Inclusion Criteria:

          1. Male or female ≥ 18 years of age

          2. Diagnosis of advanced solid tumor or hematologic malignancy (limited to lymphoma) that
             has failed or become intolerant to standard therapy (Component 1 - single agent PAC-1)
             Note: Gliomas are excluded from Component 1 (see exclusion #19)

          3. Diagnosis of high grade glioma: glioblastoma multiforme (GBM) or anaplastic
             astrocytoma after progression following treatment with standard first line therapy
             (Component 2 - PAC-1 in combination with temozolomide).

          4. Has measurable disease, defined as at least 1 tumor that fulfills the criteria for a
             target lesion according to RECIST 1.1 (Component 1).

          5. For patients in study Component 2 measurable disease RANO criteria will be used.

          6. Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 (see
             Appendix 4)

          7. Has adequate hepatic function defined as total bilirubin < 1.5 mg/dL, serum albumin >
             3.0 gm/dL, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 1.5 ×
             upper limit of normal (ULN) or < 3 x ULN for subjects with known hepatic metastases

          8. Has adequate renal function defined as serum creatinine < 1.5 × ULN

          9. Has adequate bone marrow function defined as a hemoglobin ≥ 10 g/dL, absolute
             neutrophil count (ANC) ≥ 1.5 × 109/L, and platelet count ≥ 100 × 109/L

         10. Patients taking antiepileptic drugs (AED) must be on stable doses of AED for at least
             two weeks prior to registration and have no episode of seizures for at least 14 days
             prior to registration. Because some AEDs enhance or inhibit enzymes that may affect
             PAC-1 metabolism, those AEDs will not be permitted in this study. The AEDs that are
             and are not permissible are in Appendix 6.

         11. Patient must be able to take oral medication and to maintain a fast as required for 2
             hours before and 1 hour after capsule(s) administration

         12. Must be willing and able to comply with study visits and procedures

         13. Has read, understood and signed the informed consent form (ICF) approved by the
             Institutional Review Board/Independent Ethics Committee (IRB/IEC)

         14. Women of childbearing potential (WOCP) must not be pregnant (confirmed by a negative
             pregnancy test, with a serum B-HCG with a sensitivity of 50 mL U/L within 7 days of
             study treatment) or breast-feeding. In addition, a medically acceptable method of
             birth control must be used such as an oral, implantable, injectable, or transdermal
             hormonal contraceptive, an intrauterine device (IUD), use of a double barrier method
             (condoms, sponge, diaphragm, or vaginal ring with spermicidal jellies or cream), or
             total abstinence during the study participation and for one month after last dose of
             study drug(s). Women who are postmenopausal for at least 1 year or surgically sterile
             (bilateral tubal ligation, bilateral oophorectomy, or hysterectomy) are not considered
             to be WOCP.

         15. Men who are not surgically or medically sterile must agree to use an acceptable method
             of contraception. Male patients with female sexual partners who are pregnant, possibly
             pregnant, or who could become pregnant during the study must agree to use condoms at
             least one month after the last dose of study drug. Total abstinence for the same study
             period is an acceptable alternative.

         16. Prior systemic treatments for metastatic disease are permitted but may not be ongoing,
             including targeted therapies, biologic response modifiers, chemotherapy, hormonal
             therapy, or investigational therapy (see Exclusion #20).

         17. Willingness to donate blood for biomarker studies related to the type of therapies
             used in this trial and the tumor types being treated

             Exclusion Criteria:

         18. Had surgery within 4 weeks prior to study treatment except for minor procedures
             (hepatic biliary stent placement is allowed)

         19. For Component 1 (PAC-1 alone), gliomas are excluded, as well as any history of brain
             metastases, seizures or underlying brain injury (e.g., traumatic brain injury, or
             hemorrhagic or ischemic stroke)

         20. Patients may not have received cytotoxic chemotherapy, targeted therapies, biologic
             response modifiers, chemotherapy, and hormonal therapy within the last 3 weeks, or
             nitrosureas within the last 6 weeks prior to study treatment.

         21. Has a known hypersensitivity to temozolomide (this criterion applies only in Component
             2)

         22. Has a history of blood clots, pulmonary embolism, or deep vein thrombosis unless
             controlled by anticoagulant treatment (patient must be on stable dose for 2 weeks)

         23. Has a history of an arterial thromboembolic event within the prior six months
             including cerebrovascular accident, transient ischemic attack, myocardial infarction,
             or unstable angina.

         24. Has uncontrolled human immunodeficiency virus (HIV) (defined as HIV RNA >500 copies/ml
             and CD4+ count<200/mm3 on antiretroviral therapy) infection or hepatitis B (defined as
             ALT > 1 x ULN, and HBV DNA >2000 IU/ml) or hepatitis C (defined as ALT > 1 x ULN,
             persistent viremia on antiviral therapy) infections.

         25. Has any clinically significant infection, i.e., any acute viral, bacterial, or fungal
             infection that requires specific treatment (anti-infective treatment has to be
             completed ≥ 7 days prior to study entry)

         26. Has any other severe, uncontrolled medical condition, including uncontrolled diabetes
             mellitus (defined as a Hemoglobin A1C≥ 9% in patients with a prior history of
             diabetes, 28 days prior to study ) or clinical signs of unstable congestive heart
             failure (Stage III-IV of the New York Heart Association Functional Classification)
             (Appendix 5).

         27. Radiation therapy to more than 25% of the bone marrow. Whole pelvic radiation is
             considered to be over 25%.

         28. Prior allogeneic bone marrow or organ transplantation.

         29. > Grade 1 peripheral neuropathy within 14 days before enrollment.

         30. Pregnant or breastfeeding - temozolomide is Pregnancy Category D - can cause fetal
             harm. Confirmation that the subject is not pregnant must be established by a negative
             serum beta-human chorionic gonadotropin (beta-hCG) pregnancy test result obtained
             during screening. Pregnancy testing is not required for post-menopausal or surgically
             sterilized women.

         31. Patient has received other investigational drugs within 14 days prior to study
             treatment.

         32. Other severe acute or chronic medical or psychiatric conditions or laboratory
             abnormality that may increase the risk associated with study participation or
             investigational product administration or may interfere with the interpretation of
             study results and, in the judgment of the investigator, would make the patient
             inappropriate for enrollment in this study.

         33. Abnormalities on 12-lead electrocardiogram (ECG) considered by the investigator to be
             clinically significant (such as acute ischemia, left bundle branch block, ventricular
             arrhythmias) or baseline prolongation of the rate-corrected QT interval (e.g.,
             repeated demonstration of QTc interval > 480 milliseconds).

         34. Presence of any non-healing wound, fracture, or ulcer within 28 days prior to the
             first dose of study drug.

         35. Has any condition that, in the opinion of the investigator, might jeopardize the
             safety of the patient or interfere with protocol compliance

         36. Has any mental or medical condition that prevents the patient from giving informed
             consent or participating in the trial