Inclusion Criteria:

          -  Existence of archival or fresh biopsy for FGFR testing. Mandatory FGFR testing of
             patients will be performed prior to start of screening. The timing of the FGFR test is
             at the discretion of the investigator. Investigators should ensure all patients will
             be eligible in terms of disease status and lines of treatment.

          -  Documented urothelial carcinoma (transitional cell carcinoma) including urinary
             bladder, renal pelvis, ureters, urethra meeting all of the following criteria

               -  Histologically confirmed (Patients with mixed histologies are required to have a
                  dominant transitional cell pattern.)

               -  Locally advanced (T4, any N; or any T, N 2-3) or metastatic disease (any T, any N
                  and M1). Locally advanced bladder cancer must be unresectable i.e. invading the
                  pelvic or abdominal wall (stage T4b) or presenting with bulky nodal disease
                  (N2-3).

          -  ECOG (Eastern Cooperative Oncology Group) Performance Status of 0 or 1

          -  Disease progression during or following treatment with at least one
             platinum-containing regimen (patients should have been treated for at least 2 cycles).
             In patients who received prior adjuvant/ neoadjuvant platinum-containing chemotherapy,
             progression had to occur within 12 months of treatment.

          -  High FGFR1 or 3 mRNA expression levels in archival or fresh tumor biopsy specimen
             quantified as outlined in the lab manual

          -  At least 1 measurable lesion according to Response Evaluation Criteria in Solid Tumors
             (RECIST v.1.1) in contrast enhanced (unless contraindicated) CT or MRI

        Exclusion Criteria:

          -  Previous or concurrent cancer except

               -  cervical carcinoma in situ

               -  treated basal-cell or squamous cell skin carcinoma

               -  any cancer curatively treated > 3 years before randomization

               -  curatively treated incidental prostate cancer (T1/T2a)

          -  Ongoing or previous treatment with anti-FGFR directed therapies (e.g. receptor
             tyrosine kinase inhibitors including rogaratinib or FGFR-specific antibodies) or with
             taxanes or vinflunine

          -  More than two prior lines of systemic anti-cancer therapy for urothelial carcinoma
             given for advanced unresectable/ metastatic disease

          -  Ongoing or previous anti-cancer treatment within 4 weeks before randomization.

          -  Unresolved toxicity higher than National Cancer Institute's Common Terminology
             Criteria for Adverse Events, version 4.03 (CTCAE v.4.03) Grade 1 attributed to any
             prior therapy/ procedure excluding alopecia, anemia and/ or hypothyroidism

          -  History or current condition of an uncontrolled cardiovascular disease including any
             of the following conditions:

               -  Congestive heart failure (CHF) NYHA (New York Heart Association) > Class 2

               -  Unstable angina (symptoms of angina at rest) or new-onset angina (within last 3
                  months before randomization)

               -  Myocardial infarction (MI) within past 6 months before randomization

               -  Unstable cardiac arrhythmias requiring anti-arrhythmic therapy. Patients with
                  arrhythmia under control with anti-arrhythmic therapy such as beta-blockers or
                  digoxin are eligible.

          -  Arterial or venous thrombotic events or embolic events such as cerebrovascular
             accident (including transient ischemic attacks), deep vein thrombosis or pulmonary
             embolism within 3 months before randomization

          -  Current evidence of endocrine alteration of calcium phosphate homeostasis (e.g.
             parathyroid disorder, history of parathyroidectomy, tumor lysis, tumoral calcinosis,
             paraneoplastic hypercalcemia)

          -  Current diagnosis of any retinal detachment, retinal pigment epithelial detachment
             (RPED), serous retinopathy or retinal vein occlusion

          -  Any hemorrhage / bleeding event ≥ CTCAE v.4.03 Grade 3 within 4 weeks before
             randomization