Inclusion Criteria:

          -  Patients must have signed and dated an Institutional Review Board/Independent Ethics
             Committee -approved written informed consent form in accordance with regulatory and
             institutional guidelines. This must be obtained before the performance of any
             protocol-related procedures that are not part of normal patient care

          -  Patients must be willing and able to comply with scheduled visits, treatment schedule,
             laboratory tests, tumor biopsies, and other requirements of the study.

          -  All patients must be either Stage IIIb/c or Stage IV according to the American Joint
             Committee on Cancer (AJCC) (7th edition) and have histologically-confirmed melanoma
             that is felt to be surgically unresectable in order to be eligible. Please refer to
             the AJCC Cancer Staging Manual, 7th edition for a description of tumor, lymph node,
             metastasis and staging.

          -  All melanomas, except ocular/uveal melanoma, regardless of primary site of disease
             will be allowed; mucosal melanomas are eligible.

          -  Patients must not have received prior anticancer treatment for metastatic disease (for
             example, but not limited to, systemic, local, radiation, radiopharmaceutical).

          -  Exceptions: Surgery for melanoma and/or postresection brain radiotherapy (RT) if
             central nervous system (CNS) metastases and/or prior treatment with adjuvant
             interferon (IFN) (as described in Exclusion Criterion 2).

             --All patients must have their disease status documented by a complete physical
             examination and imaging studies within 4 weeks prior to the first dose of study drug.
             Imaging studies must include computerized tomography (CT) scan of neck, chest,
             abdomen, pelvis, and all known sites of resected disease in the setting of Stage
             IIIb/c or Stage IV disease, and brain magnetic resonance imaging ([MRI], brain CT
             allowable if MRI is contraindicated).

          -  The complete set of baseline radiographic images must be available before treatment
             initiation.

          -  Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.

          -  Tumor tissue from the resected site of disease must be provided for biomarker analyses

          -  Prior treated CNS metastases must be without MRI evidence of recurrence for at least 4
             weeks after treatment. Patients must be off immunosuppressive doses of systemic
             steroids (≥ 10 mg/day prednisone or equivalent) for at least 14 days prior to study
             drug administration, and must have returned to neurologic baseline status
             postoperatively

               -  The 4-week period of stability is measured after the completion of the neurologic
                  interventions (ie, surgery and/or radiation).

          -  In addition to neurosurgery to treat CNS metastases, adjuvant radiation after the
             resection of CNS metastasis is allowed. Immunosuppressive doses of systemic steroids
             (doses ≥ 10 mg/day prednisone or equivalent) must be discontinued at least 14 days
             before study drug administration.

          -  Prior surgery that required general anesthesia must be completed at least 4 weeks
             before study drug administration. Surgery requiring local/epidural anesthesia must be
             completed at least 72 hours before study drug administration.

          -  All baseline laboratory requirements will be assessed and should be obtained within 14
             days of first dose of study drug. Screening laboratory values must meet the following
             criteria:

          -  White blood cells ≥ 2000/µL

          -  Neutrophils ≥ 1500/µL

          -  Platelets ≥ 100 × 10³/µL

          -  Hemoglobin ≥ 9.0 g/dL

          -  Serum creatinine ≤ 1.5 × upper limit of normal (ULN) or creatinine clearance > 40
             mL/minute (using Cockcroft/Gault formula)

          -  Patient Re-enrollment: This study permits the re-enrollment of a patient that has
             discontinued the study as a screen failure (ie, patient has not been dosed/has not
             been treated). If re-enrolled, the patient must be re-consented.

          -  Males and females ≥ 18 years of age.

          -  Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy
             test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin
             hormone) within 24 hours prior to the start of study drug.; Women must not be
             breastfeeding.

          -  Women of childbearing potential must agree to follow instructions for method(s) of
             contraception for the duration of treatment with study drug(s) plus 5 half-lives of
             study drug plus 30 days (duration of ovulatory cycle). The half-lives of nivolumab and
             ipilimumab is up to 25 days and 18 days, respectively. Given the blinded nature of
             this study, WOCBP should therefore use an adequate method to avoid pregnancy for a
             total of 23 weeks posttreatment completion.

          -  Males who are sexually active with WOCBP must agree to follow instructions for
             method(s) of contraception for the duration of treatment with study drug(s) plus 5
             half lives of the study drug(s) plus 90 days (duration of sperm turnover). The
             half-lives of nivolumab and ipilimumab are up to 25 days and 18 days, respectively.
             Given the blinded nature of this study, men should therefore use an adequate method of
             contraception for a total of 31 weeks posttreatment completion.

