Inclusion Criteria:

        Patients eligible for inclusion in this study have to meet all of the following criteria:

          1. Written informed consent must be obtained prior to any screening procedures.

          2. Patients must be 18 years of age or older at the time of signing informed consent.

          3. Patients must have a documented unequivocal diagnosis of AML according to WHO 2008
             classification. A bone marrow or blood blast count of ≥ 20% is required, except for
             AML with t(15;17), t(8;21), inv(16) or t(16;16) where blast count may be <20%, and,
             excluding M3 (acute promyelocytic leukemia).

          4. Patients with secondary AML are eligible, e.g. patients with antecedent history of
             treatment for prior malignancy. AML patients with a history of antecedent treatment
             for myelodysplasia (MDS), e.g. azacitidine or decitabine, remain eligible for
             treatment on this study. These agents must have been discontinued for a period of at
             least 30 days or 5 half-lives of the drug (whichever is greater) before midostaurin
             can be administered.

          5. Patients must have started "7+3" or "5+2" first induction chemotherapy regimen.

          6. Patients must have a documented FLT3 mutation (ITD or TKD).).

          7. Patients must have an ECOG Performance Status of ≤ 2

          8. Patients requiring intrathecal chemotherapy must have a minimum washout of 48 hours
             prior to the first dose of midostaurin

          9. Patients must have Total Bilirubin ≤ 2.5 x ULN

         10. Patients must have Serum Creatinine ≤ 2.5 x ULN

         11. Patients must be able to communicate well with the investigator to understand and
             comply with the requirements of the study

         12. Women of child-bearing potential must have a negative pregnancy test before starting
             use of midostaurin.

        Exclusion criteria:

        Patients eligible for this study must not meet any of the following criteria:

          1. Prior therapy for AML with the following exceptions:

               1. emergency leukapheresis

               2. emergency treatment for hyperleukocytosis with hydroxyurea for ≤ 7 days

               3. cranial RT for CNS leukostasis (one dose only)

               4. growth factor/cytokine support

          2. Patients with LVEF less than 45% (by echocardiogram or MUGA) or symptomatic congestive
             heart failure (Class III or IV) according to New York Heart Association (NYHA)
             classification

          3. Patients with any pulmonary infiltrate including those suspected to be of infectious
             origin (unless resolved to ≤ Grade 1 within screening timeframe)

          4. Patients with any uncontrolled illness, including, but not limited to, acute or
             chronic pancreatitis or uncontrolled infection

          5. QTc >470 msec on screening ECG.

          6. History of hypersensitivity to any drugs or metabolites of similar chemical classes as
             the study treatment.

          7. Participation in a prior investigational interventional (drug) study with
             administration of the investigational product within 30 days or 5 half-lives of the
             investigational product, whichever is longer.

          8. Pregnancy statements and contraception requirements:

             Women of child-bearing potential, defined as all women physiologically capable of
             becoming pregnant, unless they are using highly effective methods of contraception
             during dosing and for at least 4 months after stopping medication. Highly effective
             contraception methods include:

               -  Total abstinence (when this is in line with the preferred and usual lifestyle of
                  the subject). Periodic abstinence (e.g. calendar, ovulation, symptothermal,
                  post-ovulation methods) and withdrawal are not acceptable methods of
                  contraception

               -  Female sterilization (have had surgical bilateral oophorectomy with or without
                  hysterectomy), total hysterectomy, or tubal ligation at least six weeks before
                  taking study treatment. In case of oophorectomy alone, only when the reproductive
                  status of the woman has been confirmed by follow up hormone level assessment

               -  Male sterilization (at least 6 months prior to screening). The vasectomized male
                  partner should be the sole partner for that subject

               -  Use of oral, injected or implanted hormonal methods of contraception or placement
                  of an intrauterine device or intrauterine system, or other forms of hormonal
                  contraception that have comparable efficacy (failure rate <1%), for example
                  hormone vaginal ring or transdermal hormone contraception.

             In case of use of oral contraception women should also add a barrier method of
             contraception, particularly as it is currently unknown whether midostaurin may reduce
             the effectiveness of hormonal contraceptives.

             Sexually-active males unless they use a condom during intercourse with females of
             reproductive potential or pregnant women and for at least 4 months after stopping
             treatment to avoid conception or embryo-fetal harm.

          9. Patients enrolled in this study are not permitted to participate in additional
             parallel study drug or device studies.