The primary objective of the phase II trial is to determine the efficacy and safety of a
combination of Durvalumab with the Carboplatin/Paclitaxel as first line treatment in patients
with recurrent/metastatic SCCHN not eligible to standard chemotherapy.
For recurrent or metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN), the
standard first-line treatment is chemotherapy by cisplatin-fluorouracil and cetuximab which
allows a median overall survival of 10.1 months. Due to its toxicity, this combination could
be proposed only to patients younger than 70 years, good PS (ECOG PS0 or PS1) and adequate
renal function.
In routine practice it is estimated that the proportion of eligible patients is about two
third. One third of patients were ineligible to first-line chemotherapy by
cisplatin-fluorouracil-cetuximab. Among them, 25% due to PS2 and the others for various
reasons (older than 70 years, renal insufficiency….). For these ineligible patients, an
alternative chemotherapy should be proposed. The carboplatin-paclitaxel scheme with weekly
paclitaxel is safe for poor population and demonstrated efficacy in head and neck cancers
with overall survival varying from 4.9 months to 12.8 months in first line. The response rate
varies from 20% to 52% and is about 25% in our experience. Even for frail patients it should
be a safe and active treatment.
Nivolumab, a monoclonal antibody targeting PD1 demonstrated survival benefit compared with
chemotherapy in patients with SCCHN who progressed after platinum-based first line (median OS
of 7.5 months versus 5.1 months and 12-month OS rate of 36.0% versus 16.6%). Safety data
confirm these antibodies are of interest in a population of frail patients. Only 58.9% of
patients experienced treatment-related adverse events with nivolumab arm and 13% of grade
3/4. Durvalumab, an anti-PDL1 antibody is currently tested in SCCHN with promising results.
Head and neck cancers are rapidly progressive and due to the delayed action of immunotherapy,
and the recent demonstration that immunotherapy with anti-PD1 or anti-PDL1 can be responsible
of hyperprogression, patients will probably benefit from addition of chemotherapy to
immunotherapy, mostly for patients unfit for cisplatin-fluorouracil because their poor
condition is often related to the cancer and a rapid response is needed.
This trial proposes to study the addition of Durvalumab to chemotherapy in first line
treatment for frail patients with recurrent/metastatic SCCHN.
Prior to this evaluation, a run-in tolerance study in a limited number of patients to ensure
that the experimental treatment combination is safe.
Inclusion Criteria:
1. Age ≥ 18 years at the time of study entry;
2. Histological or cytological confirmation of the diagnosis of Squamous Cell Carcinoma
of the Head and Neck;
3. Primary tumor located in one of the following : oral cavity, larynx, oropharynx or
hypopharynx (NB: sinuses and nasopharynx locations are not allowed; isolated cervical
lymphnodes with unknown primary site may be discussed with the coordinating
investigator on a case by case basis)
4. Archival tumor sample available at the time of inclusion with sufficient material to
achieve the translational research program. Archival material must have been collected
3 months before inclusion at the latest, unless a new tumor sample must be collected.
5. Disease must be in metastatic (Stage IVc) or recurrent setting;
6. Documented progression of measurable disease as per the RECIST (NB: in case of a
single metastatic lesion, the tumor size must be > 20mm to allow tumor biopsy)
7. Patients must fulfil at least one of the following frailty criteria:
- Age > 70 years
- Creatinine clearance (CrCl) : 40 < CrCl < 60ml/min
- Any severe comorbidity rendering the patient ineligible to standard chemotherapy,
as per investigator's judgment.
8. Eastern Cooperative Oncology Group performance status of 0, 1 or 2
9. Must have a life expectancy of at least 12 weeks
10. Body weight > 30Kg;
11. Adequate organ and marrow function as defined below:
- Hemoglobin ≥ 9.0 g/dl
- Absolute Neutrophils Count (ANC) ≥ 1.0 x 109/L
- Platelet count ≥ 100 x 109/L
- Creatinine clearance ≥ 40 ml/min using the following appropriate formulae:
- Cockroft-Gault formula for female : 0.85 x weight (Kg) x (140-age) / 72 x
serum creatinine (mg/dL)
- Cockroft-Gault formula for male : weight (Kg) x (140-age) / 72 x serum
creatinine (mg/dL)
- MDRD for patients older than 65 years: 186.3 x (serum creatinine (µmol/L /
88.4) -1.154 x Age -0.203 x (0.742 if female) x (1.212 if black patient
[African origin]).