          -  Azoospermic males and WOCBP who are continuously not heterosexually active are exempt
             from contraceptive requirements. However, they must still undergo pregnancy testing as
             described in this section.

        Exclusion Criteria:

          -  Patients with carcinomatosis meningitis or a history of ocular/uveal melanoma are
             excluded.

          -  Patients with previous nonmelanoma malignancies are excluded unless a complete
             resection or remission was achieved at least 2 years prior to study entry and no
             additional therapy is required or anticipated to be required during the study period
             (exceptions include, but are not limited to, nonmelanoma skin cancers, in situ bladder
             cancer, in situ gastric cancer or gastrointestinal stromal tumor, in situ colon
             cancers, in situ cervical cancers/dysplasia, or breast carcinoma in situ).

          -  Patients with active, known, or suspected autoimmune disease. Patients with type I
             diabetes mellitus, residual hypothyroidism due to autoimmune thyroiditis only
             requiring hormone replacement, or skin disorders (such as vitiligo, psoriasis, or
             alopecia) not requiring systemic treatment are permitted to enroll. For any cases of
             uncertainty, it is recommended that the Principal Investigator be consulted prior to
             signing informed consent.

          -  Patients with a condition requiring systemic treatment with either corticosteroids (≥
             10 mg daily prednisone or equivalent) or other immunosuppressive medications within 14
             days of study drug administration. Inhaled or topical steroids are permitted in the
             absence of active autoimmune disease.

          -  Prior therapy for melanoma with the following exceptions which are allowed: 1) surgery
             for the melanoma lesion(s), 2) adjuvant RT after neurosurgical resection for CNS
             lesions, and 3) prior adjuvant IFN (see qualifier below). Specifically, patients who
             received prior therapy with anti-PD-1, anti PD L1, anti-PD-L2, anti-CD137, or
             anti-CTLA-4 antibody (including ipilimumab or any other antibody or drug specifically
             targeting T cell costimulation or checkpoint pathways) are not eligible. • Prior
             treatment with adjuvant IFN is allowed if completed ≥ 3 months prior to treatment.

          -  Treatment directed against the melanoma (eg, chemotherapy, targeted agents,
             biotherapy, limb perfusion) that is administered after a prior complete resection
             other than adjuvant radiation after neurosurgical resection and IFN for resected
             melanoma.

          -  Previous therapy with histone deacetylase inhibitor.

          -  Any of the following laboratory abnormalities:

          -  ANC < 1,500/µL

          -  Platelet count < 100,000/µL

          -  Hematologic growth factors are not allowed at screening or during the first cycle of
             treatment

          -  Hemoglobin < 9 g/dL (< 5.5 mmol/L; previous red blood cell transfusion is permitted)

          -  Creatinine > 1.5 × ULN

          -  AST or ALT > 2.5 × ULN. For patients with liver metastasis, AST or ALT > 5 × ULN

          -  Serum total bilirubin > 1.5 mg/dL or > 3 × ULN for patients with hereditary benign
             hyperbilirubinemia

          -  Corrected QT interval (QTc) using Fridericia's formula value > 480 msec at screening;
             family or personal history of long QTc syndrome or ventricular arrhythmias including
             ventricular bigeminy at screening; previous history of drug induced QTc prolongation
             or the need for treatment with medications known or suspected of producing prolonged
             QTc intervals on electrocardiogram (ECG).

          -  Congestive heart failure (New York Heart Association Class III or IV), myocardial
             infarction within 12 months before starting study treatment, or unstable or poorly
             controlled angina pectoris, including Prinzmetal variant angina pectoris.

          -  Any serious or uncontrolled medical disorder or active infection that, in the opinion
             of the Investigator, may increase the risk associated with study participation, study
             drug administration, or would impair the ability of the patient to receive protocol
             therapy.

          -  Any positive test result for hepatitis B virus or hepatitis C virus indicating acute
             or chronic infection.

          -  Known history of testing positive for human immunodeficiency virus or known acquired
             immunodeficiency syndrome.

          -  History of Grade ≥ 3 allergy to human monoclonal antibodies.

          -  Prisoners or patients who are involuntarily incarcerated.

          -  Patients who are compulsorily detained for treatment of either a psychiatric or
             physical (eg, infectious disease) illness.

          -  Pregnant or nursing women.

          -  Psychological, familial, sociological, or geographical conditions that potentially
             hamper compliance with the study protocol and follow-up schedule; those conditions
             should be discussed with the patient before registration in the trial.