Inclusion Criteria:

          -  Performance status (ECOG) 0-2

          -  Operable histologically confirmed breast cancer

          -  Luminal B HER2-negative (ER positive, HER2 negative, and at least one of the
             following:

        Ki- 67 'high' (≥20%) or PgR 'negative or low') or Luminal B HER2-positive (ER positive,
        HER2 over-expressed or amplified, any Ki-67, any PgR)

          -  Early-stage (pT1-3; any nodal status)

          -  Candidate to adjuvant chemotherapy and endocrine therapy

          -  The tumor must be confined to the breast and axillary nodes without detected
             metastases elsewhere

          -  Patients with synchronous (diagnosed histologically within 2 months) bilateral
             invasive breast cancer are eligible if all other criteria are met

          -  Patients must have had surgery for primary breast cancer with no known clinical
             residual loco-regional disease

          -  Margins must be negative for invasive breast cancer and DCIS

          -  Patients should start treatment as close to definitive surgery as possible (no later
             than 8 weeks)

          -  No prior neoadjuvant or adjuvant therapy for breast cancer. Note: Radiotherapy is
             allowed prior to trial entry. Raloxifene, tamoxifen, or other SERM must be
             discontinued at least 4 weeks before trial entry.

          -  No hormone replacement therapy (HRT)

          -  No hormonal therapy, except steroids for adrenal failure, hormones for non-breast
             cancer related conditions (e.g., insulin for diabetes), or intermittent dexamethasone
             as an antiemetic.

          -  No treatment with bisphosphonates, except for the treatment of osteoporosis

          -  Adequate bone marrow, renal, and hepatic function must be assessed within 2 months
             before trial entry and values must meet the following criteria:

          -  WBC ≥ 3.0 x 109/L

          -  Granulocyte count ≥ 1.500 x 109/L

          -  Hemoglobin ≥ 10.0 g/dL

          -  Platelet count ≥ 100 x 109/L

          -  Serum creatinine < 1.35 mg/dl - Calculated creatinine clearance at least 50 mL/min

          -  Serum bilirubin within normal/reference range

          -  AST/ALT within 1.5 x upper normal limit

               -  Adequate cardiovascular function defined as the following must be assessed within
                  2 months before trial entry:

          -  LVEF ≥ 50% by echocardiography, radionuclide ventriculography or Multigated
             Angiography (MUGA) - No ECG evidence of acute ischemia

          -  No evidence of medically relevant conduction system abnormalities, which in the
             opinion of the investigator would preclude trial entry

          -  No myocardial infarction within the past 6 months

          -  No New York Heart Association (NYHA) class III or IV congestive heart failure

          -  Negative pregnancy test (in fertile women).

          -  Written Informed Consent (IC) must be signed and dated by the patient and the
             investigator prior to trial entry.

          -  Patients must be accessible for follow-up.

          -  Patients should have no psychiatric, addictive, or cognitive disorder that would
             prevent compliance with protocol requirements.

        Exclusion Criteria:

          -  Patients with a history of any prior ipsilateral or contralateral invasive breast
             cancer.

          -  Patients with previous or concomitant malignancy diagnosed within the past five years.
             Patients with adequately treated basal or squamous cell carcinoma of the skin, in situ
             carcinoma of the cervix or bladder, contra- or ipsilateral in situ breast carcinoma
             are eligible regardless of the date of diagnosis.

          -  Patients with other non-malignant uncontrolled systemic diseases that would preclude
             trial entry in the opinion of the investigator. Specifically not eligible are patients
             with uncontrolled active infection, chronic infection such as active HBV or HCV.

          -  Patients with myocardial infarction or pulmonary embolism within 6 months prior to
             trial entry.