Inclusion Criteria:

          -  Patient -

               1. Is able to understand and voluntarily sign a written informed consent and is
                  willing and able to comply with the protocol requirements including scheduled
                  visits, treatment plan, laboratory tests and other study procedures.

               2. Is aged ≥ 18 years

               3. Has pathologically confirmed advanced or metastatic malignancy characterized by
                  one or more of the following:

                    1. Patient is intolerant of existing therapy(ies) known to provide clinical
                       benefit for their condition

                    2. Malignancy is refractory to existing therapy(ies) known to potentially
                       provide clinical benefit

                    3. Malignancy has relapsed after standard therapy

                    4. Malignancy for which there is no standard therapy that improves survival by
                       at least 3 months

               4. Has evaluable tumor(s) by standard radiological and/or laboratory assessments as
                  applicable to their malignancy - in Part 3, patients with solid tumors must have
                  least 1 measurable lesion per response evaluation criteria in solid tumors
                  (RECIST) v1.1 criteria, measured preferably by computed tomography (CT) scan or
                  magnetic resonance image (MRI). In the case of patients with glioblastoma
                  multiforme (GBM) or other central nervous system (CNS) tumors, the tumor must be
                  measurable, defined as a clearly enhancing tumor with at two perpendicular
                  diameters at entry equal or superior to 1cm.

               5. Has laboratory function within specified parameters (may be repeated):

                    1. Adequate bone marrow function: absolute neutrophil count (ANC) ≥ 500/mL;
                       hemoglobin ≥ 8.5 g/dL, platelets ≥ 50,000/mL

                    2. Adequate liver function: transaminases (aspartate aminotransferase/ alanine
                       aminotransferase, AST/ALT) and alkaline phosphatase ≤ 3 (≤ 5 X the upper
                       limit of normal (ULN) in the setting of liver metastasis or infiltration
                       with malignant cells) x ULN; bilirubin ≤ 1.5 x ULN

                    3. Adequate renal function: creatinine clearance ≥ 60 mL/min (Cockcroft and
                       Gault)

                    4. Adequate blood coagulation: international normalized ratio (INR) ≤ 2.3

                    5. Serum amylase and lipase ≤ 1.5 x ULN

               6. Has adequate performance status (PS): Eastern Co-operative Oncology Group (ECOG)
                  PS 0-2

               7. Has received the final dose of any of the following treatments/ procedures with
                  the specified minimum intervals before first dose of study drug (unless in the
                  opinion of the investigator and the study medical coordinator the treatments/
                  procedures will not compromise patient safety or interfere with study conduct and
                  with IDMC agreement):

                    -  Chemotherapy, immunotherapy, or systemic radiation therapy - 14 days or ≥ 5
                       half-lives (whichever is shorter)

                    -  Focal radiation therapy - 7 days

                    -  Systemic and topical corticosteroids - 7 days

                    -  Surgery with general anesthesia - 7 days

                    -  Surgery with local anesthesia - 3 days

               8. May continue endocrine therapies (e.g. for breast or prostate cancer) and/or
                  anti-human epidermal growth factor (Her2) therapies while on this study

               9. Women of childbearing potential must have a negative baseline blood or urine
                  pregnancy test within 72 hours of first study therapy. Women may be neither
                  breastfeeding nor intending to become pregnant during study participation and
                  must agree to use effective contraceptive methods (hormonal or barrier method of
                  birth control, or true abstinence) for the duration of study participation and in
                  the following 90 days after discontinuation of study treatment

              10. Male patients with partners of childbearing potential must take appropriate
                  precautions to avoid fathering a child from screening until 90 days after
                  discontinuation of study treatment and use appropriate barrier contraception or
                  true abstinence

              11. Must not be receiving any other investigational medicinal product

        Exclusion Criteria:

          -  Patient -

               1. Is pregnant or lactating

               2. Is known to be hypersensitive to any of the components of 9-ING-41 or to the
                  excipients used in its formulation

               3. Has not recovered from clinically significant toxicities as a result of prior
                  anticancer therapy, except alopecia and infertility. Recovery is defined as ≤
                  Grade 2 CTCAE Version 4.03

               4. Has significant cardiovascular impairment: history of congestive heart failure
                  greater than New York Heart Association (NYHA) Class II, unstable angina, or
                  stroke within 6 months of the first dose of 9-ING-41, or cardiac arrhythmia
                  requiring medical treatment detected at screening

               5. Has had a myocardial infarction within 12 weeks of the first dose of 9-ING-41 or
                  has electrocardiogram (ECG) abnormalities that are deemed medically relevant by
                  the investigator or study medical coordinator

               6. Has known symptomatic rapidly progressive brain metastases or leptomeningeal
                  involvement as assessed by CT scan or MRI. Patients with stable asymptomatic
                  brain metastases or leptomeningeal disease or slowly progressive disease are
                  eligible provided that they have not required new treatments for this disease in
                  a 28-day period before the first dose of study drug, and anticonvulsants and
                  steroids are at a stable dose for a period of 14 days prior to the first dose of
                  study drug

               7. Has had major surgery (not including placement of central lines) within 7 days
                  prior to study entry or is planned to have major surgery during the course of the
                  study (major surgery may be defined as any invasive operative procedure in which
                  an extensive resection is performed, e.g. a body cavity is entered, organs are
                  removed, or normal anatomy is altered. In general, if a mesenchymal barrier is
                  opened (pleural cavity, peritoneum, meninges), the surgery is considered major)

               8. Has any medical and/or social condition which, in the opinion of the investigator
                  or study medical coordinator would preclude study participation

               9. Has received an investigational anti-cancer drug in the 14-day period before the
                  first dose of study drug (or within 5 half-lives if longer) or is currently
                  participating in another interventional clinical trial

              10. Has a current active malignancy other than the target cancer

              11. Is considered to be a member of a vulnerable population (for example, prisoners)