Clinical Trials /

Second-line Study of PEGPH20 and Pembro for HA High Metastatic PDAC

NCT03634332

Description:

This study is the study of the combination of PEGPH20 and Pembrolizumab (MK-3475) for patients with previously treated Hyaluronan High (HA-high) metastatic pancreatic ductal adenocarcinoma. This study is an interventional, unblinded, open label study. Approximately 35 subjects will be enrolled. The trial will require approximately a total of 18 months, including 12 months for enrollment, with an additional 6 months for patient follow-up, data collection and study closure. Each subject will participate in the trial from the time the subject signs the Informed Consent Form (ICF) through the final contact. After a screening phase of up to 21 days, eligible subjects will receive PEGPH20 beginning with Cycle 1 Day 1, on Days 1, 8 15 of every 3 week-cycles and pembrolizumab beginning on Cycle 1 Day 1 (2-4 hrs after PEGPH20), every 3-week-cycles. Treatment with PEGPH20 and pembrolizumab will continue until progressive disease (PD), unacceptable adverse events (AEs), intercurrent illness that prevents further administration of treatment, investigator's decision to withdraw the subject, subject withdraws consent, pregnancy of the subject, noncompliance with trial treatment or procedure requirements, subject receives 35 treatments (approximately 24 months) of pembrolizumab, or administrative reasons requiring cessation of treatment. Subjects who discontinue for reasons other than PD will have post-treatment follow-up for disease status until PD, initiating a non-study cancer treatment, withdrawing consent, or becoming lost to follow-up. All subjects will be followed by telephone for overall survival (OS) until death, withdrawal of consent, or the end of the study. After the end of treatment, each subject will be followed for 30 days for AE monitoring. Serious adverse events (SAE) and events of clinical interest (ECI) will be collected for 90 days after the end of treatment or for 30 days after the end of treatment if the subject initiates new anticancer therapy, whichever is earlier.

Related Conditions:
  • Pancreatic Ductal Adenocarcinoma
Recruiting Status:

Recruiting

Phase:

Phase 2

Trial Eligibility

Document

Title

  • Brief Title: Second-line Study of PEGPH20 and Pembro for HA High Metastatic PDAC
  • Official Title: Phase II Study of PEGPH20 and Pembrolizumab (MK-3475) for Patients With Previously Treated Hyaluronan High (HA-High) Metastatic Pancreatic Ductal Adenocarcinoma

Clinical Trial IDs

  • ORG STUDY ID: PCRT 16-001
  • NCT ID: NCT03634332

Conditions

  • Pancreatic Ductal Adenocarcinoma
  • Pancreatic Cancer
  • Pancreatic Neoplasms

Interventions

DrugSynonymsArms
PEGPH20PEGPH20 plus Pembrolizumab
PembrolizumabKeytruda, MK-3475PEGPH20 plus Pembrolizumab

Purpose

This study is the study of the combination of PEGPH20 and Pembrolizumab (MK-3475) for patients with previously treated Hyaluronan High (HA-high) metastatic pancreatic ductal adenocarcinoma. This study is an interventional, unblinded, open label study. Approximately 35 subjects will be enrolled. The trial will require approximately a total of 18 months, including 12 months for enrollment, with an additional 6 months for patient follow-up, data collection and study closure. Each subject will participate in the trial from the time the subject signs the Informed Consent Form (ICF) through the final contact. After a screening phase of up to 21 days, eligible subjects will receive PEGPH20 beginning with Cycle 1 Day 1, on Days 1, 8 15 of every 3 week-cycles and pembrolizumab beginning on Cycle 1 Day 1 (2-4 hrs after PEGPH20), every 3-week-cycles. Treatment with PEGPH20 and pembrolizumab will continue until progressive disease (PD), unacceptable adverse events (AEs), intercurrent illness that prevents further administration of treatment, investigator's decision to withdraw the subject, subject withdraws consent, pregnancy of the subject, noncompliance with trial treatment or procedure requirements, subject receives 35 treatments (approximately 24 months) of pembrolizumab, or administrative reasons requiring cessation of treatment. Subjects who discontinue for reasons other than PD will have post-treatment follow-up for disease status until PD, initiating a non-study cancer treatment, withdrawing consent, or becoming lost to follow-up. All subjects will be followed by telephone for overall survival (OS) until death, withdrawal of consent, or the end of the study. After the end of treatment, each subject will be followed for 30 days for AE monitoring. Serious adverse events (SAE) and events of clinical interest (ECI) will be collected for 90 days after the end of treatment or for 30 days after the end of treatment if the subject initiates new anticancer therapy, whichever is earlier.

