Clinical Trials /

Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation

NCT03434730

Description:

The aim of the research in this study is to make participants' transplant safer by reducing the risk of developing GVHD and GVHD-related complications by giving participants a dose of the drug tocilizumab in addition to the standard approach for GVHD prevention. Tocilizumab reduces the risk of inflammation by blocking the effect of Interleukin-6, a protein that exists in high levels in the blood when there is inflammation. Participants who receive stem cell transplants have high levels of this protein in their blood early after transplant. Therefore, the goal of this study is to reduce the risk of inflammation after transplant with the addition of Tocilizumab. This could decrease the risk of developing GVHD and GVHD-associated complications.

Related Conditions:
  • Acute Leukemia
  • Acute Leukemia of Ambiguous Lineage
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Aggressive Non-Hodgkin Lymphoma
  • B-Cell Non-Hodgkin Lymphoma
  • Blastic Plasmacytoid Dendritic Cell Neoplasm
  • Burkitt Lymphoma
  • Diffuse Large B-Cell Lymphoma
  • Follicular Lymphoma
  • Hodgkin Lymphoma
  • Mantle Cell Lymphoma
  • Marginal Zone Lymphoma
  • Myelodysplastic/Myeloproliferative Neoplasm
  • Non-Hodgkin Lymphoma
  • T-Cell Non-Hodgkin Lymphoma
Recruiting Status:

Recruiting

Phase:

Phase 2

Trial Eligibility

Document

Title

  • Brief Title: Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation
  • Official Title: A Phase II Study of IL-6 Receptor Blockade to Ameliorate Acute Graft Versus Host Disease and Early Toxicity After Double Unit Cord Blood Transplantation in Adults With Hematologic Malignancies.

Clinical Trial IDs

  • ORG STUDY ID: 17-616
  • NCT ID: NCT03434730

Conditions

  • Acute Myeloid Leukemia
  • Acute Lymphoblastic Leukemia
  • Acute Leukemia
  • Myelodysplastic Syndromes
  • Myelodysplastic-Myeloproliferative Diseases
  • Myeloproliferative Disorder
  • Non Hodgkin Lymphoma
  • Hodgkin Lymphoma
  • Leukemia

Interventions

DrugSynonymsArms
CyclosporineSandimmuneAdult Participants With High Risk Hematologic Malignancies
Mycophenolate MofetilCellCeptAdult Participants With High Risk Hematologic Malignancies
TocilizumabAcemtraAdult Participants With High Risk Hematologic Malignancies
FilgrastimGranulocyte-Colony Stimulating Factor, NeupogenAdult Participants With High Risk Hematologic Malignancies

Purpose

The aim of the research in this study is to make participants' transplant safer by reducing the risk of developing GVHD and GVHD-related complications by giving participants a dose of the drug tocilizumab in addition to the standard approach for GVHD prevention. Tocilizumab reduces the risk of inflammation by blocking the effect of Interleukin-6, a protein that exists in high levels in the blood when there is inflammation. Participants who receive stem cell transplants have high levels of this protein in their blood early after transplant. Therefore, the goal of this study is to reduce the risk of inflammation after transplant with the addition of Tocilizumab. This could decrease the risk of developing GVHD and GVHD-associated complications.

Trial Arms

NameTypeDescriptionInterventions
Adult Participants With High Risk Hematologic MalignanciesExperimental
  • Cyclosporine
  • Mycophenolate Mofetil
  • Tocilizumab
  • Filgrastim

Eligibility Criteria

        Inclusion Criteria:

        I. Acute myelogenous leukemia (AML)

          -  Complete first remission (CR1) at high risk for relapse such as any of the following:

          -  Known prior diagnosis of myelodysplasia (MDS) or myeloproliferative disorder

          -  Therapy-related AML

          -  White cell count at presentation > 100,000

          -  Presence of extramedullary leukemia at diagnosis

          -  Any unfavorable subtype by FAB or WHO classification

          -  High-risk cytogenetics (e.g. those associated with MDS, abnormalities of 5, 7, 8,
             complex karyotype) or high risk molecular abnormalities

          -  Requirement for 2 or more induction to achieve CR1

          -  Any patient with newly diagnosed AML with intermediate risk cytogenetics who elects
             allograft with curative intent over consolidation chemotherapy

          -  Any patient unable to tolerate consolidation chemotherapy as would have been deemed
             appropriate by the treating physician

          -  Other high risk features not defined above

          -  Complete second remission (CR2)

          -  Primary refractory or relapsed AML with less than 10% blasts before transplant.
             Persistent/relapsed AML with cytogenetic, flow cytometric, or molecular aberrations in
             >/= 10% of cells are eligible

        II. Acute lymphoblastic leukemia (ALL)

          -  Complete first remission (CR1) at high risk for relapse such as any of the following:

          -  White cell count at presentation > 30,000 for B-cell lineage and > 100,00 for T-cell
             lineage

          -  Presence of any high-risk cytogenetic abnormalities such as t(9;22), t(1;19), t(4;11)
             or other MLL rearrangements (11q23) or other high-risk molecular abnormality

          -  Failure to achieve complete remission after four weeks of induction therapy

          -  Persistence or recurrence of minimal residual disease on therapy

          -  Any patient with newly diagnosed ALL >/= 50 years-old

          -  Any patient unable to tolerate consolidation and/or maintenance chemotherapy as would
             have been deemed appropriate by the treating physician

          -  Other high risk features not defined above

          -  Complete second remission (CR2)

          -  Primary refractory or relapsed ALL with less than 5% blasts before transplant.
             Persistent/relapsed ALL with cytogenetic, flow cytometric or molecular aberrations in
             >/=5% of cells are eligible.

