Inclusion Criteria:

          1. Patients with histologically-proven metastatic and/or unresectable melanoma (stage
             IIIc-IV, M1a-c as per AJCC 8th Edition), including mucosal melanoma, without evidence
             of active intra-cranial disease.

          2. Patients with tumor PD-L1 expression <1%.

          3. Patients are included regardless of BRAFV600 mutation status. BRAFV600 mutation status
             must be documented.

          4. Patients with a metastatic lesion located on liver, lung, or bone and eligible for a
             SBRT.

          5. Patients should present at least two lesions: one lesion to be irradiated and one
             distant lesion that will serve as control. Lesion to be irradiated will be selected on
             the basis of symptomatology, safety and/or location. Preferentially, both lesions
             should be measurable per RECIST 1.1. If only the control lesion is measurable but not
             the irradiated lesion, eligibility will be discussed with the sponsor.

          6. Age ≥18 years at the time of study entry.

          7. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1.

          8. Life expectancy of at least 3 months.

          9. Patients able to participate and willing to give informed consent prior to performance
             of any study-related procedures and to comply with the study protocol.

         10. Screening laboratory values must meet the following criteria and should be obtained
             prior to commencement of treatment:

               -  White blood count (WBC) ≥ 2000/μL

               -  Neutrophils ≥ 1500/μL

               -  Platelets ≥ 100 x103/μL

               -  Hemoglobin > 9.0 g/dL

               -  Serum creatinine ≤ 1.5 x ULN or creatinine clearance (CrCl) ≥ 40 mL/min (if using
                  the Cockcroft-Gault formula)

               -  AST/ALT ≤ 3 x ULN (except subjects with hepatic metastasis, who can have AST/ALT
                  ≤ 5 x ULN)

               -  Total Bilirubin ≤ 1.5 x ULN (except subjects with Gilbert Syndrome, who can have
                  total bilirubin < 3.0 mg/dL)

         11. Adequate cardiac and respiratory functions defined as New York Heart Association
             (NYHA) class 1 and SaO2 > 90%.

         12. Patient must be naïve to systemic treatment for locally advanced and/or metastatic
             disease (i.e., no prior systemic anticancer therapy for advanced disease; stage IIIc
             and IV). Prior adjuvant therapies (including Interferon α and Ipilimumab) is permitted
             if it was completed at least 12 weeks before start of treatment and all related AEs
             have either returned to baseline or stabilized.

         13. Prior radiotherapy or radiosurgery must have been completed at least 4 weeks prior to
             the first dose of the study treatment.

         14. Women of childbearing potential (WOCBP) must use two appropriate methods of
             contraception to avoid pregnancy for 23 weeks (30 days plus the time required for
             Nivolumab/Ipilimumab to undergo five half-lives) after the last dose of
             investigational drug.

         15. Women of childbearing potential must have a negative serum or urine pregnancy test
             (minimum sensitivity 25IU/L or equivalent units of HCG) within 24 hours prior to the
             start of study treatment.

         16. Men who are sexually active with WOCBP must use two contraceptive methods including at
             least one method with a failure rate of less than 1% per year for a period of 31 weeks
             after the last dose of investigational product. Women who are not of childbearing
             potential (i.e., who are postmenopausal or surgically sterile) as well as azoospermic
             men do not require contraception

         17. Absence of any psychological, familial, sociological or geographical condition that
             potentially hampers compliance with the study protocol and follow-up after treatment
             discontinuation schedule.

         18. Patient affiliated to a Social Health Insurance in France.

        Exclusion Criteria:

          1. Patient pregnant, or breast-feeding.

          2. Uveal melanoma.

          3. Active and/or symptomatic intra cranial metastasis (including melanomatous
             meningitis).

          4. Previous treatment with B-RAF or MEK inhibitors within 12 weeks prior start of
             treatment.

          5. Hypersensitivity to the drugs of the study.

          6. Any condition requiring systemic treatment with either corticosteroids (> 10 mg daily
             prednisone equivalents) or other immunosuppressive medications within 14 days of study
             drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg
             daily prednisone equivalents are permitted in the absence of active autoimmune
             disease.

          7. Clinically significant cardiac dysfunction including congenital, familial, and genetic
             cardiac disorders, current instable angina, current symptomatic congestive heart
             failure of NYHA class 2 and higher, current uncontrolled hypertension ≥ grade 3; Left
             Ventricular Ejection Fraction (LVEF) below institutional lower limit of normal (LLN)
             or below 50%, whichever is lower.

          8. Patient with active malignancy other than melanoma or a history of previous within the
             past 3 years; except for patients with resected Basal cell carcinoma or resected
             Spindle cell carcinoma, resected carcinoma in situ of the cervix and resected
             carcinoma in situ of the breast.

          9. Active, known or suspected autoimmune disease including but not restricted to multiple
             sclerosis, optical nevritis and demyelinating neuropathy. Subjects are permitted to
             enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to
             autoimmune condition only requiring hormone replacement, psoriasis not requiring
             systemic treatment, or conditions not expected to recur in the absence of an external
             trigger.

         10. Positive test for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus
             (ribonucleic acid or HCV antibody) indicating acute or chronic infection.

         11. Known history of testing positive for human immunodeficiency virus (HIV) or known
             acquired immunodeficiency syndrome (AIDS).

         12. Vaccination with any live attenuated conventional vaccine within the 3 months
             preceding the start of study treatment.

         13. Any current severe or uncontrolled disease, including, but not limited to ongoing or
             active infection.

         14. Patient included in another study with an experimental molecule and/or procedure.

         15. Unwillingness or inability to provide written informed consent.

         16. Any psychological, familial, geographic or social situation, according to the judgment
             of investigator, potentially preventing the compliance of treatment and the study
             protocol.

         17. Patient who has forfeited his/her freedom by administrative or legal award or who is
             under guardianship.