Inclusion Criteria:

          1. Ability to understand and voluntarily give informed consent.

          2. Male or female patients, age ≥18 years at the time of consent.

          3. Diagnosis of hematologic malignancy including, but not limited to, AML, ALL, and MDS.
             Patients may be newly diagnosed, refractory to initial treatment, or in relapse.

          4. Patients with normal renal function, or moderate or severe renal impairment as
             categorized by creatinine clearance (CrCl)) using the Cockcroft-Gault Formula.

          5. Consent of female patients to use a medically acceptable method of contraception for
             at least 2 months prior to the first dose of CPX-351 and consent of female patients to
             use a medically acceptable method of contraception throughout the entire study period
             and for 6 months following the last dose of CPX-351.

          6. Male patients must be willing to refrain from sperm donation for 6 months following
             the last dose of CPX-351and must use adequate contraception throughout the entire
             study period and for 6 months following the last dose of CPX-351.

        Exclusion Criteria:

          1. Prior treatment with CPX-351 ≤ to 1 month before the start of CPX-351 in this study.

          2. Patients with active (uncontrolled, metastatic) second malignancies are excluded.

          3. Any serious medical condition, laboratory abnormality, or psychiatric illness that
             would prevent obtaining informed consent.

          4. Patients with known hypersensitivity to cytarabine, daunorubicin, or liposomal
             products.

          5. Female patients who are pregnant, nursing, or lactating.

          6. Participation in another clinical trial of an investigational drug or medical device
             within 30 days or 5 half-lives (whichever is longer) prior to enrollment in this
             study.

          7. Any other condition that would cause a risk to patients if they participate in the
             trial.