Inclusion Criteria:

          1. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1.

          2. Documented incurable cancer with one of the following histologies: nonsmall cell lung
             cancer, renal cell cancer, triple negative breast cancer, colorectal cancer with
             microsatellite instability(MSI), bladder cancer, cervical cancer, uterine cancer,
             sarcoma, endometrial cancer, and metastatic castration resistant prostate cancer.

          3. At least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST
             1.1).

          4. For Escalation: At least 1 but not more than 5 prior systemic therapies for advanced/
             recurrent or progressing disease. For Expansion: Subject must have progressed on, be
             refractory to, or intolerant to 1-3 prior systemic therapies.

          5. Willingness to provide tumor biopsies.

        Exclusion Criteria

          1. History of severe hypersensitivity reaction to monoclonal antibodies.

          2. Subjects who have received prior therapy with regimens containing
             cytotoxicT-lymphocyte antigen-4 (CTLA-4), programmed cell death ligand 1 (PDL1), or
             PD1 antagonists are NOT permitted to enroll unless all adverse events (AEs) while
             receiving prior immunotherapy have resolved to Grade 1 or baseline prior to screening.

          3. History of (non-infectious) pneumonitis that required steroids or subject has current
             pneumonitis.

          4. The use of any investigational medication or device in the 30 days prior to screening
             and throughout the study is prohibited.

          5. Symptomatic, untreated, or actively progressing central nervous system (CNS)
             metastases.