Inclusion Criteria:

          1. Written informed consent obtained prior to any study-related procedure being
             performed;

          2. Age 18 years or older;

          3. Patients with histologically or cytologically confirmed, advanced solid tumors which
             have progressed despite standard therapy or for whom no standard therapy exists;

          4. Patients with life expectancy ≥3 months;

          5. Patients must have at least one measurable lesion as defined by RECIST v1.1;

          6. Eastern Cooperative Oncology Group performance score 0 or 1;

          7. Patients who have sufficient baseline organ function.

        Exclusion Criteria:

          1. Patients with life-threatening autoimmune disease or with autoimmune disorder and who
             are on long-term steroid treatment;

          2. History or current evidence of retinal vein occlusion (RVO) or current risk factors
             for RVO;

          3. Known malignant central nervous system (CNS) disease other than neurologically stable,
             treated brain metastases;

          4. Active infection including hepatitis B, hepatitis C and human immunodeficiency virus
             (HIV)

          5. Patients who have any severe and/or uncontrolled medical conditions or other
             conditions that, in the opinion of the Investigator and Sponsor, could affect the
             patient's participation in the study

          6. Patients who have impaired cardiac function or clinically significant cardiac
             diseases;

          7. Use of anti-cancer treatment drug ≤21 days or 5 half-lives (whichever is shorter)
             prior to the first dose of JAB-3068;

          8. Use of an investigational drug during the past 30 days or 5 half-lives (whichever is
             shorter) prior to the first dose of JAB-3068;

          9. No other anti-cancer therapy (chemotherapy, immunotherapy, hormonal therapy
             radiotherapy (except for palliative local radiotherapy), biological therapy or other
             novel agent is to be permitted while the patient is receiving study medication.