Inclusion Criteria:

          -  Participant (male or female) ≥18 years of age

          -  Participants who have advanced solid tumors that have failed, are intolerant to, or
             are considered ineligible for standard of care anticancer treatments including
             approved drugs for oncogenic drivers in their tumor type

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

          -  Participants in the Dose-Expansion Component must have one of the following genotypic
             aberrations: KRAS amplifications, KRASG12C (NSCLC), BRAF Class 3, or NF1 LOF (NSCLC
             and gynecological cancers) mutations

          -  Adequate hematologic, hepatic and renal function

          -  Participant able to understand and voluntarily sign the informed consent form (ICF)
             and able to comply with the study visit schedule and other protocol requirements.

          -  Participants willing to agree to not father a child/become pregnant and comply with
             effective contraception criteria

        Exclusion Criteria:

          -  Known or suspected leptomeningeal or brain metastases or spinal cord compression

          -  Primary central nervous system (CNS) tumors

          -  Clinically significant cardiac disease

          -  Active, clinically significant interstitial lung disease or pneumonitis

          -  History or current evidence of retinal pigment epithelial detachment (RPED), central
             serous retinopathy, retinal vein occlusion (RVO), or predisposing factors to RPED or
             RVO

          -  Known HIV infection

          -  Active/chronic hepatitis B or C infection

          -  Any other unstable or clinically significant concurrent medical condition that would,
             in the opinion of the investigator, jeopardize the safety of a participant, impact
             their expected survival through the end of the study participation, and/or impact
             their ability to comply with the protocol prior/concomitant therapy

          -  Females who are pregnant or breastfeeding