Inclusion Criteria:

          -  Must have cytologically or histologically-confirmed unresectable melanoma that harbors
             a BRAF V600 mutation determined by pyrosequencing assay or equivalent genotyping assay
             in a Clinical Laboratory Improvement Amendments (CLIA) certified laboratory, meeting
             one of the following American Joint Committee on Cancer (AJCC) 8th edition staging
             criteria: a.) AJCC stage IV (Tany, Nany, M1a(1), M1b(1), M1c(1) or M1d(1)); b.) AJCC
             stage IIIC (at least N2b) or IIID with unresectable nodal/locoregional involvement.

          -  Must have serum LDH > institutional upper limit of normal (ULN) at time of study
             enrollment.

          -  Must have adequate hepatic, renal, and bone marrow function. There are no specific
             minimum criteria for enrollment; this will at the discretion of the treating
             physician, as any patient who would be considered for standard of care treatment with
             these drugs may be considered for this trial.

          -  Must have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤2.

          -  Willing to give written informed consent per institutional guidelines and must be able
             and willing to adhere to dose and visit schedules.

          -  Negative serum pregnancy test within 7 days prior to commencement of dosing in
             premenopausal women.

          -  Fertile men and women must use an effective method of contraception during treatment
             and for at least 6 months after completion of treatment as directed by their
             physician.

          -  Treatment-naïve and previously treated patients will be included; however, patients
             may not have received a BRAF or MEK inhibitor in the past 24 weeks.

          -  May have received prior systemic and/or radiation therapy. All adverse events
             associated with prior systemic therapy or radiation therapy must have resolved to ≤
             Grade 1 prior to start of study.

          -  Must have measurable disease as defined by Response Evaluation Criteria in Solid
             Tumors (RECIST) 1.1.

        Exclusion Criteria:

          -  Females who are pregnant, intend to become pregnant or are nursing.

          -  Have been previously treated with BRAF/MEK inhibitor therapy in the past 24 weeks.

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, or psychiatric illness/social situations that would limit compliance with
             study requirements. Patients with a baseline left ventricular ejection fraction of
             less than 40% will be ineligible.

          -  HIV-positive patients on combination antiretroviral therapy.

          -  Untreated or uncontrolled brain metastases. Patients with asymptomatic brain
             metastases or previously treated brain metastases that are stable (i.e., not requiring
             corticosteroids) at the time of study start will be eligible.

          -  Previous malignancy is not an exclusion provided that the other malignancy is
             considered under control, patient is not on concomitant anti-cancer drug therapy, and
             target lesions from melanoma are clearly defined for response assessment.

          -  Unwillingness or inability to comply with study and follow-up procedures.

          -  The following foods/supplements are prohibited at least 7 days prior to initiation of
             and during study treatment:St. John's wort or hyperforin (potent cytochrome P450
             CYP3A4 enzyme inducer); Grapefruit juice (potent cytochrome P450 CYP3A4 enzyme
             inhibitor).

          -  Ocular:History of or evidence of retinal pathology on baseline ophthalmologic
             examination that is considered a risk factor for neurosensory retinal detachment, RVO,
             or neovascular macular degeneration.