Inclusion Criteria:

          -  Age ≥18 years.

          -  Histologically confirmed adenocarcinoma of the prostate.

          -  Previously undergone primary therapy for prostate cancer (radical prostatectomy (RP)
             or external beam radiation (XRT) or RP + XRT). Salvage XRT following RP ≥ 6 months
             prior to registration is allowed.

          -  Rising PSA (two consecutive values ≥2.0 ng/mL above the PSA nadir taken ≥3 weeks
             apart). PSA level of 2-25 ng/mL (PSA up to 50 is allowed for patients undergoing pre-
             and on-treatment biopsies).

          -  For the biopsy sub-groups, subjects must be willing to undergo pre- and on-treatment
             biopsies.

          -  PSA Doubling Time (PSADT) ≤12 months

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-1 or Karnofsky score
             ≥70.

          -  Adequate bone marrow, hepatic, and renal function.

          -  Willingness to use barrier contraception during treatment.

          -  Willingness to provide written informed consent and HIPAA authorization.

        Exclusion Criteria:

          -  Received any experimental immunotherapy on an experimental clinical trial ≤ 1 year
             prior to registration.

          -  PSA > 25 at time of enrollment (or PSA >50 for patients receiving pre- and
             on-treatment biopsies).

          -  Other histologic types of prostate cancers such as ductal, sarcomatous, lymphoma,
             small cell, and neuroendocrine tumors

          -  Received salvage XRT ≤ 6 months prior to registration

          -  Received ADT ≤ 6 months prior to registration

          -  Received any form of chemotherapy ≤ 90 days prior to registration

          -  Received granulocyte colony-stimulating factor or granulocyte-macrophage
             colony-stimulating factor (GM-CSF) ≤ 90 days prior to registration

          -  Any major surgery requiring general anesthesia ≤ 28 days prior to registration.

          -  Any other concurrent or prior treatment for prostate cancer ≤ 28 days prior to
             registration.

          -  An active infection requiring parenteral antibiotic therapy or causing fever
             (temperature > 100.5 F or 38.1 C) within 1 week prior to registration.

          -  Prior systemic, ongoing immunosuppressive therapy ≤ 14 days prior to study treatment
             administration (except for adrenal replacement steroid doses ≤ 10mg daily prednisone
             equivalent in the absence of active autoimmune disease or a short course of steroids
             (<5 days) up to 7 days prior to initiating study treatment).

          -  Prior use of experimental agents for prostate cancer

          -  Prior participation in an anti-interleukin 8 (IL8) clinical study

          -  A candidate is scheduled or likely to be scheduled for salvage external beam XRT or
             surgery for prostate cancer during the study period

          -  Concomitant treatment with other hormonal therapy or 5α-reductase inhibitors (prior
             use of these agents is allowed if ≥3 months prior to registration).

          -  History of known or suspected autoimmune disease with the following exceptions:

               -  Asthma and/or allergic rhinitis (seasonal allergies)

               -  Vitiligo

               -  Resolved childhood atopic dermatitis

               -  Psoriasis not requiring systemic treatment, or conditions not expected to recur
                  in the absence of an external trigger.

               -  Residual hypothyroidism due to an autoimmune condition only requiring hormone
                  replacement

               -  Euthyroid participants with a history of Grave's disease (participants with
                  suspected autoimmune thyroid disorders must be negative for thyroglobulin and
                  thyroid peroxidase antibodies and thyroid stimulating immunoglobulin (Ig) prior
                  to the first dose of study treatment).

               -  Type 1 diabetes mellitus

          -  History of malignancy within the last 2 years (except non-melanoma skin cancers and
             superficial bladder cancer) and for which no additional therapy is required or
             anticipated to be required during the study period.

          -  Uncontrolled major active infectious, cardiovascular, pulmonary, hematologic, or
             psychiatric illnesses that would make the patient a poor study candidate

          -  Known prior or current history of HIV and/or hepatitis B/C

          -  Prior organ allograft