Inclusion Criteria:

          1. Age ≥ 15 and ≤ 26 years

          2. Histologically diagnosed EGFR positive Central Nervous System (CNS) tumor

          3. Evidence of refractory or recurrent CNS disease for which there is no standard therapy

          4. Able to tolerate apheresis or apheresis product available for use in manufacturing

          5. CNS reservoir catheter, such as an Ommaya or Rickham catheter

          6. Life expectancy ≥ 8 weeks

          7. Lansky or Karnofsky score ≥ 60

          8. If patient does not have previously obtained apheresis product, patient must have
             recovered from acute toxic effects of all prior chemotherapy, immunotherapy, and
             radiotherapy and discontinue the following prior to enrollment:

               1. ≥ 7 days post last chemotherapy/biologic therapy administration

               2. 3 half lives or 30 days, whichever is shorter post last dose of anti-tumor
                  antibody therapy

               3. Must be at least 30 days from most recent cellular infusion

               4. All systemically administered corticosteroid treatment therapy must be stable or
                  decreasing within 1 week prior to enrollment with maximum dexamethasone dose of
                  2.5 mg/m2/day. Corticosteroid physiologic replacement therapy is allowed.

          9. Adequate organ function

         10. Adequate laboratory values

         11. Subjects of childbearing/fathering potential must agree to use highly effective
             contraception

        Exclusion Criteria:

          1. Diagnosis of classic diffuse intrinsic pontine glioma (DIPG)

          2. Presence of ≥ Grade 3 cardiac dysfunction or symptomatic arrhythmia requiring
             intervention

          3. Presence of primary immunodeficiency/bone marrow failure syndrome

          4. Presence of clinical and/or radiographic evidence of impending herniation

          5. Presence of active malignancy other than the primary CNS tumor under study

          6. Presence of active severe infection

          7. Receiving any anti-cancer agents or chemotherapy

          8. Pregnant or breastfeeding

          9. Subject and/or authorized legal representative unwilling to provide consent/assent for
             participation in the 15 year follow up period

         10. Presence of any condition that, in the opinion of the investigator, would prohibit the
             patient from undergoing treatment under this protocol