Inclusion Criteria:

          -  Adult patients with intermediate or high-risk smoldering multiple myeloma (SMM) are
             eligible

          -  Patients must have histologically confirmed SMM based on the following criteria. Both
             criteria must be met: (a) Serum monoclonal protein (IgG or IgA) >= 3 g/dL or urinary
             monoclonal protein >=500 mg per 24 hours and/or clonal bone marrow plasma cells more
             or equal to 10% (b) Absence of myeloma defining events or amyloidosis

          -  Additionally, patients must meet criteria for intermediate or high risk of progression
             to multiple myeloma by Programa para el Estudio de la Terapeutica en Hemopatía Maligna
             (PETHEMA) criteria (patients must have at least 1 risk factors present):

               -  >= 95% abnormal plasma cells/total plasma cells in bone marrow compartment. (This
                  is measured as a percentage of the total abnormal versus normal plasma cells in
                  the bone marrow compartment using standard flow cytometry of the bone marrow
                  aspirate. Having >= 95% abnormal plasma cells/total plasma cells constitutes a
                  risk factor for progression to multiple myeloma by PETHEMA criteria)

               -  Immunoparesis (The patient having low uninvolved immunoglobulins in peripheral
                  blood, for example if a patient has IgA smoldering multiple myeloma, then either
                  having a low IgM and/or low IgG will qualify as a risk factor for progression to
                  multiple myeloma) *1 of 2 risk factors: intermediate risk for progression at a
                  rate of ~50% at 5 years *2 of 2 risk factors: high risk for progression at a rate
                  of 72% at 5 years

          -  Creatinine clearance >= 40 ml/min using the modification of diet in renal disease
             (MDRD) equation

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-2

          -  Absolute neutrophil count (ANC) >= 1.0 x 10^9/L

          -  Hemoglobin >= 10 g/dL

          -  Platelet count >= 50 x 10^9/L

          -  Platelet and blood transfusions are allowed on protocol. Growth factors, including
             granulocyte colony stimulating factors and erythropoietin are allowed

          -  Bilirubin < 1.5 x the upper limit of normal (ULN)

          -  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.0 x ULN

          -  Subjects must be able to give informed consent

        Exclusion Criteria:

          -  Evidence of myeloma defining events due to underlying plasma cell proliferative
             disorder meeting at least one of the following

               -  Hypercalcemia: serum calcium > 0.25 mmol/L (> 1 mg/dL) higher than the upper
                  limit of normal or > 2.75 mmol/L (> 11 mg/dL)

               -  Renal Insufficiency: creatinine clearance < 40 ml/min or serum creatinine > 2
                  mg/dL

               -  Anemia: hemoglobin value < 10 g/dL

               -  Bone lesions: one or more osteolytic lesions on skeletal radiography,
                  computerized tomography (CT) or 2-deoxy-2[F-18] fluoro-D-glucose positron
                  emission tomography CT (PET-CT)

          -  Prior or concurrent systemic treatment for SMM

               -  Bisphosphonates are permitted

               -  Treatment with corticosteroids is not permitted (allowed for physiologic doses)

               -  Radiotherapy is not permitted

               -  Prior treatment for smoldering multiple myeloma with chemotherapy agents approved
                  for the treatment of multiple myeloma is not permitted

          -  Plasma cell leukemia

          -  Pregnant or lactating females

          -  Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
             other form of immunosuppressive therapy within 7 days prior to the first dose of trial
             treatment

          -  Has a known history of active TB (Bacillus tuberculosis)

          -  Has a known additional malignancy that is progressing or requires active treatment.
             Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the
             skin that has undergone potentially curative therapy or in situ cervical cancer

          -  Has an active infection requiring systemic therapy

          -  Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the trial, interfere with the subject's
             participation for the full duration of the trial, or is not in the best interest of
             the subject to participate, in the opinion of the treating investigator

          -  Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial

          -  Is pregnant or breastfeeding, or expecting to conceive or father children within the
             projected duration of the trial, starting with the pre-screening or screening visit
             through 60 days after the last dose of trial treatment

          -  Has a known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies)

          -  Has known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or
             hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [RNA] [qualitative] is
             detected)