Inclusion Criteria:

          -  Subjects must be ≥ than 6 months and ≤ 30 years of age at the time of study
             enrollment.

          -  Subjects must have had histologic verification of a malignancy at original diagnosis
             or relapse.

               -  All subjects with relapsed or refractory solid tumors are eligible, excluding
                  primary CNS tumors.

               -  Patients with solid tumors and a history of intraparenchymal CNS disease are
                  eligible if their CNS disease was treated surgically or with radiotherapy and
                  stable with no recurrent lesions for at least 3 months from the start of protocol
                  therapy.

               -  Newly diagnosed patients with ≤15% chance of cure if given standard-of-care
                  chemotherapy are eligible. (Prognosis to be determined at the discretion of the
                  treating physician.)

          -  Subjects must have either measurable or evaluable disease.

          -  Karnofsky ≥ 60 for subjects > 16 years of age and Lansky ≥ 50 for subjects ≤ 16 years
             of age. Subjects who are unable to walk because of paralysis, but who are up in a
             wheelchair, will be considered ambulatory for the purpose of assessing the performance
             score.

          -  Subjects must have fully recovered from the acute toxic effects of all prior
             anti-cancer chemotherapy.

               -  At least 21 days after the last dose of myelosuppressive chemotherapy (42 days if
                  prior nitrosourea).

               -  At least 14 days after the last dose of a long-acting growth factor (e.g.
                  Pegfilgrastim) or 7 days for short acting growth factor. For agents that have
                  known adverse events occurring beyond 7 days after administration, this period
                  must be extended beyond the time during which adverse events are known to occur.
                  The duration of this interval must be discussed with the study chair.

               -  At least 7 days after the last dose of a biologic agent. For agents that have
                  known adverse events occurring beyond 7 days after administration, this period
                  must be extended beyond the time during which adverse events are known to occur.
                  The duration of this interval must be discussed with the study chair.

               -  ≥ 42 days must have elapsed from last dose of any type of cellular therapy (e.g.
                  modified T cells, natural killer (NK) cells, dendritic cells, etc.)

               -  ≥ 21 days must have elapsed from the last dose of interleukins, interferon or
                  cytokines (other than Hematopoietic Growth Factors).

               -  ≥ 21 days must have elapsed from infusion of last dose of antibody, and toxicity
                  related to prior antibody therapy must be recovered to Grade ≤ 1.

               -  At least 14 days after local palliative radiation therapy (XRT) (small port); 6
                  weeks must have elapsed since treatment with therapeutic doses of iodine-131
                  metaiodobenzylguanidine (131I-MIBG); At least 42 days must have elapsed if other
                  substantial bone marrow (BM) radiation.

               -  No evidence of active graft vs. host disease and at least 84 days must have
                  elapsed after transplant and 42 days for autologous stem cell infusion after
                  131I-MIBG therapy.

               -  Patients who have previously received a taxane, including nab-paclitaxel, or a
                  nucleoside analogue, including gemcitabine, are eligible as long as they have not
                  received gemcitabine in combination with nab-paclitaxel.

               -  ≥72 hours must have elapsed since the last administration of medical cannabis and
                  cannabidiol (CBD Oil).

               -  ≥30 days must have elapsed since the last dose of any agents not specified above.
                  For agents with an uncertain washout period or for any questions or uncertainty
                  the study PI should be notified.

          -  Adequate bone marrow function defined as:

               -  For subjects with solid tumors without known bone marrow involvement: Peripheral
                  absolute neutrophil count (ANC) ≥ 750/mm3. Platelet count ≥ 75,000/mm3
                  (transfusion independent, defined as not receiving platelet transfusions for at
                  least 7 days prior to enrollment)

               -  Subjects with known bone marrow metastatic disease will be eligible for study
                  provided they meet the blood counts of peripheral absolute neutrophil count (ANC)
                  ≥ 750/mm3 and platelet count ≥ 75,000/mm3 (may receive transfusions provided they
                  are not known to be refractory to red cell or platelet transfusions). These
                  subjects will not be evaluable for hematologic toxicity. At least 5 of every
                  cohort of 6 patients must be evaluable for hematologic toxicity for the
                  dose-escalation part of the study. If dose-limiting hematologic toxicity is
                  observed, all subsequent subjects enrolled must be evaluable for hematologic
                  toxicity.

          -  Adequate renal function defined as:

               -  Creatinine clearance or radioisotope glomerular filtration rate (GFR)
                  70ml/min/1.73 m^2 or

               -  A serum creatinine based on age/gender using threshold creatinine values derived
                  from the Schwartz formula for estimating GFR utilizing child length and stature
                  data published by the Centers for Disease Control and Prevention (CDC).

          -  Adequate liver function defined as:

               -  Bilirubin (sum of conjugated + unconjugated) ≤ 1.5 x upper limit of normal (ULN)
                  for age

               -  Serum glutamic pyruvic transaminase (SGPT) (ALT) ≤ 5 x the ULN. For the purpose
                  of this study, the ULN for SGPT is 45 U/L.

        Exclusion Criteria:

          -  Female patients who are pregnant are ineligible for study. Lactating females are not
             eligible unless they have agreed not to breastfeed their infants from the time of
             informed consent through the duration and at least 1 month following the last dose of
             investigational agent. Female patients of childbearing potential are not eligible
             unless a negative pregnancy test result has been obtained. Sexually active patients of
             reproductive potential are not eligible unless they have agreed to use an effective
             contraceptive method from the time of informed consent through the duration and for 1
             month following the last dose of investigational agent. The definition of an effective
             contraceptive method will be at the discretion of the institutional investigator.

          -  Patients taking any the following concomitant medications are not eligible:

               -  Subjects who are currently receiving another investigational drug.

               -  Subjects who are currently receiving other anti-cancer agents.

               -  Subjects who are receiving cyclosporine, tacrolimus, or other agents to prevent
                  graft-versus-host disease post bone marrow transplant.

               -  Subjects using medications which interfere with CYP3A4 and CYP2C8 metabolism,
                  which metabolize nab-paclitaxel. Paclitaxel is metabolized by CYP3A4 and CYP2C8,
                  so strong inhibitors or inducers of these enzymes should be avoided.

          -  Patients with any of the following adverse events at the time of enrollment are not
             eligible:

               -  Grade ≥ 2 Motor, sensory or peripheral neuropathy. This does not apply to
                  patients with neuropathic symptoms related to tumor or prior therapy, i.e.
                  surgery or radiation. Patients with mild neuropathy well controlled with
                  medications are eligible.

               -  Grade ≥3 Hyponatremia (serum Na ≤ 130 mmol/L)

          -  Subjects who have an uncontrolled infection are not eligible.

          -  Subjects who have received prior solid organ transplantation are not eligible.

          -  Subjects who in the opinion of the investigator may not be able to comply with the
             safety monitoring requirements of the study are not eligible.