Detailed Description

      Combination strategies geared towards blocking the PD1/PD-L1 inhibitory pathway, such as with
      pembrolizumab, concurrent with stroma depletion (PEGPH20) may induce synergistic anti-cancer
      activity and immune responses in pancreatic cancer. Effective harnessing of the immune system
      and rational combinations with stroma-targeting biological agents (PEGPH20) is a novel field
      that needs to be explored in pancreatic cancer. This phase II trial will determine the
      efficacy of pembrolizumab plus PEGPH20 in metastatic pancreatic cancer patients who have
      HA-high tumor expression. Stroma and immune-related biomarkers will be tested prospectively
      in blood and tumor biopsies at baseline, after 6 weeks of therapy, and at time of cancer
      progression. A phase I study with pembrolizumab and PEGPH20 is ongoing in lung and gastric
      cancer patients (NCT02563548), and demonstrated safety and tolerability of this combination
      at the doses administered in this study (Halozyme data).

      Immunotherapies have the potential to induce durable therapeutic responses although this
      typically occurs in a small fraction of patients. Biomarker-guided patient selection can, in
      principle, identify those patients most likely to benefit. The investigators hypothesize that
      stroma remodeling with PEGPH20 will potentiate effector CD8 T cell lymphocyte infiltration
      and sensitize pancreatic cancer to immune therapy, and that immunologic, and/or genomic
      biomarkers will identify patient subsets most likely to benefit. As examples, MSI-high status
      and high tumor mutational burden (hypermutation) have been linked to sensitivity to immune
      checkpoint inhibitors (Le et al. 2015, Le et al. 2016).

      Assays may include but are not limited to: Immunohistochemical analysis, profiling of the
      immune transcriptome, circulating cytokine analyses, flow cytometric analyses of peripheral
      and intratumoral immune response.

      This is an open label non-randomized Phase II trial for patients with previously treated
      metastatic ductal pancreatic adenocarcinoma with HA-high expression, to assess the
      progression-free survival rate (PFS) of patients treated with this combination therapy.
      Secondary endpoints will assess safety and tolerability, overall response rate (ORR), disease
      control rate (DCR= CR+PR+SD), duration of response and stable disease (DOR), and overall
      survival (OS).

      There will be an estimated 35 patients enrolled into the study, using 5 centers in the U.S.

      Overall response rates as well as individual categories of response (CR, PR, SD, and PD) will
      be determined using RECIST 1.1. Time-to-event endpoints, including PFS and OS will be
      assessed using the Kaplan-Meier method. Toxicity (adverse events) will be recorded using the
      NCI CTCAE, version 5.0 (published Nov 2017, Appendix B).

      All patients will start treatment with PEGPH20 3 microgram/kg IV weekly x 3, and
      pembrolizumab 200 mg IV every 3 weeks, in 3-week cycles.

      Patients may remain on treatment with PEGPH20 in combination with pembrolizumab as long as
      they are receiving clinical benefit, until disease progression per RECIST 1.1 criteria, or
      until untolerable toxicity develops, whichever comes first. If no disease progression,
      patients will be allowed to remain on study treatment for up to 24 months. If no disease
      progression, but with unacceptable toxicity from PEGPH20, patients will be allowed to
      continue on pembrolizumab alone for up to 24 months if deemed appropriate by the
      investigator. If pembrolizumab needs to be discontinued for toxicity, patients may continue
      treatment with PEGPH20 alone.

      The estimated duration for accrual is anticipated to be 12 months. Patients will be followed
      up for a minimum of 6 months. The overall study duration is estimated at approximately 18
      months.
    

Trial Arms

NameTypeDescriptionInterventions
PEGPH20 plus PembrolizumabExperimentalAll patients will receive treatment with PEGPH20 3 micrograms/kg IV weekly x 3, and pembrolizumab 200 mg IV every 3 weeks, in 3-week cycles.
  • PEGPH20

Eligibility Criteria

        Inclusion Criteria:

          1. Be willing and able to provide written informed consent/assent for the trial.

          2. Histologically confirmed metastatic pancreatic ductal adenocarcinoma, via archived or
             fresh core biopsy of either primary tumor or metastatic site.