- AST/ALT ≤2.5 x institutional upper limit of normal unless liver metastases are
present, in which case it must be ≤5 x ULN
- Serum total bilirubin ≤ 1.5 x ULN (in the absence of Gilbert's syndrome)
- Coagulation panel : INR or PT ≤ 1.5 x ULN
12. Evidence of post-menopausal status or negative urinary or serum pregnancy test for
female pre-menopausal patients. Women will be considered post-menopausal if they have
been amenorrheic for 12 months without an alternative medical cause. The following
age-specific requirements apply:
- Women <50 years of age would be considered post-menopausal if they have been
amenorrheic for 12 months or more following cessation of exogenous hormonal
treatments and if they have luteinizing hormone and follicle-stimulating hormone
levels in the post-menopausal range for the institution or underwent surgical
sterilization (bilateral oophorectomy or hysterectomy).
- Women ≥50 years of age would be considered post-menopausal if they have been
amenorrheic for 12 months or more following cessation of all exogenous hormonal
treatments, had radiation-induced menopause with last menses >1 year ago, had
chemotherapy-induced menopause with last menses >1 year ago, or underwent
surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or
hysterectomy).
13. Patient using a highly effective contraception as defined in appendix 9. Prior to
dispensing study drugs, the investigator must confirm and document the patient's (and
his/her partner) use of highly effective contraceptive methods, dates of negative
pregnancy tests, and confirm the patient's understanding of the teratogenic potential
of study drugs.
14. Patient is willing and able to comply with the protocol for the duration of the study
including undergoing treatment and scheduled visits and examinations including follow
up.
15. Covered by a medical insurance.
16. Signed and dated informed consent document indicating that the patient has been
informed of all the pertinent aspects of the trial prior to enrolment
Exclusion Criteria:
1. History of another primary malignancy except for - Malignancy treated with curative
intent and with no known active disease ≥5 years before the first dose of IP and of
low potential risk for recurrence
- Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
of disease
- Adequately treated carcinoma in situ without evidence of disease
2. Prior anticancer therapy in metastatic or recurrent setting In case patient received
neoadjuvant or adjuvant anti-cancer treatment, it must have been completed for at
least 6 months prior to study drugs initiation and patient must have no unresolved
toxicity NCI CTCAE Grade ≥2 with the exception of alopecia, vitiligo and laboratory
values defined as inclusion criteria.
Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis after
consultation with the coordinating investigator.
Patients with irreversible toxicity not reasonably expected to be exacerbated by
treatment with durvalumab may be included only after consultation with the
coordinating investigator.
3. Any previous treatment with a PD1 or PD-L1 inhibitor, including durvalumab.
4. Patient whom tumor lesion is hemorrhagic or at risk of bleeding
5. Patient whom disease progressed within 6 months after the start date of the previous
chemotherapy (faster progressors)
6. Symptomatic or active leptomeningial or parenchymal brain metastases. Patients whose
brain metastases have been treated may participate provided they show radiographic
stability (defined as 2 brain images, both of which are obtained after treatment ot
the brain metastases; these Imaging scans should both be obtained at least 4 weeks
apart and show no evidence of intracranial progression). In addition, any neurologic
symptoms that developed either as a result of the brain metastases or their treatment
must have resolved or be stable either, without the use of steroids, or are stable on
a steroid dose of <=10mg/day of prednisone or its equivalent and anticonvulsant for at
least 14 days prior to the start of treatment.
with previously treated brain metastases (either by surgery, radiotherapy or
radiosurgery) may be enrolled if stable, off steroids, on imaging and clinically, for
at least 4 weeks.