        III. Other acute leukemias: leukemias of ambiguous lineage or of other types e.g. blastic
        plasmacytoid dendritic cell neoplasm with less than 5% blasts. Persistent/relapsed disease
        with cytogenetic, flow cytometric or molecular aberrations in >/=5% of cells are eligible

        IV. Myelodysplastic Syndrome (MDS)/ Myeloproliferative Disorders (MPD) other than
        myelofibrosis:

          -  International prognostic scoring system (IPSS) risk score of INT-2 or high risk at the
             time of diagnosis

          -  Any IPSS risk category if life-threatening cytopenia(s) exists

          -  Any IPSS risk category with karyotype or genomic changes that indicate high risk for
             progression to acute myelogenous leukemia

          -  MDS/ myeloproliferative disorder overlap syndromes without myelofibrosis

          -  MDS/ MPD patients must have less than 10% bone marrow myeloblasts and ANC >/= 0.2
             (growth factor supported if necessary) at transplant work-up

        V. Non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL) at high-risk of relapse or
        progression if not in remission:

          -  Eligible patients with aggressive histologies (such as, but not limited to, diffuse
             large B-cell NHL, mantle cell NHL, and T-cell histologies) in CR

          -  Eligible patients with indolent B cell NHL (such as, but not limited to, follicular,
             small cell or marginal zone NHL) will have 2nd or subsequent progression with stable
             disease/CR/PR with no single lesion equal to or more than 5 cm.

          -  Eligible patients with HL will be without progression of disease (POD) after salvage
             chemotherapy with no single lesion equal to or more than 5cm.

        Organ Function and Performance Status Criteria:

          -  Karnofsky score >/= 70% (inpatient Leukemia service transfers without discharge are
             acceptable provided patient has equivalent KPS as if were outpatient)

          -  Calculated creatinine clearance >/= 60 ml/min

          -  Bilirubin < 1.5 mg/dL (unless benign congenital hyperbilirubinemia)

          -  ALT </= 3 x upper limit of normal

          -  Pulmonary function (spirometry and corrected DLCO) >/= 50% predicted

          -  Left ventricular ejection fraction >/= 50%

          -  Albumin >/= 3.0

          -  Age-adjusted Hematopoietic Cell Transplantation-Comorbidity Index (aaHCT-CI) less than
             or equal to 7

        Graft Criteria:

        2 CB units will be selected according to current MSKCC unit selection algorithm. High
        resolution 8 allele HLA typing and recipient HLA antibody profile will be performed. Unit
        selection will occur based on HLA-match, total nucleated cell (TNC) and CD34+ cell dose
        adjusted per patient body weight. The bank of origin will also be taken into account. Donor
        specific HLA antibodies, if present, will also be taken into consideration and may
        influence the selection of the graft.

          -  Each CB unit must be at least 3/8 HLA-matched to the patient considering high
             resolution 8-allele HLA typing

          -  Each CB unit will be required to have a cryopreserved TNC dose of at least 1.5 x 10^7
             TNC/ recipient body weight (TNC/ kg)

          -  Each CB unit will be required to have a cryopreserved CD34+ cell dose of at least 1.0
             x 10^5 CD34+ cells/ recipient body weight (CD34+/kg).

          -  A minimum of one domestic will be reserved as a backup unit.

        Exclusion Criteria:

          -  Indolent NHL or Hodgkin lymphoma with POD after most recent salvage chemotherapy

          -  Diagnosis of myelofibrosis or other malignancy with moderate-severe bone marrow
             fibrosis

          -  Any diagnosis without prior immunosuppressive chemotherapy within 3 months of intended
             admission for transplant

          -  Prior checkpoint inhibitors/ blockade in the last 12 months

          -  Two prior stem cell transplants of any kind

          -  One prior autologous stem cell transplant within the preceding 12 months

          -  One prior allogeneic stem cell transplant within the preceding 24 months

          -  Prior radiation therapy with 400cGy or more of TBI

          -  Active and uncontrolled infection at time of transplantation

          -  HIV infection

          -  Seropositivity for HTLV-1.

          -  Inadequate performance status/ organ function.

          -  Pregnancy or breast feeding

          -  Patient or guardian unable to give informed consent or unable to comply with the
             treatment protocol including appropriate supportive care, long-term follow-up, and
             research tests.
      
Maximum Eligible Age:65 Years
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Incidence of grade II-IV aGVHD by day 100 after study treatment
Time Frame:100 days post treatment
Safety Issue:
Description:

Details

Phase:Phase 2
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:Memorial Sloan Kettering Cancer Center

Trial Keywords

  • tocilizumab
  • 17-616
  • Memorial Sloan Kettering Cancer Center

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