          3. Available tumor tissue (formalin-fixed paraffin-embedded [FFPE] block preferred) with
             enough tumor to make a minimum of 5-10 unstained, consecutive FFPE slides (10 slides
             are preferred) of 1 archival block that meets specific tissue sample requirements.
             Archived or fresh tissue from the primary lesion or a metastatic lesion is required.
             Note: Fine needle aspirates or brushing biopsies will not be acceptable. This tumor
             tissue requirement is for the determination of the HA-high or -low expression status.

          4. Subjects must be determined to be HA-high based on archival or fresh tumor biopsy that
             meets the requirements noted in the previous inclusion criterion.

          5. 18 years of age on day of signing informed consent.

          6. Have measurable metastatic disease based on RECIST 1.1.

          7. Life expectancy ≥ 12 weeks.

          8. Have a performance status of 0 or 1 on the ECOG Performance Scale.

          9. Received no more than 2 prior lines of systemic therapy for metastatic disease (1 or 2
             prior lines of therapy for metastatic disease are allowed)

         10. Be willing to provide tumor tissue from newly obtained tumor cores or excisional
             biopsy for research purposes. Newly-obtained is defined as a specimen obtained within
             2 weeks (14 days) prior to initiation of treatment on Day 1.

         11. Be willing to provide tumor tissue from tumor biopsy after 6 weeks of treatment
             (mandatory, if safe and feasible), and at the time of tumor progression (optional, if
             safe and feasible). Note: Fine needle aspirates or brushing biopsies will not be
             acceptable.

         12. Demonstrate adequate organ function, all screening labs should be performed within 14
             days of treatment initiation.

         13. Female subjects of childbearing potential should have a negative urine or serum
             pregnancy within 72 hours prior to receiving the first dose of study medication. If
             the urine test is positive or cannot be confirmed as negative, a serum pregnancy test
             will be required.

         14. Female subjects of childbearing potential must be willing to use an adequate method of
             contraception for the course of the study through 120 days after the last dose of
             study medication.

             Note: Abstinence is acceptable if this is the usual lifestyle and preferred
             contraception for the subject.

         15. Male subjects of childbearing potential must agree to use an adequate method of
             contraception starting with the first dose of study therapy through 120 days after the
             last dose of study therapy.

             Note: Abstinence is acceptable if this is the usual lifestyle and preferred
             contraception for the subject.

         16. No history of acute DVT/PE or CVA/TIA (new within 4 weeks of study registration) or
             clinical significant carotid artery disease.

         17. If prior history of DVT/PE the patient needs to be on stable doses of anticoagulation
             with low molecular weight heparins.

               -  Patients should have all eligibility criteria met, before undergoing the baseline
                  research biopsy.

        Exclusion Criteria:

          1. Is currently participating and receiving study therapy or has participated in a study
             of an investigational agent and received study therapy or used an investigational
             device within 2 weeks of the first dose of treatment.

          2. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy
             (equivalent of > 20 mg of hydrocortisone per day) or any other form of
             immunosuppressive therapy within 7 days prior to the first dose of trial treatment.

          3. Has a known history of active tuberculosis (TB).

          4. Hypersensitivity to pembrolizumab or any of its excipients.

          5. Known allergy to PEGPH20 (hyaluronidase).

          6. Current use of megestrol acetate (use within 10 days of Day 1).

          7. Contraindication to heparin as per institutional guidelines.

          8. Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study
             Day 1 or who has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events
             due to agents administered more than 2 weeks earlier.

          9. Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy
             within 2 weeks prior to study Day 1 or who has not recovered (i.e., ≤ Grade 1 or at
             baseline) from adverse events due to a previously administered agent.

               -  Note: Subjects with ≤ Grade 2 neuropathy are an exception to this criterion and
                  may qualify for the study.

               -  Note: If subject received major surgery, they must have recovered adequately from
                  the toxicity and/or complications from the intervention prior to starting
                  therapy.

         10. Has a known additional malignancy that is progressing or requires active treatment.
             Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the
             skin that has undergone potentially curative therapy or in situ cervical cancer.

         11. Has known active central nervous system (CNS) metastases and/or carcinomatous
             meningitis. Subjects with previously treated brain metastases may participate provided
             they are stable (without evidence of progression by imaging for at least four weeks
             prior to the first dose of trial treatment and any neurologic symptoms have returned
             to baseline), have no evidence of new or enlarging brain metastases, and are not using
             steroids for at least 7 days prior to trial treatment. This exception does not include
             carcinomatous meningitis which is excluded regardless of clinical stability.

