Inclusion Criteria:

          1. The subject with disease that is not amendable to a curative treatment approach or
             locally advanced or metastatic or unresectable CCC with histological diagnosis

          2. At least one measurable(per RECIST 1.1) lesion

          3. Primary or metastatic tumor with HER2 positive defined on IHC2+, FISH+ or IHC3+

          4. ECOG Performance status 0 or 1

          5. At least 3 months for life expectancy Common inclusion criteria

          6. Men or women over 19 years at time of signing ICF

          7. Signed Informed Consent Form

             Exclusion Criteria:

          8. Received prior chemotherapy for advanced/metastatic disease (the adjuvant/neoadjuvant
             chemotherapy completed at least 6 months before enrolled will be accepted)

          9. Not recovery from toxicities related to any prior treatments excluding alopecia (eg,
             neurological toxicity to ≥ Grade 2)

         10. History of malignancy other than CCC within 5 years prior to screening, with the
             exception of malignancies with a negligible risk of metastasis or death, such as
             carcinoma in situ or thyroid papillary carcinoma Hematology, chemistry or organ
             function

         11. ANC < 1.5 × 109/L, or Platelet < 100 × 109/L

         12. Total bilirubin > 1.5 × ULN; or AST/ ALT > 2.5 × ULN (or if the tumor has expanded
             into the liver, > 5 × ULN); or, alkaline phosphatase > 2.5 × ULN (or > 5 × if the
             tumor has expanded into the liver, or > 10 × ULN if the tumor has expanded into the
             brain without liver,); or albumin < 2.5 g/dL

         13. Creatinine clearance < 60 mL/min(calculated using the Cockcroft-Gault formula) Other
             exclusion criteria related to IP

         14. History of proved congestive heart failure; angina with medication; evidence of
             transmural myocardial infarction on ECG; uncontrolled hypertension(systolic> 180 mmHg
             or diastolic> 100 mmHg); clinically significant heart valve disease; uncontrolled
             arrhythmia

         15. LVEF < 50% (calculated by cardiac sonography or MUGA)

         16. Subject with rest dyspnea due to metastatic tumor or other disease or who needs oxygen
             therapy

         17. Chronic or high-dose corticosteroid treatment

         18. Clinically significant Hearing impairment Common exclusion criteria

         19. History or evidence of CNS metastases

         20. Interstitial pneumonia or pulmonary fibrosis with symptom and exact lesion on chest
             X-ray

         21. Hearing loss

         22. Uncontrolled significant systemic disease (eg, infection or uncontrolled DM)

         23. Pregnant or lactating females

         24. Sexually active fertile subjects without contraception

         25. Treatment with other investigational therapy within 4 weeks prior to initiation of
             study treatment

         26. Radiotherapy within 4 weeks prior to initiation of study treatment (the rest at least
             2 weeks after palliative radiotherapy for bone metastasis and recovery from the
             effects of radiation will be accepted.)

         27. Major surgery within 4 weeks prior to initiation of study treatment

         28. History of HIV and active HBV or HCV

         29. Previously identified allergy or hypersensitivity to components of the study treatment
             formulations