory abnormality, or psychiatric
             illness that would prevent the subject from participating in the study based on
             investigator´s judgment.

          2. Subject has any condition including the presence of laboratory abnormalities, which
             places the subject at unacceptable risk if he/she were to participate in the study
             based on investigator´s judgment.

          3. Subject has any condition that confounds the ability to interpret data from the study
             based on investigator´s judgment.

          4. Subjects with prior history of malignancies, other than aggressive R/R NHL, unless the
             subject has been free of the disease for ≥ 2 years with the exception of the following
             non-invasive malignancies:

               1. Basal cell carcinoma of the skin

               2. Squamous cell carcinoma of the skin

               3. Carcinoma in situ of the cervix

               4. Carcinoma in situ of the breast

               5. Incidental histologic finding of prostate cancer (T1a or T1b using the TNM
                  [tumor, nodes, metastasis] clinical staging system) or prostate cancer that is
                  curative.

               6. Other completely resected stage 1 solid tumor with low risk for recurrence

          5. Prior treatment with any prior gene therap y product

          6. Prior treatment with any adoptive T cell therapy; prior hematopoietic stem cell
             transplant (HSCT) is allowed

          7. Allogeneic HSCT within 90 days of leukapheresis

          8. Prior treatment with the combination agent from the assigned arm:

               1. Anti PD-1 or PD-L1 (Arm A and E)

               2. CC-122 (Arm B)

               3. CC-220 (Arm C)

               4. Prior treatment with ibrutinib is not exclusionary for subjects on any study arm

               5. Anti LAG-3 targeted agent (Arm E)

               6. CC-99282 (Arm F)

          9. Presence of acute or chronic graft-versus-host disease (GVHD)

         10. History of or active hepatitis B or hepatitis C or human immunodeficiency virus (HIV)
             infection

         11. Uncontrolled bacterial, viral or fungal infection at the time of leukapheresis,
             lymphodepleting chemotherapy or JCAR017 infusion

         12. Any history of myocarditis (Arm E); history of any one of the following cardiovascular
             conditions within the past 6 months: Class III or IV heart failure as defined by the
             New York Heart Association (NYHA), cardiac angioplasty or stenting, myocardial
             infarction, unstable angina, or other clinically significant cardiac disease (all
             arms)

         13. History or presence of clinically relevant central nervous system (CNS) pathology such
             as epilepsy, seizure, paresis, aphasia, stroke, severe brain injuries, dementia,
             Parkinson's disease, cerebellar disease, organic brain syndrome, or psychosis

         14. Subjects with active CNS or cerebrospinal fluid (CSF) involvement by malignancy

         15. Pregnant or nursing (lactating) women.

         16. Subjects with active auto immune disorders/processes or active neurological or
             inflammatory disorders

         17. For subjects to receive oral combination therapy (Arms B, C, D or F): History of a
             gastrointestinal (GI) condition or procedure that in the opinion of the investigator
             may affect oral drug absorption.

         18. Progressive tumor invasion of venous or arterial vessels.

         19. Deep venous thrombosis (DVT)/pulmonary embolism (PE) not managed on a stable regimen
             of anticoagulation.