         12. Has active autoimmune disease that has required systemic treatment in the past 2 years
             (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
             drugs), or documented history of clinically severe autoimmune disease (e.g., colitis,
             Crohns' disease)*. Replacement therapy (eg, thyroxine, insulin, or physiologic
             corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is
             not considered a form of systemic treatment.

             *Any relevant diseases that are not listed as examples of exclusionary diseases are to
             be discussed with the Sponsor-Investigator.

         13. Has known history of, or any evidence of active, non-infectious pneumonitis.

         14. Has a history of (non-infectious) pneumonitis that required steroids or has current
             pneumonitis.

         15. Has known hepatobiliary diseases (e.g., primary biliary cholangitis, primary
             sclerosing cholangitis, immune mediated cholangitis); patients with cholangitis
             attributed to infectious etiology (e.g., ascending cholangitis, bacterial cholangitis)
             are eligible if the infection has been fully recovered prior to the screening visit.

         16. Has known history of drug-induced hepatobiliary toxicities

         17. Has an active infection requiring systemic therapy.

         18. Has a history or current evidence of any condition, therapy, or laboratory abnormality
             that might confound the results of the trial, interfere with the subject's
             participation for the full duration of the trial, or is not in the best interest of
             the subject to participate, in the opinion of the treating investigator.

         19. Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial.

         20. Is pregnant or breastfeeding, or expecting to conceive or father children within the
             projected duration of the trial, starting with the pre-screening or screening visit
             through 120 days after the last dose of trial treatment.

         21. Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent, or any
             other immune checkpoint inhibitors.

         22. Has received prior therapy with PEGPH20, or has participated in the Halozyme HALO 301
             phase III study.

         23. Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).

         24. Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA
             [qualitative] is detected).

         25. Has received a live vaccine within 30 days of planned start of study therapy. Note:
             Seasonal influenza vaccines for injection are generally inactivated flu vaccines and
             are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®) are live
             attenuated vaccines, and are not allowed.
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Progression Free Survival
Time Frame:PFS will be assessed from Date of registration through study closure, up to 24 months. PFS is calculated as the number of days from date of registration to date of disease progression or symptomatic deterioration, or death due to any cause.
Safety Issue:
Description:Evaluate the progression-free survival (PFS) for patients treated with pembrolizumab and PEGPH20

Secondary Outcome Measures

Measure:Number of participants with treatment-related adverse events as assessed by CTCAE v5.0
Time Frame:Safety and Tolerability using CTCAE v5.0 will be assessed from Day 1 of study treatment through 30-days past the last study treatment per patient, through study closure, up to 24 months.
Safety Issue:
Description:Evaluate the safety and tolerability of this treatment combination as assessed by CTCAE v5.0.
Measure:Overall Response Rate
Time Frame:ORR is assessed from Day 1 of treatment to study closure, up to 24 months. ORR is calculated by adding the Complete Responses (CR) with the Partial Responses (PR), based on RECIST v1.1, recorded at each disease evaluation for each patient.
Safety Issue:
Description:Evaluate the Overall Response Rate (ORR, CR + PR) based on RECIST v1.1
Measure:Disease Control Rate
Time Frame:DCR is assessed from Day 1 of treatment to study closure, up to 24 months. DCR is calculated by adding the Complete Responses, Partial Responses and Stable Disease, based on RECIST v1.1, recorded at each disease evaluation for each patient.
Safety Issue:
Description:Evaluate Disease Control Rate (DCR, CR +PR+SD)
Measure:Duration of Response
Time Frame:DOR is assessed from Day 1 of treatment to study closure, up to 24 months. DOR is calculated for patients who achieve a CR or PR, as the number of days from the date of response to the date of progression, or death, due to any cause.
Safety Issue:
Description:Evaluate the Duration of Response (DOR)
Measure:Overall Survival
Time Frame:Overall Survival is assessed from date of registration to study closure, up to 24 months. Overall Survival is calculated as the number of days from date of registration to date of death due to any cause.
Safety Issue:
Description:Evaluate the Overall Survival

Details

Phase:Phase 2
Primary Purpose:Interventional
Overall Status:Not yet recruiting
Lead Sponsor:Pancreatic Cancer Research Team

Trial Keywords

  • pancreatic
  • pancreas
  • cancer
  • adenocarcinoma

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