Inclusion Criteria:

          -  Written informed consent and HIPAA authorization for release of personal health
             information. NOTE: HIPAA authorization may be included in the informed consent or
             obtained separately.

          -  Age ≥ 18 years at the time of consent.

          -  ECOG Performance Status of 0, 1 or 2.

          -  Histologically confirmed diagnosis of classical Hodgkin lymphoma that is relapsed or
             refractory - historical biopsy at last relapse is acceptable. NOTE: a repeat biopsy is
             not required if the historical biopsy was performed at the most recent relapse,
             without remission in between.

          -  Presence of radiographically measurable disease (defined as the presence one or more ≥
             1.5 cm lesions, as measured in the longest dimension by PET/CT) within 4 weeks of
             study registration.

          -  Prior therapy with check-point inhibitors (nivolumab, pembrolizumab, others) and
             subsequent progressive disease, stable disease or mixed response

          -  Failed at least 2 prior therapies including cytotoxic chemotherapy including ABVD or
             similar, autologous transplantation, brentuximab vedotin, allogenic transplantation
             without active graft versus host disease Note: Patients who are eligible and willing
             to undergo autologous transplant should not be enrolled on this trial

          -  Prior cancer treatment must be completed at least 14 days prior to registration and
             the patient must have recovered from all reversible acute toxic effects of the regimen
             (other than alopecia) to ≤Grade 1 or baseline.

          -  Absolute Neutrophil Count ≥ 1000/μL

          -  Platelets ≥ 75,000/μL (or ≥50,000/mm3 if known BM involvement)

          -  Calculated creatinine clearance ≥ 40 cc/min using the Cockcroft-Gault formula

          -  Bilirubin ≤ 1.5 x upper limit of normal (ULN)

          -  Aspartate aminotransferase (AST) ≤ 2.5 × ULN

          -  Alanine aminotransferase (ALT) ≤ 2.5 × ULN

          -  Females of childbearing potential must have a negative serum pregnancy test within 7
             days prior to registration. NOTE: Females are considered of child bearing potential
             unless they are surgically sterile (have undergone a hysterectomy, bilateral tubal
             ligation, or bilateral oophorectomy) or they are naturally postmenopausal for at least
             12 consecutive months

          -  Males who are sexually active with partners of child-bearing potential must be willing
             to abstain from heterosexual activity or adhere to contraception from the time of
             written consent until 7 months after treatment discontinuation.

          -  Patient must provide voluntary written informed consent prior to the performance of
             any research related tests or procedures.

        Exclusion Criteria:

          -  Pregnant or breastfeeding (NOTE: breast milk cannot be stored for future use while the
             mother is being treated on study).

          -  Inability or unwillingness to swallow oral medication or any condition that precludes
             the administration and/or absorption of oral medications

          -  A life-threatening illness, medical condition or organ system dysfunction, which in
             the investigator's opinion, could compromise the patient's safety, interfere with the
             metabolism of study drugs, or put the study outcomes at undue risk

          -  Active central nervous system (CNS) involvement by lymphoma

          -  Uncontrolled cardiovascular disease such as uncontrolled or symptomatic arrhythmias,
             congestive heart failure, or myocardial infarction or any class 3 or 4 cardiac disease
             as defined by the New York Heart Association Functional Classification

          -  Concomitant therapy with immunosuppressive agents, including systemic corticosteroids
             (doses ≤ 10 mg/day prednisone or equivalent are permitted).

          -  Has a history of autoimmune disease now or in past 3 years such as hepatitis,
             nephritis, hyperthyroidism, interstitial lung disease or colitis except vitiligo or
             alopecia, hypothyroidism (eg, following Hashimoto syndrome) stable on hormone
             replacement or psoriasis not requiring systemic treatment

          -  HIV-infected patients on effective anti-retroviral therapy with undetectable viral
             load within 6 months of registration are eligible for this trial.

          -  Active Hepatitis B or C infection (defined as a positive Hepatitis B surface antigen
             (Ag) or detectable viral load by PCR). NOTES: Hepatitis B and C testing is required.
             Patients with positive Hepatitis B Ag may enroll if PCR is negative. Suppressive
             antiviral therapy should be considered for these patients as clinically indicated.

          -  Currently active, clinically significant hepatic impairment Child-Pugh class B or C

          -  Currently receiving a strong CYP3A4 Inhibitor (such as but not limited to boceprevir
             clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole,
             lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir,
             saquinavir, telaprevir, telithromycin, voriconazole) or Fluconazole >200 mg/day.
             Washout period of 1 week is required.

          -  History of stroke or intracranial hemorrhage within 6 months of study registration