7. Active or prior/history of disease/medical condition listed below:
- Documented autoimmune or inflammatory disease (including inflammatory bowel
disease [e.g., Crohn's disease, ulcerative colitis], diverticulitis, systemic
lupus erythematosus, sarcoidosis syndrome or Wegener syndrome, granulomatosis
with polyangitis, Grave's disease, rheumatoid arthritis, hypophysitis, uveitis,
etc) within the past 2 years except for autoimmune hypothyroidism on a stable
dose of thyroid supplementation and patients with type 1 diabetes mellitus on a
stable dose of insulin.
Note: Subjects with alopecia, vitiligo, Grave's disease, or psoriasis not requiring
systemic treatment (within the past 2 years) or chronic skin condition that does not
require systemic therapy, are not excluded, as well as patients without active disease in
the last 5 years (after consultation with the study physician) and patients with celiac
disease controlled by diet alone.
- Mean QT interval corrected for heart rate (QTc) ≥470 ms using Fredericia's Correction.
- Clinically significant cardiac disease or congestive heart failure > New York Heart
Association (NYHA) class 2. Patients must not have unstable angina (anginal symptoms
at rest) or new-onset angina within the last 3 months or myocardial infarction within
the past 6 months.
- History of primary immunodeficiency
- Allogeneic organ transplantation
- Documented hypersensitivity to the active substance or excipient of the study drugs
- Any uncontrolled intercurrent illness including, but not limited to:
o Ongoing or active infection, including tuberculosis (clinical evaluation that
includes clinical history, physical examination and radiographic findings, and
tuberculosis testing in line with local practice), hepatitis B (known positive HBV
surface antigen (HBsAg) result), hepatitis C, or human immunodeficiency virus
(positive HIV 1/2 antibodies). Patients with a past or resolved HBV infection (defined
as the presence of hepatitis B core antibody [anti-HBc] and absence of HBsAg) are
eligible. Patients positive for hepatitis C (HCV) antibody are eligible only if
polymerase chain reaction is negative for HCV RNA.
o Active peptic ulcer disease or gastritis,
- Active bleeding diatheses including any subject known to have evidence of acute,
- Serious chronic gastrointestinal conditions associated with diarrhea
- Any psychiatric illness/social situations that would limit compliance with study
requirements or compromise the ability of the subject to give written informed consent
8. Current or prior use, or need for the following concomitant
medications/interventions not permitted during the study treatment period :
- Any concurrent chemotherapy or radiotherapy treatment to more than 30% of the bone
marrow or with a wide field of radiation within 4 weeks of the first dose of study
drug (except palliative radiotherapy on a non-target lesion after discussion with the
coordinating investigator), immunotherapy, biologic or hormonal therapy for cancer
treatment, other than any stated in the protocol (Note: concurrent use of hormonal
therapy for non-cancer-related conditions (e.g. hormone replacement therapy) is
acceptable)).
- Current or prior use of immunosuppressive medication within 14 days before the first
dose of durvalumab including, but not limited to systemic corticosteroids at doses
exceeding 10 mg/day of prednisone or equivalent, methotrexate, azathioprine, and TNF-α
blockers. Use of immunosuppressive medications for the management of investigational
product-related AEs or in subjects with contrast allergies is acceptable.
- Receipt of live attenuated vaccine within 30 days prior to the first dose of IP (Note:
Patients, if enrolled, should not receive live vaccine whilst receiving IP and up to
30 days after the last dose of IP).
- Strong inhibitors and inducers of CYP3A4
- Major surgical procedure (as defined by the Investigator) within 28 days prior to
the first dose of IP. Note: Local surgery of isolated lesions for palliative
intent is acceptable.
8. Participation in another clinical study with an investigational product during
the last 28 days prior to first study drug administration
9. Concurrent enrolment in another clinical study, unless it is an observational
(non-interventional) clinical study or during the follow-up period of an
interventional study
10. Pregnant or breastfeeding women (Women of childbearing potential are required
to have a negative serum pregnancy test within 72 hours prior to study treatment
start. A positive urine test must be confirmed by a serum pregnancy test).
