Inclusion Criteria:

          -  Diagnosis of histologically confirmed metastatic/advanced (inoperable) renal cell
             carcinoma with clear cell or non-clear cell histology.

          -  Measurable disease by RECIST 1.1

          -  Must have progressed on at least one but no more than two lines of targeted therapies
             or have increasing incidences and intolerability of ≥ Gr.2 AE (CTCAE) toxicity from
             ongoing targeted therapies. Targeted therapies that cause immediate toxicities and
             result in discontinuation of treatment within 4 weeks after the start of individual
             treatments are not considered as progression.

          -  Consented for genome sequencing and data sharing.

          -  Life expectancy of at least 12 weeks.

          -  At least 18 years of age.

          -  Karnofsky performance status ≥ 70%

          -  Normal bone marrow and organ function as defined below:

               -  Absolute neutrophil count ≥ 1,000/mcL

               -  Platelets ≥ 75,000/mcL

               -  Hemoglobin ≥ 9.0 g/dL

               -  Serum bilirubin ≤ 1.5 x institutional upper limit of normal (IULN). This does not
                  apply to patients with confirmed Gilbert's syndrome, who will be allowed in
                  consultation with their physician

               -  AST(SGOT)/ALT(SGPT) ≤ 2.5 x IULN; for patients with hepatic metastases, ALT and
                  AST ≤ 4 x IULN

               -  Measured creatinine clearance > 40 mL/min or calculated creatinine clearance > 40
                  mL/min as determined by Cockcroft-Gault using actual body weight

          -  Evidence of post-menopausal status or negative urinary or serum pregnancy test for
             female pre-menopausal patients. Women will be considered post-menopausal if they have
             been amenorrheic for 12 months without an alternative medical cause. The following
             age-specific requirements apply:

               -  Women <50 years of age would be considered post-menopausal if they have been
                  amenorrheic for 12 months or more following cessation of exogenous hormonal
                  treatments and if they have luteinizing hormone and follicle-stimulating hormone
                  levels in the post-menopausal range for the institution or underwent surgical
                  sterilization (bilateral oophorectomy or hysterectomy).

               -  Women ≥50 years of age would be considered post-menopausal if they have been
                  amenorrheic for 12 months or more following cessation of all exogenous hormonal
                  treatments, had radiation-induced menopause with last menses >1 year ago, had
                  chemotherapy-induced menopause with last menses >1 year ago, or underwent
                  surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or
                  hysterectomy).

          -  Ability to understand and willingness to sign an IRB approved written informed consent
             document (or that of legally authorized representative, if applicable).

        Exclusion Criteria:

          -  Received any immuno-oncology agents including, but not limited to, other anti CTLA-4,
             including tremelimumab anti-PD-1, anti-PD-L1 including durvalumab, and anti-programmed
             cell death ligand 2 (anti-PD-L2) antibodies, excluding therapeutic anticancer
             vaccines. Patients with prior adjuvant or neoadjuvant treatment of targeted therapies
             for RCC are eligible.

          -  A history of other malignancy ≤ 2 years previous with the exception of basal cell or
             squamous cell carcinoma of the skin which were treated with local resection only or
             carcinoma in situ of the cervix.

          -  Currently receiving any other investigational agents.

          -  Spinal cord compression or clinically active central nervous system metastasis,
             defined as untreated and symptomatic, or requiring therapy with corticosteroids.
             Subjects with treated brain metastasis that are no longer symptomatic may be included.
             A minimum of 2 weeks must have elapsed between the end of radiation and the study
             enrollment.

          -  A history of allergic reactions attributed to compounds of similar chemical or
             biologic composition to durvalumab, tremelimumab, vaccines, or other agents used in
             the study.

          -  Receipt of live attenuated vaccine within 30 days prior to the first dose of study
             treatment.

          -  Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the
             exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
             criteria -Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis
             after consultation with the Study Physician.

          -  Patients with irreversible toxicity not reasonably expected to be exacerbated by
             treatment with durvalumab or tremelimumab may be included only after consultation with
             the Study Physician.

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
             angina pectoris, cardiac arrhythmia, interstitial lung disease, or serious chronic
             gastrointestinal conditions associated with diarrhea.

          -  Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥470 ms
             calculated from 3 ECGs (within 15 minutes at 5 minutes apart).

          -  History of leptomeningeal carcinomatosis.

          -  History of syncopal or vasovagal episode as determined by medial record and history in
             the 6-month period prior to first vaccination administration.

          -  Individuals in whom a skinfold measurement of the cutaneous and subcutaneous tissue
             for eligible injection sites (left and right medial deltoid region) exceeds 40 mm.

          -  Individuals in whom the ability to observe possible local reactions at the eligible
             injection sites (deltoid region) is, in the opinion of the investigator, unacceptably
             obscured due to a physical condition or permanent body art.

          -  Therapeutic or traumatic metal implant in the skin or muscle of either deltoid region.

          -  Any current chronic or active neurologic disorder, including seizures and epilepsy,
             requires active medical management.

          -  Current use of any electronic stimulation device, such as cardiac demand pacemakers,
             automatic implantable cardiac defibrillator, nerve stimulators, or deep brain
             stimulators.

          -  Major surgical procedure (as defined by the PI) within 28 days prior to the first dose
             of durvalumab and tremelimumab. Note: Local surgery of isolated lesions for palliative
             intent is acceptable.

          -  History of allogenic organ transplantation.

          -  Active or prior documented autoimmune or inflammatory disorders (including
             inflammatory bowel disease [eg, colitis or Crohn's disease], diverticulitis [with the
             exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or
             Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid
             arthritis, hypophysitis, uveitis, etc]). The following are exceptions to this
             criterion:

               -  Patients with vitiligo or alopecia

               -  Patients with hypothyroidism (eg, following Hashimoto syndrome) stable on hormone
                  replacement

               -  Any chronic skin condition that does not require systemic therapy

               -  Patients without active disease in the last 5 years may be included but only
                  after consultation with the study physician

               -  Patients with celiac disease controlled by diet alone

          -  History of active primary immunodeficiency

          -  Active infection including tuberculosis (clinical evaluation that includes clinical
             history, physical examination and radiographic findings, and tuberculosis testing in
             line with local practice), hepatitis B (known positive HBV surface antigen (HBsAg)
             result), hepatitis C, or human immunodeficiency virus (positive HIV 1/2 antibodies).
             Patients with a past or resolved HBV infection (defined as the presence of hepatitis B
             core antibody [anti-HBc] and absence of HBsAg) are eligible. Patients positive for
             hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative
             for HCV RNA.

          -  Current or prior use of immunosuppressive medication within 14 days before the first
             dose of durvalumab or tremelimumab. The following are exceptions to this criterion:

               -  Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra
                  articular injection)

               -  Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
                  prednisone or its equivalent

               -  Steroids as premedication for hypersensitivity reactions (eg, CT scan
                  premedication)

          -  Pregnant and/or breastfeeding. Women of childbearing potential must have a negative
             serum/urine pregnancy test within 14 days of study entry. All patients must be willing
             to employ effective birth control from screening to 90 days after the last dose of
             durvalumab monotherapy or 180 days after the last dose of durvalumab + tremelimumab
             combination therapy.

          -  Known HIV-positive status. These patients are ineligible because of the potential
             inability to generate an immune response to vaccines.