Inclusion Criteria:

        In order to be eligible to participate in this study, an individual must meet all of the
        following criteria:

          1. Provision to sign and date the consent form.

          2. Stated willingness to comply with all study procedures and be available for the
             duration of the study.

          3. Be a female aged 18-89.

          4. Patients with a primary Stage III/IV or recurrent endometrial cancer.

          5. Patients have received at least one prior chemotherapy regimen and no more than two
             prior cytotoxic regimens (including hormonal therapy).

          6. Primary chemotherapy regimen must have consisted of at least 4 completed cycles and no
             more than 8 completed cycles.

          7. Previous cytotoxic regimen at least 4 weeks before initiation and no more than 8 weeks
             from initiation after last dose of previous therapy.

          8. Patients who receive radiation to the whole pelvis or at least 50% of the spine must
             complete radiation therapy and have at least 4 weeks' time elapse prior to initiation
             of drug.

          9. ECOG performance status of 0, 1 or 2.

         10. ANC > or = 1500 cells/microliters

         11. Platelet count > 100,000 microliters

         12. Hemoglobin > or = 9.0 g/dL

         13. Serum albumin > or = 2.5 g/dL

         14. Total bilirubin ≤ 1.5 x ULN

         15. AST and ALT ≤ 3.0 x ULN

         16. Serum Creatinine ≤ 1.5x ULN

        Exclusion Criteria:

        An individual who meets any of the following criteria will be excluded from participation
        in this study:

          1. Inability to comply with study and follow-up procedures

          2. Significant cardiovascular disease, such as New York Heart Association cardiac disease
             (Class II or greater), myocardial infarction within the past 3 months, unstable
             arrhythmias, or unstable angina

          3. Known clinically significant liver disease defined as AST and ALT > 3.0 x ULN and/or
             Total bilirubin > or = 1.5 x ULN, or documented history of active viral, alcoholic, or
             other hepatitis, cirrhosis, and inherited liver disease

          4. Participation in investigational clinical trial within last 30 days

          5. History of significant chronic disease including HIV/AIDS or hepatitis C

          6. Inability to provide informed consent

          7. Known CNS malignancy or CNS metastases

          8. Patients with previous malignancy, other than endometrial, within the past 2 years
             from cycle 1, day 1, with the exception of those with negligible risk of metastasis or
             death, such as adequately controlled basal cell carcinoma or squamous cell carcinoma
             of the skin or carcinoma in situ of the breast.

          9. History of stroke or transient ischemic attack (TIA) within 3 months prior to cycle 1
             day 1(C1D1)

         10. Women with prognosis for survival less than 6 months

         11. Patients who have progressed or have stable disease (SD) through most recent
             chemotherapy regimen

         12. Patients deemed otherwise clinically unfit for clinical trial per Investigator's
             discretion

         13. Patients with duodenal stent or other GI disorder/defect that would interfere with
             absorption of oral medication

         14. Female patients who maintain fertility potential and refuse to comply to use
             contraception and be followed for pregnancy by pregnancy testing

         15. Minor surgical procedure < or = 14 days or major surgeries < or = 28 days prior to
             first dose of treatment