Key Inclusion Criteria:

          1. Age18 years.

          2. Signed Informed Consent Form.

          3. Histologically confirmed locally advanced or metastatic (Stage IIIB or IV) NSCLC of
             either squamous or non-squamous histology types with disease progression during or
             following treatment with at least one platinum-containing regimen, but no more than 2
             lines of systemic therapy.

          4. Participants must be able to provide fresh or archival tumor tissues for central
             assessment of PD-L1 expression in tumor cells. Participants with non-squamous
             histology must provide evidence of not harboring sensitizing EGFR mutation tested by a
             histology-based method.

          5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1.

          6. Adequate hematologic and end-organ function.

          7. Expected life span > 12 weeks.

          8. Willing to be compliance with birth control requirement during pre-specified study
             participating period

        Key Exclusion Criteria:

          1. Prior therapies of docetaxel or treatment targeting PD-1, PD-L1 or CTLA-4.

          2. Harboring EGFR sensitizing mutation or ALK gene translocation.

          3. Unresolved side effects of Grade 2 and above from prior anti-cancer therapies, except
             for AEs not constituting a likely safety risk (e.g. alopecia, rash, pigmentation,
             specific lab abnormalities).

          4. History of severe hypersensitivity reactions to other mAbs.

          5. History of interstitial lung disease, non-infectious pneumonitis or participants with
             significantly impaired pulmonary function, or who require supplemental oxygen at
             baseline.

          6. With uncontrollable pleural effusion, pericardial effusion, or clinically significant
             ascites requiring interventional treatment.

          7. Active Leptomeningeal disease or uncontrolled, untreated brain metastasis.

          8. Severe chronic or active infection requiring systemic treatment.

          9. Known HIV infection, participants with untreated chronic hepatitis B, active
             vaccination treatment.

         10. Insufficient cardiac functions and other underlying unfavorable cardiovascular
             conditions.

         11. Prior allogeneic stem cell transplantation or organ transplantation.

         12. Active autoimmune diseases or history of autoimmune diseases that may relapse.

         13. With conditions requiring systemic treatment with either corticosteroids (>10 mg daily
             prednisone or equivalent) or other immunosuppressive medications.

         14. With severe underlying medical conditions (including laboratory abnormalities) or
             alcohol or drug abuse that may affect the explanation of drug toxicity or AEs or
             result in impaired compliance with study conduct.

        NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.