Inclusion Criteria:

        Subjects with histologically or cytologically confirmed, unresectable stage IIIB/IV NSCLC
        that carries a V600 BRAF mutation, as per NGS ECOG performance status of 0 to 2 Male or
        female; ≥ 18 Subjects with measurable lesion (using RECIST 1.1 criteria) Subjects must have
        archival tissue sample available, collected either at the time of diagnosis of NSCLC or any
        time since Patients who have progressed during or after 1st line or 2nd line therapy prior
        to the first dose of dabrafenib/trametinib. For patient who have received prior platinum
        containing adjuvant, neoadjuvant, or definitive chemoradiation for locally advanced
        disease, those treatments are regarded as 1st line if the progression has occurred < 12
        months from last therapy.

        Subjects who meet the following criteria:

        Absolute neutrophil count (ANC) >1.5 x 109/L Platelet count >100 x 109/L Serum creatinine
        >1.5 x upper limit of normal (ULN) AST (SGOT) and ALT (SGPT) > 3 x upper limit of normal
        (ULN) (If there is Liver Metastasis > 5 x upper limit of normal (ULN)) Total bilirubin>1.5
        x upper limit of normal (ULN) the progression has occurred < 12 months from last therapy.
        Patients with asymptomatic brain metastasis could be eligible. Provision of written
        informed consent prior to any study specific procedures

        Exclusion Criteria:

        Any major operation or irradiation within 4 weeks of baseline disease assessment Any
        clinically significant gastrointestinal abnormalities which may impair intake or absorption
        of the study drug Subjects with symptomatic central nervous system (CNS) metastases who are
        neurologically unstable or have required increasing doses of steroids within the 2 weeks
        prior to study entry to manage CNS symptoms Subjects with chemotherapy naïve or those who
        already had received two lines of chemotherapy including immunotherapy or targeted therapy.

        Other co-existing malignancies or malignancies diagnosed within the last 3 years with the
        exception of basal cell carcinoma or cervical cancer in situ.

        Subjects with an uncontrolled major cardiovascular disease (including AMI within 12 months,
        unstable angina within 6 months, over NYHA class III congestive heart failure, congenital
        long QT syndrome, 2° or more AV Block and uncontrolled hypertension) Patients with known
        history of extensive disseminated bilateral interstitial fibrosis or interstitial lung
        disease, including a history of drug pneumonitis, hypersensitivity pneumonitis,
        obliterative bronchiolitis, and clinically significant radiation pneumonitis (i.e.
        affecting activities of daily living or requiring therapeutic intervention).

        Pregnant or lactating female Evidence of any other significant clinical disorder or
        laboratory finding that makes it undesirable for the patient to participate in the study

        Receiving medications that meet one of the following criteria and that cannot be
        discontinued at least 1 week prior to the start of treatment with IPs for the duration of
        participation:

        Medication with a known risk of prolonging the QT interval or inducing Torsades de Pointes
        (please refer to http://www.azcert.org/medical-pros/drug-lists/drug-lists.cfm) Strong
        inhibitors or strong inducers of CYP2C8 and CYP3A4 Unstable or increasing doses of
        corticosteroids enzyme-inducing anticonvulsive agents herbal supplements Patients who have
        received thoracic radiotherapy to lung fields ≤ 4 weeks prior to starting the study
        treatment or patients who have not recovered from radiotherapy-related toxicities. For all
        other anatomic sites (including radiotherapy to thoracic vertebrae and ribs), radiotherapy
        ≤ 2 weeks prior to starting the study treatment or patients who have not recovered from
        radiotherapy-related toxicities. Palliative radiotherapy for bone lesions ≤ 2 weeks prior
        to starting study treatment is allowed