Inclusion Criteria:

          1. Histologically or cytologically confirmed diagnosis of metastatic or locally advanced
             unresectable tumors

          2. Patients demonstrating disease progression after treatment with approved therapies
             that are known to confer life-prolonging benefit, or who are intolerant to or have
             declined treatment

          3. Agreement to provide mandatory archival tissue or fresh biopsy

          4. At least 18 years of age

          5. For Arm A, histologically or cytologically confirmed metastatic or locally advanced
             unresectable solid tumor

          6. For Arms B and C, histologically or cytologically confirmed metastatic or locally
             advanced unresectable HNSCC, DLBCL, NSCLC (squamous cell histology only), or
             esophageal (EAC, ESCC, or GE junction) cancer

          7. Additional inclusion criteria may apply

        Exclusion Criteria:

          1. Neuropathy > Grade 1

          2. Serious concurrent illness, including clinically relevant active infection

          3. Clinically significant iron metabolism disorders (eg, sickle cell anemia)

          4. Significant cardiac disease such as recent myocardial infarction

          5. History of multiple sclerosis or other demyelinating disease, Eaton-Lambert syndrome
             (para-neoplastic syndrome), history of hemorrhagic or ischemic stroke within the last
             6 months, or alcoholic liver disease;

          6. Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the
             underlying neoplasm;

          7. History of severe allergic or anaphylactic reactions to previous monoclonal antibody
             therapy;

          8. Currently receiving anticoagulation therapy with warfarin;

          9. Major surgery (requiring general anesthesia) within 3 months prior to dosing.

         10. Hepatic impairment which is moderate (Child-Pugh B) or severe (Child-Pugh C)

         11. Transfusion dependent anemia with transfusion dependency of ≥3 months

         12. Use of iron chelators

         13. Additional exclusion criteria may apply