Inclusion Criteria

          1. Radiographically confirmed solid tumor brain metastases

          2. Criteria for surgical resection of at least one metastasis per neurosurgeon discretion

          3. A diagnostic MRI Brain or CT Head demonstrating the presence of 1-4 solid tumor brain
             metastases and lesion to be resected no more than 5 cm in any direction, performed
             within 30 days prior to stereotactic radiosurgery. If multiple lesions are present,
             then the total brain metastases volume can be no more than 30 cm3 excluding the lesion
             to be resected.

          4. For known primary included in brainmetgpa.com, an estimated median survival no less
             than 6 months per brainmetgpa.com

          5. For unknown primary or known primary not included within brainmetgpa.com, an estimated
             median survival no less than 6 months per PI discretion Note: If patient's estimated
             median survival is calculated using a histology that is different than the histology
             demonstrated in final pathology, the patient may remain eligible for all study
             endpoints per PI discretion

          6. Surgical candidate per neurosurgeon discretion

          7. Surgical resection able to be performed within 1 - 4 days after radiosurgery

          8. Stereotactic radiosurgery candidate per radiation oncologist

          9. ≥ 18 years old at the time of informed consent

         10. Ability to provide written informed consent and HIPAA authorization. This will be
             assessed by the consenting physician using general questions to determine the
             patient's ability to understand the medical problem, proposed treatment, alternatives
             to proposed treatment, and understand the consequences of the medical choices.

         11. Platelet count > 100 k/cumm, Hgb > 7.5 gm/dL, INR < 1.3, ANC > 1.5 k/cumm

         12. Patients currently on cytotoxic chemotherapy or immunotherapy are eligible, not
             including anti-VEGF therapy

         13. If a patient who meets all stated eligibility criteria is enrolled on study and then
             discovered to be ineligible, the tissue obtained will still be deemed eligible to
             remain in study for evaluation.

        Exclusion Criteria

          1. Patients who received anti-VEGF therapy within 6 weeks prior to enrollment, as there
             is increased risk of fatal brain hemorrhage with surgical resection

          2. Major medical illnesses or psychiatric impairments, which in the investigator's
             opinion will prevent administration or completion of the protocol therapy and/or
             interfere with follow-up

          3. Patients with more than 4 brain metastases on MRI Brain or CT Head

          4. Lesion to be resected is more than 5 cm

          5. Total volume of metastatic disease more than 30 cm3 excluding lesion to be resected

          6. Patients with leptomeningeal metastases documented by MRI or CSF evaluation

          7. Previous whole brain radiation therapy

          8. Previous radiation therapy to lesion to be resected

          9. Planned adjuvant focal therapy including additional radiation therapy to the brain

         10. Not a surgical candidate per neurosurgeon's discretion

         11. Not a radiosurgical candidate per radiation oncologist's discretion

         12. Surgery unable to be performed between 1 - 4 days after radiosurgery

         13. Women who are pregnant or nursing are not eligible as treatment involves unforeseeable
             risks to the fetus or child